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許家郎副研究員

▍聯繫資訊
  • 辦公室:第二共研
  • 電話:院內分機 265989
  • Email:chialanghsu@ntuh.gov.tw
  • 實驗室網站:點選另開視窗

 

▍學歷
  • 國立陽明大學生物醫學資訊研究所  博士
  • 國立陽明大學醫學放射技術學系  學士

 

許家郎助理研究員
▍經歷
  • 國立陽明大學系統與合成生物學研究中心  博士後研究員
  • 國立臺灣大學生命科學系  博士後研究員
  • 國立臺灣大學醫學院腫瘤醫學研究所  兼任助理教授
  • 國立臺灣大學醫學院基因體暨蛋白體醫學研究所  兼任助理教授
 
▍主要專長
  • 生物資訊學
  • 系統生物學
  • 網路生物學
  • 次世代定序

 

▍研究方向
  • Development of NGS-based genetic test in clinical application
  • Biomarker discovery in cancer immunotherapy
  • Interactions between immune and tumor cells in tumor microenvironment

 

▍近五年論文發表
  • Ou DL, Tseng SJ, Kempson IM, Hsu CL, Yang PC, Liao ZX. Enhanced targeting and immune activation of tumor microenvironment by nanomodified anti-PD1 in liver cancer. Adv Therapeutics. 2021. 2021:2100048. DOI: 10.1002/adtp.202100048.
  • Wang MH*, Hsu CL*, Wu CH, Chiou LL, Tsai YT, Lee HS, Lin SP. Timing does matter: Nerve-mediated HDAC1 paces the temporal expression of morphogenic genes during axolotl limb regeneration. Front Cell Dev Biol. 2021. DOI: 10.3389/fcell.2021.641987. (共同第一作者)
  • Hsu CL*, Ou DL*, Bai LY, Chen CW, Lin L, Huang SF, Cheng AL, Cheng YM, Hsu C. Exploring markers of exhausted CD8 T cells to predict response to immune checkpoint inhibitor therapy for hepatocellular carcinoma. Liver Cancer. 2021; 10:346-359. DOI: 10.1159/000515305. (共同第一作者)
  • Ou DL*, Chen CW*, Hsu CL*, Chung CH, Feng ZR, Lee BS, Cheng AL, Yang MH, Hsu C. Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages. J Immunother Cancer. 2021. 9(3):e001657. DOI: 10.1136/jitc-2020-001657 (共同第一作者)
  • Chiang CS, Fu SJ, Hsu CL, Jeng CJ, Tang CY, Huang YS, Tang SC. Neuronal exosomes secreted under oxygen-glucose deprivation/reperfusion presenting differentially expressed miRNAs and affecting neuronal survival and neurite outgrowth. Neuromolecular Med. 2021. DOI: 10.1007/s12017-020-08641-z.
  • Wang YH, Lin CC, Hsu CL, Hung SY, Yao CY, Lee SH, Tsai CH, Hou HA, Chou WC, Tien HF. Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125. Ann Hematol. 2021. 100(2):487-498.  DOI: 10.1007/s00277-020-04358-y.
  • Hung SY, Lin CC, Hsu CL, Yao CY, Wang YH, Tsai CH, Hou HA, Chou WC, Tien HF. The expression levels of long non‐coding RNA KIAA0125 are associated with distinct clinical and biological features in myelodysplastic syndromes. Br J Haematol. 2021. 192(3):589-598. DOI: 10.1111/bjh.17231.
  • Chung KP, Huang YL, Chen YJ, Juan YH, Hsu CL, Nakahira K, Huang YT, Lin MW, Wu SG, Shih JY, Chang YL, Yu CJ. Multi-kinase framework regulates activation of dynamin-related protein 1 to promote proliferation and invasion of lung adenocarcinoma. Mol Oncol. 2021. 15(2):560-578. DOI: 10.1002/1878-0261.12843.
  • Chang YW, Hsu CL, Tang CW, Chen XJ, Hang HC, Juan HF. Multiomics reveals ectopic ATP synthase blockade induces cancer cell death via a lncRNA-mediated phospho-signaling network. 2020. Mol Cell Proteomics. 19(11):1805-1825. DOI: 10.1074/mcp.RA120.002219.
  • Cheung CHY, Hsu CL, Lin TY, Chen WT, Wang YC, Huang HC, Juan HF. ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer. 2020. J Biomed Sci. 27(1):75. DOI: 10.1186/s12929-020-00668-5.
  • Wang WH, Hsu CL, Huang HC, Juan HF. Quantitative phosphoproteomics reveals cell alignment and mitochondrial length change under cyclic stretching in lung cells. 2020. Int J Mol Sci. 21(11):E4074. DOI: 10.3390/ijms21114074
  • Wang HY, Liu YN, Wu SG, Hsu CL, Chang TH, Tsai MF, Lin YT, Shih JY. MiR-200c-3p suppression is associated with development of acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR mutant non-small cell lung cancer via a mediating epithelial-to-mesenchymal transition (EMT) process. Cancer Biomark. 2020. 28(3):351-363. DOI: 10.3233/CBM-191119.
  • Yin CF, Kao SC, Hsu CL, Chang YW, Cheung CHY, Huang HC, Juan HF. Phosphoproteome analysis reveals dynamic heat shock protein 27 phosphorylation in tanshinone IIA-induced cell death.  J Proteome Res. 2020. 19(4):1620-1634. DOI: 10.1021/acs.jproteome.9b00836.
