Chun-Wei Lu, Mei-Hwan Wu, Jou-Kou Wang, Min-Tai Lin, Chun-An Chen, Shenn-Nan Chiu, Hsin-Hui Chiu
Adult Congenital Heart Center, Department of Pediatric Cardiology, National Taiwan University Children Hospital, Taipei, TaiwanAddress for correspondence and reprint requests:
Chun-Wei Lu, Department of Pediatric Cardiology, National Taiwan University Children Hospital, No. 8, Chung-Shan South Road, 100 Taipei, Taiwan.Fax: +886-2-2314-7450 Tel: +886-2-2312-3456 Ext. 70356E-mail: firstname.lastname@example.org
Running Title: Pregnancy in women with congenital heart disease AbstractWith advances
that have been made over the recent decades in transcatheter and surgical interventions, most patients with congenital heart disease (CHD) can survive into adulthood.
Overall, probably half of
these surviving patients are female. When these female
CHD patients reach childbearing age,
however, pregnancy management will be a major issue.
In order to meet the demands of fetal growth, the maternal cardiovascular system starts a series of adaptations
beginning in early pregnancy.
These adaptations include: decreased systemic and pulmonary vascular resistances, decreased blood pressure, expansion of the blood volume, increased heart rate and increased cardiac output.
For women with CHD, this hemodynamic alteration may increase the risks of adverse cardiovascular events as well as the fetal and neonatal complications.
Therefore,proper risk stratification and
beforeforwomen with CHD who are planning their pregnancies is an important
Congenital heart disease pregnancy
Abbreviations: CHD, congenital heart disease; WHO, World Health Organization