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許家郎副研究員

▍聯繫資訊
  • 辦公室:第二共研
  • 電話:院內分機 265989
  • Email:chialanghsu@ntuh.gov.tw
  • 實驗室網站:點選另開視窗

 

▍學歷
  • 國立陽明大學生物醫學資訊研究所  博士
  • 國立陽明大學醫學放射技術學系  學士

 

許家郎博士
▍經歷
  • 國立臺灣大學醫學院腫瘤醫學研究所  兼任助理教授 (2019-)
  • 國立臺灣大學醫學院基因體暨蛋白體醫學研究所  兼任助理教授 (2020-)
  • 國立臺灣大學醫學院毒理學研究所 兼任助理教授 (2021-)
  • 國家高速網路與計算中心 兼任副研究員 (2022-)
  • 台灣演化與計算生物學會 秘書長 (2021-2024)
  • 國立臺灣大學生命科學系  博士後研究員 (2012-2017)
  • 國立陽明大學系統與合成生物學研究中心  博士後研究員 (2012-2012)
 
▍主要專長
  • 生物資訊學
  • 系統生物學
  • 網路生物學
  • 次世代定序

 

▍研究方向
  • Development of NGS-based genetic test in clinical application
  • Biomarker discovery in cancer immunotherapy
  • Interactions between immune and tumor cells in tumor microenvironment

 

