Wu, Chi-ShinDoctor87036.jpg

Current Appointment

Attending Physician, Division of Psychosomatic Medicine, Department of Psychiatry, National Taiwan University Hospital 

Clinical assistant professor, Department of Psychiatry, College of Medicine, National Taiwan University 

Educational Background

M.D. in Department of Medicine, National Taiwan University

Ph.D. in Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University

Training Background

Resident, Department of Psychiatry, National Taiwan University Hospital (2001~2005)

Clinical research fellow, National Health Research Institute, Taiwan (2005-2007)

Current Duty

Outpatient/ inpatient pharmacological treatment of psychiatric illness

Research in psychopharmacology and pharmacoepidemiology

Medical education in psychiatry



  1. Ma CH, Chang SS, Tsai HJ, Gau SSF, Chen IM, Liao SC, Chien YL, Hsieh MH, Wu CS*. Comparative effect of antipsychotics on risk of self-harm among patients with schizophrenia Acta Scandinavica Psychiatrica
  2. Su MH, Chen HC, Lu ML, Feng J, Chen IM, Wu CS, Chang SW, Kuo PH. Risk profiles of personality traits for suicidality among mood disorder patients and community controls Acta Scandinavica Psychiatrica (accepted)
  3. Chen TY, Winkelman J, Mao WC, Liu CL, Hsu CY, Wu CS*. The use of benzodiazepine receptor agonists and the risk of pneumonia hospitalization: a nationwide population-based, nested case-control study. Chest 153(1):161-171.
  4. Lin HT, Liu SK, Hsieh MH, Chien YL, Chen IM, Liao SC, Tsai HJ, Wu CS*. Impacts of electroconvulsive therapy on one-year outcomes in patients with schizophrenia: a controlled, population-based mirror-image study. Schizophrenia Bulletin (accepted)           
  5. Wu CS, Wu KY, Lo YR, Huang YW, Tsai, YT, Li Y, Tsai, HJ. Psychotropic Use and Risk of Stroke among Patients with Bipolar Disorders: 10-Year Nationwide Population Based Study. Journal of Affective Disorder 226, 77-84
  6. Chen IM, Lin PH, Wu VC, Wu CS, Shan JC, Chang SS, Liao SC. Suicide deaths among patients with end-stage renal disease receiving dialysis: A population-based retrospective cohort study of 64,000 patients in Taiwan Journal of affective disorder 227, 7-10


  1. Wu CS, HY Liu, HJ Tsai, SK Liu. Seizure Risk Associated with Antidepressant Treatment among Patients with Depressive Disorders: A Population-Based Case-Crossover Study. Journal of Clinical Psychiatry 78(9):e1226-e1232.
  2. Wu CS, Liao SC, Tsai YT, Chang SS, Tsai HJ. Comparative risk of self-harm hospitalization amongst depressive disorder patients using different antidepressants: a population-based cohort study in Taiwan. Psychological Medicine 47(1):81-92
  3. Wu CS, Tsai YT, Hsiung CA, Tsai HJ. Comparative risk of ventricular arrhythmia and sudden cardiac death across antidepressants in patients with depressive disorders. Journal of Clinical Psychopharmacology 37 (1): 32-39
  4. Liu CL, CS Wu*. Assessing whether the Association between Sleep Apnea and Diabetes is Bidirectional. Canadian Journal of Diabetes 41(2):197-203
  5. Wu CS, Yu SH, Lee CY, Tseng HY, Chiu YF*, Hsiung CA*. (2017) Prevalence of and risk factors for minor and major depression among community-dwelling older adults in Taiwan. International Psychogeriatrics, 29 (7)  1113-1121
  6. Wu CS, Wu HT, Tsai YT, Huang YW, Tsai HJ. (2017) Use of Antidepressants and Risk of Hospitalization for Acute Myocardial Infarction: A Nationwide Case-Crossover study Journal of Psychiatric Research, 94, 7-14
  7. Dai HJ, Su EC, Uddin M, Jonnagaddala J, Wu CS, Syed-Abdul S. Exploring Associations of Clinical and Social Parameters with Violent Behaviors among Psychiatric Patients. Journal of Biomedical Informatics 75:S149-S159
  8. Hsieh MH, Chuang PY, Wu CS, Chang CJ, Chung PF, Tang CH. (2017) Bipolar patients treated with long-acting injectable risperidone in Taiwan: A 1-year mirror-image study using a national claims database. Journal of Affective disorder 218, 327-334
  9. Chen WY, Chen LY, Liu HC, Wu CS, Yang SY, Pan CH, Tsai SY, Chen CC, Kuo CJ. Antipsychotic Medications and Stroke in Schizophrenia: a Case-Crossover Study PLoS One 12 (6), e0179424
  10. Chiu YW, Huang CW, Chen PJ, Yu NW, Tsai HJ, Wu CS, Chang CM. (2017) Trends and factors associated with antipsychotic use among elderly patients with dementia in Taiwan from 2005 to 2013 International Clinical Psychopharmacology 32 (5), 262-270
  11. Wang MYH, Tang CH, Tsai SJ, Liu CJ, Wu CS. Hepatitis B and C in Taiwanese patients with Schizophrenia: A Nationwide, Population-based study on prevalence, and healthcare utilization. J Psychol 1 (1) 1-6


