▍經歷
- 臺灣大學生物科技食品營養學士學程助理教授
- 臺大醫院醫學研究部主治醫師
- 臺灣大學醫學院內科兼任助理教授
- 臺大醫院北護分院肝膽腸胃科主治醫師
- 臺大醫院肝膽腸胃科研修醫師
- 臺大醫院內科總醫師
▍主要專長
▍研究方向
- Human Microbiome
- Nutrimicrobiomics
- Next generation probiotics
▍近五年論文發表
- Wei-Kai Wu*, Yi-Ling Lo, Jian-Ying Chiu, Chia-Lang Hsu, I-Hsuan Lo, Suraphan Panyod, Yu-Chieh Liao, Tina H T Chiu, Yu-Tang Yang, Han-Chun Kuo, Hsin-Bai Zou, Yi-Hsun Chen, Hsiao-Li Chuang, Jeffrey J Y Yen, Jin-Town Wang, Han-Mo Chiu, Cheng-Chih Hsu, Ching-Hua Kuo, Lee-Yan Sheen, Hsien-Li Kao, Ming-Shiang Wu*. Gut microbes with the gbu genes determine TMAO production from L-carnitine intake and serve as a biomarker for precision nutrition. Gut Microbes. 2025; 17(1):2446374. DOI: 10.1080/19490976.2024.2446374.
- Ting-Yun Lin, Wei-Kai Wu* & Szu-Chun Hung*. High interindividual variability of indoxyl sulfate production identified by an oral tryptophan challenge test. npj Biofilms and Microbiomes. 2025; 11:15. DOI: 10.1038/s41522-025-00651-8
- Suraphan Panyod, Wei-Kai Wu, Ya-Chi Hsieh, Yea-Jing Tseng, Sin-Yi Peng, Rou-An Chen, Huai-Syuan Huang, Yi-Hsun Chen, Ting-Chin David Shen, Chi-Tang Ho, Chun-Jen Liu, Hsiao-Li Chuang, Chi-Chang Huang, Ming-Shiang Wu*, Lee-Yan Sheen*. Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbi-ota-LPS-TLR4 pathway in mice. Nutrition & Diabetes. 2024; 14(1):65. DOI: 10.1038/s41387-024-00306-1
- Suraphan Panyod, Wei-Kai Wu, Chih-Ting Chang, Naohisa Wada, Han-Chen Ho, Yi-Ling Lo, Sing-Ping Tsai, Rou-An Chen, Huai-Syuan Huang, Po-Yu Liu, Yi-Hsun Chen, Hsiao-Li Chuang, Ting-Chin David Shen, Sen-Lin Tang, Chi-Tang Ho, Ming-Shiang Wu*, Lee-Yan Sheen*. Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice. Communications Biology. 2024; 7(1):749. DOI: 10.1038/s42003-024-06224-3
- Suraphan Panyod, Wei-Kai Wu, Meng-Yun Hu, Huai-Syuan Huang, Rou-An Chen, Yi-Hsun Chen, Ting-Chin David Shen, Chi-Tang Ho, Chun-Jen Liu, Hsiao-Li Chuang, Chi-Chang Huang, Ming-Shiang Wu*, Lee-Yan Sheen*. Healthy diet intervention reverses the progression of NASH through gut microbiota modulation. Microbiology Spectrum. 2024; 12(1):e0186823. DOI: 10.1128/spectrum.01868-23
- Suraphan Panyod, Wei-Kai Wu, Sin-Yi Peng, Yea-Jing Tseng, Ya-Chi Hsieh, Rou-An Chen, Huai-Syuan Huang, Yi-Hsun Chen, Hsiao-Li Chuang, Cheng-Chih Hsu, Ting-Chin David Shen, Kai-Chien Yang, Chi-Tang Ho, Ming-Shiang Wu*, Lee-Yan Sheen*. Ginger essential oil and citral ameliorates atherosclerosis in ApoE-/- mice by modulating trimethylamine-N-oxide and gut microbiota. npj Science of Food. 2023; 20;7(1):19. DOI: 10.1038/s41538-023-00196-0
- Der-Sheng Han, Wei-Kai Wu, Po-Yu Liu, Yu-Tang Yang, Hsiu-Ching Hsu, Ching-Hua Kuo, Ming-Shiang Wu*, Tyng-Guey Wang*. Differences in the gut microbiome and reduced fecal butyrate in elders with low skeletal muscle mass. Clinical Nutrition. 2022; 41(7):1491-1500. DOI: 10.1016/j.clnu.2022.05.008
- Rou-An Chen, Wei-Kai Wu, Suraphan Panyod, Po-Yu Liu, Hsiao-Li Chuang, Yi-Hsun Chen, Qiang Lyu, Hsiu-Ching Hsu, Tzu-Lung Lin, Ting-Chin David Shen, Yu-Tang Yang, Hsin-Bai Zou, Huai-Syuan Huang, Yu-En Lin, Chieh-Chang Chen, Chi-Tang Ho, Hsin-Chih Lai, Ming-Shiang Wu, Cheng-Chih Hsu*, Lee-Yan Sheen*. Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition. mSystems. 2022; 7(3):e0017222. DOI: 10.1128/msystems.00172-22
- Suraphan Panyod, Wei-Kai Wu, Pei-Chen Chen, Kent-Vui Chong, Yu-Tang Yang, Hsiao-Li Chuang, Chieh-Chang Chen , Rou-An Chen, Po-Yu Liu, Ching-Hu Chung, Huai-Syuan Huang, Angela Yu-Chen Lin, Ting-Chin David Shen, Kai-Chien Yang, Tur-Fu Huang, Cheng-Chih Hsu, Chi-Tang Ho, Hsien-Li Kao, Alexander N Orekhov, Ming-Shiang Wu*, Lee-Yan Sheen*. Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation. npj Biofilms and Microbiomes. 2022; 27;8(1):4. DOI: 10.1038/s41522-022-00266-3