▍近五年論文發表
  • Liao YH, Hsu CL, Leu CY, Lai SF, Huang YL, Hsieh MS, Chen TC, Chen CN, Wang CP, Yang TL, Tsai MH, Lin MC, Lou PJ. Radiation-induced sarcoma of head and neck: clinical characteristics and molecular signatures. Head & Neck. 2022. 10.1002/hed.27279
  • Yao CY, Lin CC, Wang YH, Hsu CL, Kao CJ, Hou HA, Chou WC, Tien HF. The clinical and biological characterization of acute myeloid leukemia patients with S100A4 overexpression. J Formos Med Assoc. 2022. doi: 10.1016/j.jfma.2022.11.003
  • Lee WH, Lin CC, Wang YH, Yao CY, Kuo YY, Tseng MH, Peng YL, Hsu CA, Sun HI, Chuang YK, Hsu CL, Tien FM, Tsai CH, Chou WC, Hou HA, Tien HF. Distinct genetic landscapes and their clinical implications in younger and older patients with myelodysplastic syndromes. Hematol Oncol. 2022. doi: 10.1002/hon.3109
  • Lin MC, Hsu CL, Lai SF, Huang YL, Hsieh MS, Chen TC, Chen CN, Wang CP, Yang TL, Ko JY, Tsai MH, Lou PJ. Spindle cell carcinoma of the head and neck: clinical characteristics and molecular signatures. Laryngoscope. 2022. doi: 10.1002/lary.30467
  • Chen KP, Hsu CL, Oyang YJ, Huang HC, Juan HF. BIC: a database for the transcriptional landscape of bacteria in cancer. Nucleic Acids Res. 2022. doi: 10.1093/nar/gkac891
  • Chen KH, Hsu CL, Su YL, Yuan CT, Lin LI, Tsai JH, Liang YH, Cheng AL, Yeh KH. Novel prognostic implications of complement activation in the tumour microenvironment for de novo metastatic BRAF V600E mutant colorectal cancer. Br J Cancer. 2022. doi: 10.1038/s41416-022-02010-2
  • Wu SY, Wu HT, Wang YC, Chang CJ, Shan YS, Wu SR, Chiu YC, Hsu CL, Juan HF, Lan KY, Chu CW, Lee YR, Lan SH, Liu HS. Secretory autophagy promotes RAB37-mediated insulin secretion under glucose stimulation both in vitro and in vivo. Autophagy. 2022. doi: 10.1080/15548627.2022.2123098
  • Chen TWW, Hsu CL, Hong RL, Lee JC, Chang K, Yu CW, Chen SC, Guo JC, Chen ML, Hsu MC, Kung TF, Cheng AL, Yen CC. A single-arm phase Ib/II study of lenvatinib plus eribulin in advanced liposarcoma and leiomyosarcoma. Clin Cancer Res. 2022. 28(23):5058-5065. doi: 10.1158/1078-0432.CCR-22-2092
  • Hsu CL, Yin CF, Chang YW, Fan YC, Lin SH, Wu YC, Huang HC, Juan HF. LncRNA SNHG1 regulates neuroblastoma cell fate via interactions with HDAC1/2. Cell Death Dis. 2022. 13(9):809. doi: 10.1038/s41419-022-05256-z
  • Jhuang YL, Yang CW, Tseng YF, Hsu CL, Li HY, Yuan RH, Jeng YM. SIN3-HDAC complex-associated factor, a chromatin remodelling gene located in the 12p amplicon, is a potential germ cell tumour-specific oncogene. J Pathol. 2022. 258(4):353-365. doi: 10.1002/path.6007 
  • Wang YH, Yao CY, Lin CC, Chen CL, Hsu CL, Tsai CH, Hou HA, Chou WC, Tien HF. Higher RUNX1 expression levels are associated with worse overall and leukaemia-free survival in myelodysplastic syndrome patients. eJHaem. 2022. 3:1209–1219. doi: 10.1002/jha2.547
  • Lin MJ, Lin YC, Chen NC, Luo AC, Lai SK, Hsu CL, Hsu JS, Chen CY, Yang WS, Chen PL. Profiling genes encoding the adaptive immune receptor repertoire with gAIRR suite. Front Immunol. 2022. 13:922513. doi: 10.3389/fimmu.2022.922513
  • Guo JC, Lin CC, Hsu CL, Huang TC, Kuo HY, Lin CY, Lien MY, Cheng AL, Hsu CH. Deleterious alterations of DNA damage response and repair genes and clinical benefit to Anti-PD-1 therapy in esophageal squamous cell cacinoma. Esophagus. 2022. 19(4):693-701. doi: 10.1007/s10388-022-00940-7
  • Guo JC*, Hsu CL*, Huang YL, Lin CC, Huang TC, Wu IC, Lin CY, Lien MY, Kuo HY, Cheng AL, Hsu CH. B cells in tumor microenvironment associated with the clinical benefit to programmed cell death protein-1 blockade therapy in patients with advanced esophageal squamous cell carcinoma. Front Oncology. 2022. 12:879398. doi: 10.3389/fonc.2022.879398
  • Chen IC, Awasthi D, Hsu CL, Song M, Chae CS, Dannenberg AJ, Cubillos-Ruiz JR. High fat diet-induced obesity alters dendritic cell homeostasis by enhancing mitochondrial fatty acid oxidation. J Immunol 2022. 209(1):69-76. doi: 10.4049/jimmunol.2100567.
  • Yuan RH*, Hsu CL*, Jhuang YL, Liu YR, Hsieh TH, Jeng YM. Tumor-matrix interaction induces phenotypic switching in liver cancer cells. Hepatol Int. 2022. 16(3):562-576. doi: 10.1007/s12072-022-10315-w.
