▍聯繫資訊

• 辦公室：第六共研
• 電話：院內分機 263250
• Email：shuyih@ntuh.gov.tw
• 實驗室網站：（建置中）

▍學歷

• Ph.D., Genes and Development, University of Texas Southwestern Medical Center
• M.S., Zoology, University of Hawaii at Manoa
• B.S., Zoology, National Taiwan University

▍經歷

• Postdoctoral Researcher, Dr. Beth Levine's Lab, UT Southwestern
• Postdoctoral Researcher, Dr. Rueyling Lin's Lab, UT Southwestern

▍主要專長

• 細胞學
• 分子生物學
• 線蟲遺傳學
• 發育生物學

▍研究方向

• 細胞鞘脂(sphingolipids)平衡通過影響細胞膜及胞器的膜組成，對於胞內體運輸、氧化壓力、自噬活性及外泌體生成所造成的影響及其分子機制。

▍近五年論文發表

• Fei-Yang Tzou, Thorsten Hornemann, Jui-Yu Yeh, Shu-Yi Huang (2023, May). The pathophysiological role of dihydroceramide desaturase in the nervous system. Progress in Lipid Research, 91:101236, 2023. DOI: http://doi.org/10.1016/j.plipres.2023.101236.
• Chen-Yi Wu, Jhih-Gang Jhang, Wan-Syuan Lin, Pei-Huan Chuang, Chih-Wei Lin, Li-An Chu, Ann-Shyn Chiang, Han-Chen Ho, Chih-Chiang Chan, Shu-Yi Huang (2021, Nov). Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production. iScience, 2021,103437. DOI: https://doi.org/10.1016/j.isci.2021.103437.
• Yu-Chien Hung, Kuan-Lin Huang, Po-Lin Chen, Jeng-Lin Li, Serena Huei-An Lu, Jui-Chih Chang, Han-Yi Lin, Wen-Chun Lo, Shu-Yi Huang, Tai-Ting Lee, Tai-Yi Lin, Yuzuru Imai, Nobutaka Hattori, Chin-San Liu, Su-Yi Tsai, Chun- Hong Chen, Chin-Hsien Lin, Chih-Chiang Chan (2021, Sep). UQCRC1 engages cytochrome c for neuronal apoptotic cell death. Cell Reports, 36(12), 109729. DOI: https://doi.org/10.1016/j.celrep.2021.109729.
• Fei-Yang Tzou, Tsu-Yi Su, Wan-Syuan Lin, Han-Chun Kuo, Yu-Lian Yu, Yu-Han Yeh, Chung-Chih Liu, Ching-Hua Kuo, Shu-Yi Huang, Chih-Chiang Chan. Dihydroceramide desaturase regulates the compartmentalization of Rac1 for neuronal oxidative stress. Cell Reports, 35(2), 108972, 2021. DOI: 10.1016/j.celrep.2021.108972. 
• Wen-Yu Lien, Yu-Ting Chen, Yi-Jhan Li, Jie-Kai Wu, Kuan-Lin Huang, Jian-Rong Lin, Shih-Ching Lin, Chia-Chun Hou, Horng-Dar Wang, Chia-Lin Wu, Shu-Yi Huang, Chih-Chiang Chan (2020, Jul). Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27. Aging Cell, 19(8):e13179, 2020. DOI: 10.1111/acel.13179.
• Wei Hung Jung, Chung Chih Liu, Yu‐Lian Yu, Yu‐Chin Chang, Wen‐Yu Lien, Hsi‐Chun Chao, Shu‐Yi Huang, Ching‐Hua Kuo, Han‐Chen Ho, and Chih‐Chiang Chan (2017, Jul). Lipophagy prevents activity‐dependent neurodegeneration due to dihydroceramide accumulation in vivo. EMBO reports, 18(7):1150-1165, 2017. DOI: 10.15252/embr.201643480.