  • Ho TC, Wang EY, Yeh KH, Jeng YM, Horng JH, Wu LL, Chen YT, Huang HC, Hsu CL, Chen PJ, Yeh SH, Chen DS. Complement C1q mediates the expansion of periportal hepatic progenitor cells in senescence-associated inflammatory liver. Proc Natl Acad Sci U S A. 2020. 117(12):6717-6725. DOI: 10.1073/pnas.1918028117.
  • Shen YC, Hsu CL, Jeng YM, Ho MC, Ho CM, Yeh CP, Yeh CY, Hsu MC, Hu RH, Cheng AL. Reliability of a single-region tumor sample for evaluating the immune tumor microenvironment of hepatocellular carcinoma tumors. J Hepatol. 2020. 72:489-497. DOI: 10.1016/j.jhep.2019.09.032.
  • Wang YH, Lin CC, Yao CY, Hsu CL, Hou HA, Tsai HC, Chou WC, Tien HF. A four-gene leukemic stem cell score can independently predict the prognosis of myelodysplastic syndrome patients. Blood Advances. 2020. 4(4):644-654. DOI: 10.1182/bloodadvances.2019001185
  • Lee PC, Chen ST, Kuo TC, Lin TC, Lin MC, Huang J, Hung JS, Hsu CL, Juan HF, Lee PH, Huang MC. C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer. Oncogene. 2020. 39(13):2724-2740. DOI: 10.1038/s41388-020-1178-7.
  • Cheung CHY, Hsu CL, Tsuei CY, Kuo TT, Huang CT, Hsu WM, Chung YH, Wu HY, Hsu CC, Huang HC, Juan HF. Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy. Cell Death Dis. 2019. 10(11):786. DOI: 10.1038/s41419-019-2033-z.
  • Chang HC*, Huang HC*, Juan HF*, Hsu CL*. Investigating the role of super-enhancer RNAs underlying embryonic stem cell differentiation. BMC Genomics. 2019. 20(Suppl 10):896. DOI: 10.1186/s12864-019-6293-x (通訊作者).
  • Hsieh CH, Cheung CHY, Liu YL, Hou CL, Hsu CL, Huang CT, Yang TS, Chen SF, Chen CN, Hsu WM, Huang HC, Juan HF. Quantitative proteomics of Th-MYCN transgenic mice reveals aurora kinase inhibitor altered metabolic pathways and enhanced ACADM to suppress neuroblastoma progression. J Proteome Res. 2019. 18(11):3850-3866.  DOI: 10.1021/acs.jproteome.9b00245
  • Hsu YC, Chen TC, Lin CC, Yuan CT, Hsu CL, Hou HA, Kao CJ, Chuang PH, Chen YR, Chou WC, Tien HF.  Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials. Blood Advances. 2019; 3(15):2355-2367. DOI: 10.1182/bloodadvances.2019000391.
  • Chung KP, Hsu CL, Fan LC, Huang Z, Bhatia D, Chen YC, Hisata S, Cho SJ, Nakahira K, Imamura M, Choi ME, Yu CJ, Cloonan SM, Choi MK. Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis. Nat Communication. 2019; 10:3390. DOI: 10.1038/s41467-019-11327-1.
  • Wu SG, Chang TH, Tsai MF, Liu YN, Hsu CL, Chang YL, Yu CJ, Shih JY. IGFBP7 drives resistance to epidermal growth factor receptor tyrosine kinase inhibition in lung cancer. Cancers (Basel). 2019; 11(1):36 ; DOI: 10.3390/cancers11010036.
  • Ou DL, Lin YY, Hsu CL, Lin YY, Chen CW, Yu JS, Miaw SC, Hsu PN, Cheng AL, Hsu C. Development of a PD-L1-expressing orthotopic liver cancer model: implications for immunotherapy for hepatocellular carcinoma . Liver Cancer. 2019; 8(3):155-171. DOI: 10.1159/000489318.
  • Yang TW, Sahu D, Chang YW, Hsu CL, Hsieh CH, Huang HC, Juan HF. RNA-binding proteomics reveals MATR3 interacting with lncRNA SNHG1 to enhance neuroblastoma progression. J Proteome Res. 2019; 18(1):406-416.; DOI: 10.1021/acs.jproteome.8b00693.
  • Cheung CHY, Hsu CL, Chen KP, Chong ST, Wu CH, Huang HC, Juan HF. MCM2-regulated functional networks in lung cancer by multi-dimensional proteomic approach. Sci Rep. 2017; 7:13302. DOI: 10.1038/s41598-017-13440-x.
  • Hsu CL, Wang JK, Lu PC, Huang HC, and Juan HF. DynaPho: a web platform for inferring the dynamics of time-series phosphoproteomics. Bioinformatics. 2017; 33:3664–3666. DOI: 10.1093/bioinformatics/btx443.
  • Hua KT, Liu YF, Hsu CL, Cheng TY, Yang CY, Chang JS, Lee WJ, Hsiao M, Juan HF, Chien MH, Yang SF. 3'UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma. Sci Rep. 2017; 7(1):4466. DOI: 10.1038/s41598-017-04732-3.
  • Lin TC, Chen ST, Huang MC, Huang J, Hsu CL, Juan HF, Lin HH, Chen CH. GALNT6 expression enhances aggressive phenotypes of ovarian cancer cells by regulating EGFR activity. Oncotarget. 2017;8(26):42588-42601. DOI: 10.18632/oncotarget.16585.
  • Lin MC, Lin JJ, Hsu CL, Juan HF, Lou PJ, and Huang MC. GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness. Oncogene. 2017;36(30):4243-4252. DOI: 10.1038/onc.2017.8.