  • Li A, Chen JY, Hsu CL, Oyang YJ, Huang HC, Juan HF. A single-cell network-based drug repositioning strategy for post-COVID-19 pulmonary fibrosis. Pharmaceutics. 2022. 14:971. doi: 10.3390/pharmaceutics14050971
  • Chyuan IT, Chu CL, Hsu CL, Pan MH, Liao HJ, Wu CS, Hsu PN. T Cell-specific deletion of TRAIL receptor reveals its critical role for regulating Ppathologic T cell activation and disease induction in experimental autoimmune encephalomyelitis. J Immunol. 2022. 208(7):1534-1544. doi: 10.4049/jimmunol.2100788
  • Wang YH, Lin CC, Yao CY, Hsu CL, Tsai CH, Hou HA, Chou WC, Tien HF. Immune signatures of bone marrow cells can independently predict prognosis in patients with myelodysplastic syndrome. Br J Haematol. 2022. 196(1):156-168. doi: 10.1111/bjh.17837.
  • Yu WH, Hsu CL, Lin CC, Oyang YJ, Juan HF, Huang HC. Stratification of lncRNA modulation networks in breast cancer. BMC Med Genomics. 2021. 14(Suppl 3):300. doi: 10.1186/s12920-022-01236-6.
  • Wu YC, Chen CI, Chen PY, Kuo CH, Hung YH, Peng KY, Wu VC, Tasi-Wu JJ#, Hus CL#. GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism. BMC Bioinformatics. 2021. 22:613. doi: 10.1186/s12859-022-04561-w
  • Li A, Yu WH, Hsu CL, Huang HC, Juan HF. Modular signature of long non-coding RNA association networks as a prognostic biomarker in lung cancer. BMC Med Genomics. 2021. 14(Suppl 3):290. doi: 10.1186/s12920-021-01137-0.
  • Wang HY, Hou HA, Lin CC, Kuo YY, Yao CY, Hsu CL, Tseng MH, Tsai CH, Peng YL, Kao CJ, Chou WC, Tien HF. A CIBERSORTx-based immune-cell scoring system could independently predict prognosis of myelodysplastic syndrome patients. Blood Adv. 2021. 5(22):4535-4548. doi: 10.1182/bloodadvances.2021005141.
  • Chen HY, Hsu CL, Lin HY, Lin YF, Tsai SF, Ho YJ, Li YR, Tsai JW, Teng SC, Lin CH. Clinical and functional characterization of a novel STUB1 frameshift mutation in autosomal dominant spinocerebellar ataxia type 48 (SCA48). J Biomed Sci. 2021. 28(1):65. doi: 10.1186/s12929-021-00763-1.
  • Chang KH, Huang CY, Ou-Yang CH, Ho CH, Lin HY, Hsu CL, Chen YT, Chou YC, Chen YJ, Chen Y, Lin JL, Wang JK, Lin PW, Lin YR, Lin MH, Tseng CK, Lin CH. In vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation. Stem Cell Res Ther. 2021. 12(1):508. doi: 10.1186/s13287-021-02585-2.
  • Ou DL, Tseng SJ, Kempson IM, Hsu CL, Yang PC, Liao ZX. Enhanced targeting and immune activation of tumor microenvironment by nanomodified anti-PD1 in liver cancer. Adv Therapeutics. 2021. 2021:2100048. doi: 10.1002/adtp.202100048
  • Wang MH*, Hsu CL*, Wu CH, Chiou LL, Tsai YT, Lee HS, Lin SP. Timing does matter: Nerve-mediated HDAC1 paces the temporal expression of morphogenic genes during axolotl limb regeneration. Front Cell Dev Biol. 2021. 9:641987. doi: 10.3389/fcell.2021.641987
  • Hsu CL*, Ou DL*, Bai LY, Chen CW, Lin L, Huang SF, Cheng AL, Cheng YM, Hsu C. Exploring markers of exhausted CD8 T cells to predict response to immune checkpoint inhibitor therapy for hepatocellular carcinoma. Liver Cancer. 2021. 10(4):346-359. doi: 10.1159/000515305
  • Ou DL*, Chen CW*, Hsu CL*, Chung CH, Feng ZR, Lee BS, Cheng AL, Yang MH, Hsu C. Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages. J Immunother Cancer. 2021. 9(3):e001657. doi: 10.1136/jitc-2020-001657
  • Chiang CS, Fu SJ, Hsu CL, Jeng CJ, Tang CY, Huang YS, Tang SC. Neuronal exosomes secreted under oxygen-glucose deprivation/reperfusion presenting differentially expressed miRNAs and affecting neuronal survival and neurite outgrowth. Neuromolecular Med. 2021. 23(3):404-415. doi: 10.1007/s12017-020-08641-z
  • Wang YH, Lin CC, Hsu CL, Hung SY, Yao CY, Lee SH, Tsai CH, Hou HA, Chou WC, Tien HF. Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125. Ann Hematol. 2021. 100(2):487-498.  doi: 10.1007/s00277-020-04358-y
  • Hung SY, Lin CC, Hsu CL, Yao CY, Wang YH, Tsai CH, Hou HA, Chou WC, Tien HF. The expression levels of long non‐coding RNA KIAA0125 are associated with distinct clinical and biological features in myelodysplastic syndromes. Br J Haematol. 2021. 192(3):589-598. doi: 10.1111/bjh.17231 
  • Chung KP, Huang YL, Chen YJ, Juan YH, Hsu CL, Nakahira K, Huang YT, Lin MW, Wu SG, Shih JY, Chang YL, Yu CJ. Multi-kinase framework regulates activation of dynamin-related protein 1 to promote proliferation and invasion of lung adenocarcinoma. Mol Oncol. 2021. 15(2):560-578. doi: 10.1002/1878-0261.12843.