- Hsin-Yu Liao, Chin-Yi Wang, Ching-Hua Lee, Hsien-Li Kao, Wei-Kai Wu*, Ching-Hua Kuo*. Development of an Efficient and Sensitive Chemical Derivatization-Based LC-MS/MS Method for Quantifying Gut Microbiota-Derived Metabolites in Human Plasma and Its Application in Studying Cardiovascular Disease. Journal of Proteome Research. 2021; 2;20(7):3508-3518. DOI: 10.1021/acs.jproteome.1c00147
- Wei-Kai Wu, Ekaterina A Ivanova*, Alexander N Orekhov*. Gut microbiome: A possible common therapeutic target for treatment of atherosclerosis and cancer. Seminars in Cancer Biology. 2021; 70:85-97. DOI: 10.1016/j.semcancer.2020.06.017
- Wei-Kai Wu, Yi-Hsun Chen, Po-Chu Lee, Po-Jen Yang, Chin-Chen Chang, Kao-Lang Liu, Cheng-Chih Hsu, Chi-Chang Huang, Hsiao-Li Chuang, Lee-Yan Sheen, Chun-Jen Liu, Ming-Shiang Wu*. Mining Gut Microbiota from Bariatric Surgery for MAFLD. Frontiers in Endocrinology. 2021; 12:612946. DOI: 10.3389/fendo.2021.612946
- Chih-Fan Yeh, Ying-Hsien Chen, Sheng-Fu Liu, Hsien-Li Kao, Ming-Shiang Wu, Kai-Chien Yang*, Wei-Kai Wu*. Mutual Interplay of Host Immune System and Gut Microbiota in the Immunopathology of Atherosclerosis. International Journal of Molecular Sciences. 2020; 21(22):8729. DOI: 10.3390/ijms21228729
- Wei-Kai Wu, Suraphan Panyod, Po-Yu Liu, Chieh-Chang Chen, Hsien-Li Kao, Hsiao-Li Chuang, Ying-Hsien Chen, Hsin-Bai Zou, Han-Chun Kuo, Ching-Hua Kuo, Ben-Yang Liao, Tina H T Chiu, Ching-Hu Chung, Angela Yu-Chen Lin, Yi-Chia Lee, Sen-Lin Tang, Jin-Town Wang, Yu-Wei Wu, Cheng-Chih Hsu, Lee-Yan Sheen, Alexander N Orekhov, Ming-Shiang Wu*. Characterization of TMAO productivity from carnitine challenge facilitates personalized nutrition and microbiome signatures discovery. Microbiome. 2020; 8(1):162. DOI: 10.1186/s40168-020-00912-y
- Wei-Kai Wu, Jyh-Ming Liou, Cheng-Chih Hsu, Yung-Hsiang Lin, Ming-Shiang Wu*. Pandemic preparedness in Taiwan. Nature Biotechnology. 2020; 38(8):932-933. DOI: 10.1038/s41587-020-0630-0
- Chieh-Chang Chen, Wei-Kai Wu, Chih-Min Chang, Suraphan Panyod, Tzu-Pin Lu, Jyh-Ming Liou, Yu-Jen Fang, Eric Y Chuang, Ming-Shiang Wu*. Comparison of DNA stabilizers and storage conditions on preserving fecal microbiota profiles. Journal of the Formosan Medical Association. 2020; 119(12):1791-1798. DOI: 10.1016/j.jfma.2020.01.013
- Wei-Kai Wu, Cheng-Chih Hsu, Lee-Yan Sheen, Ming-Shiang Wu*. Measurement of Gut Microbial Metabolites in Cardiometabolic Health and Translational Research. Rapid Communications in Mass Spectrometry. 2020; 34 Suppl 1:e8537. DOI: 10.1002/rcm.8537
- Wei-Kai Wu, Chieh-Chang Chen, Po-Yu Liu, Suraphan Panyod, Ben-Yang Liao, Pei-Chen Chen, Hsien-Li Kao, Han-Chun Kuo, Ching-Hua Kuo, Tina H T Chiu, Rou-An Chen, Hsiao-Li Chuang, Yen-Te Huang, Hsin-Bai Zou, Cheng-Chih Hsu, Ting-Yan Chang, Chin-Lon Lin, Chi-Tang Ho, Hon-Tsen Yu, Lee-Yan Sheen*, Ming-Shiang Wu*. Identification of TMAO-producer phenotype and host-diet-gut dysbiosis by carnitine challenge test in human and germ-free mice. Gut. 2019; 68(8):1439-1449. DOI: 10.1136/gutjnl-2018-317155
- Ya-Lin Hsu, Chieh-Chang Chen, Ya-Ting Lin, Wei-Kai Wu, Lin-Chau Chang, Chang-Hao Lai, Ming-Shiang Wu*, Ching-Hua Kuo*. Evaluation and optimization of sample handling methods for quantification of short-chain fatty acids in human fecal samples by GC-MS. Journal of Proteome Research. 2019; 18(5), 1948-1957. DOI: 10.1021/acs.jproteome.8b00536
- Wei-Kai Wu, Chieh-Chang Chenc, Suraphan Panyod, Rou-An Chen, Ming-Shiang Wu, Lee-Yan Sheen*, Shan-Chwen Chang*. Optimization of Fecal Sample Processing for Microbiome Study — The Journey from Bathroom to Bench. Journal of the Formosan Medical Association. 2019;118(2):545-555. DOI: 10.1016/j.jfma.2018.02.005
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