  • Chang YW, Hsu CL, Tang CW, Chen XJ, Hang HC, Juan HF. Multiomics reveals ectopic ATP synthase blockade induces cancer cell death via a lncRNA-mediated phospho-signaling network. 2020. Mol Cell Proteomics. 19(11):1805-1825. doi: 10.1074/mcp.RA120.002219.
  • Cheung CHY, Hsu CL, Lin TY, Chen WT, Wang YC, Huang HC, Juan HF. ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer. 2020. J Biomed Sci. 27(1):75. doi: 10.1186/s12929-020-00668-5.
  • Wang WH, Hsu CL, Huang HC, Juan HF. Quantitative phosphoproteomics reveals cell alignment and mitochondrial length change under cyclic stretching in lung cells. 2020. Int J Mol Sci. 21(11):E4074. doi: 10.3390/ijms21114074
  • Wang HY, Liu YN, Wu SG, Hsu CL, Chang TH, Tsai MF, Lin YT, Shih JY. MiR-200c-3p suppression is associated with development of acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR mutant non-small cell lung cancer via a mediating epithelial-to-mesenchymal transition (EMT) process. Cancer Biomark. 2020. 28(3):351-363. doi: 10.3233/CBM-191119.
  • Yin CF, Kao SC, Hsu CL, Chang YW, Cheung CHY, Huang HC, Juan HF. Phosphoproteome analysis reveals dynamic heat shock protein 27 phosphorylation in tanshinone IIA-induced cell death. J Proteome Res. 2020. 19(4):1620-1634. doi: 10.1021/acs.jproteome.9b00836
  • Ho TC, Wang EY, Yeh KH, Jeng YM, Horng JH, Wu LL, Chen YT, Huang HC, Hsu CL, Chen PJ, Yeh SH, Chen DS. Complement C1q mediates the expansion of periportal hepatic progenitor cells in senescence-associated inflammatory liver. Proc Natl Acad Sci U S A. 2020. 117(12):6717-6725. doi: 10.1073/pnas.1918028117
  • Shen YC, Hsu CL, Jeng YM, Ho MC, Ho CM, Yeh CP, Yeh CY, Hsu MC, Hu RH, Cheng AL. Reliability of a single-region tumor sample for evaluating the immune tumor microenvironment of hepatocellular carcinoma tumors. J Hepatol. 2020. 72:489-497. doi: 10.1016/j.jhep.2019.09.032.
  • Wang YH, Lin CC, Yao CY, Hsu CL, Hou HA, Tsai HC, Chou WC, Tien HF. A four-gene leukemic stem cell score can independently predict the prognosis of myelodysplastic syndrome patients. Blood Advances. 2020. 4(4):644-654. doi: 10.1182/bloodadvances.2019001185.
  • Lee PC, Chen ST, Kuo TC, Lin TC, Lin MC, Huang J, Hung JS, Hsu CL, Juan HF, Lee PH, Huang MC. C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer. Oncogene. 2020. 39(13):2724-2740. doi: 10.1038/s41388-020-1178-7.
  • Cheung CHY, Hsu CL, Tsuei CY, Kuo TT, Huang CT, Hsu WM, Chung YH, Wu HY, Hsu CC, Huang HC, Juan HF. Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy. Cell Death Dis. 2019. 10(11):786.
  • Chang HC*, Huang HC*, Juan HF#, Hsu CL#. Investigating the role of super-enhancer RNAs underlying embryonic stem cell differentiation. BMC Genomics. 2019. 20(Suppl 10):896.
  • Hsieh CH, Cheung CHY, Liu YL, Hou CL, Hsu CL, Huang CT, Yang TS, Chen SF, Chen CN, Hsu WM, Huang HC, Juan HF. Quantitative proteomics of Th-MYCN transgenic mice reveals aurora kinase inhibitor altered metabolic pathways and enhanced ACADM to suppress neuroblastoma progression. J Proteome Res. 2019. 18(11):3850-3866. doi: 10.1021/acs.jproteome.9b00245.
  • Hsu YC, Chen TC, Lin CC, Yuan CT, Hsu CL, Hou HA, Kao CJ, Chuang PH, Chen YR, Chou WC, Tien HF. Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials. Blood Advances. 2019. 3(15):2355-2367.
  • Chung KP, Hsu CL, Fan LC, Huang Z, Bhatia D, Chen YC, Hisata S, Cho SJ, Nakahira K, Imamura M, Choi ME, Yu CJ, Cloonan SM, Choi MK. Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis. Nat Communication. 2019. 10:3390.
  • Wu SG, Chang TH, Tsai MF, Liu YN, Hsu CL, Chang YL, Yu CJ, Shih JY. IGFBP7 drives resistance to epidermal growth factor receptor tyrosine kinase inhibition in lung cancer. Cancers (Basel). 2019. 11(1):36. doi: 10.3390/cancers11010036.
  • Ou DL, Lin YY, Hsu CL, Lin YY, Chen CW, Yu JS, Miaw SC, Hsu PN, Cheng AL, Hsu C. Development of a PD-L1-expressing orthotopic liver cancer model: implications for immunotherapy for hepatocellular carcinoma. Liver Cancer. 2019. 8(3):155-171. doi: 10.1159/000489318. 
  • Yang TW, Sahu D, Chang YW, Hsu CL, Hsieh CH, Huang HC, Juan HF. RNA-binding proteomics reveals MATR3 interacting with lncRNA SNHG1 to enhance neuroblastoma progression. J Proteome Res. 2019. 18(1):406-416. doi: 10.1021/acs.jproteome.8b00693.