  1. Wu CS, Gau SS. Association between antipsychotic treatment and advanced diabetes complications among schizophrenia patients with type 2 diabetes mellitus. Schizophrenia bulletin 42(3):703-11
  2. Wu CS, Wang SC, Yeh IJ, Liu SK. Comparative risk of seizure with first- and second-generation antipsychotics use in patients with schizophrenia and mood disorders J Clinical Psychiatry 77(5):e573-9
  3. Wu CS, Cheng IC, Feng J, Chen CL. Comparison of treatment effectiveness and medical costs for different long-acting injectable antipsychotics in patients with schizophrenia in Taiwan: A nationwide population-based cohort study. Schizophrenia research 173(1-2):37-44
  4. Wu CS, Hsieh MH, Tang CH, Chang CJ. Comparative effectiveness of long-acting injectable risperidone vs. long-acting injectable first-generation antipsychotics in bipolar disorder. Journal of affective disorder 197:189-95.
  5. Chang CM, Wu CS, Huang YW, Chau YL, Tsai HY. Utilization of psychopharmacological treatment among patients with newly diagnosed bipolar disorder from 2001 to 2010. Journal of Clinical Psychopharmacology 36(1):32-44
  6. Ma CH, Chen IM, Liao SC, Hsieh MH, Gau SSF, Lee MB, Wu CS*. Incidence and Risk Factors of Self-harm among Patients with Schizophrenia in Taiwan: A 12-year Retrospective Cohort Study. Taiwanese journal of psychiatry 30(4): 269-278


  1. Wu CS, Gau SS, Lai MS. Complications and mortality in patients with schizophrenia and diabetes: population-based cohort study. British Journal of Psychiatry 207(5):450-7
  2. Wu CS, Chang CM, Tsai YT, Huang YW, Tsai HJ. Antipsychotic Treatment and the Risk of Hip Fracture in Subjects with Schizophrenia: A 10-Year Population-Based Case-Control Study. J Clinical Psychiatry 76(9):1216-23.
  3. Wu CS, Tsai YT, Tsai HJ. Antipsychotic Drugs and the Risk of Ventricular Arrhythmia and/or Sudden Cardiac Death: A Nation-wide Case-Crossover Study. J Am Heart Assoc.2015 Feb 23;4(2). pii: e001568
  4. Wu CS, SC Wang, Liu SK. Clozapine use reduced psychiatric hospitalization and emergency room visits in patients with bipolar disorder independent of improved treatment regularity in three-year follow-up. Bipolar Disorder 17(4): 415–423
  5. Wu CS, Lu ML, Liao YT, Lee CTC, VCH Chen. Ovarian Cancer and Antidepressants. Psycho-oncology 24(5):579-84
  6. Wu SI, Chen SC*, Kao KL, Juang JM, Lin CJ, Fang CK, Wu CS*, Dewey M, Prince MJ, Stewart R. Antipsychotic Exposure prior to Acute Myocardial Infarction in Patients with Serious Mental Illness. Acta Psychiatrica Scandinavica 131(3):213-22


  1. Wu CS,  Gau SS, Lai MS. Long-term Antidepressant Use and the Risk of Type 2 Diabetes Mellitus: A Population-Based Nested Case-Control Study in Taiwan. J Clinical Psychiatry 75(1): 31-38 (IF=5.812)
  2. Wu CS, Lai MS, Gau SS, Wang SC, Tsai HJ. Concordance between patient self-reports and claims data on clinical diagnoses, medication use, and health system utilization in Taiwan. Plos One 9(12): e112257; DOI:10.1371/journal.pone.0112257 (IF=3.534)
  3. Chen PY, Liu SK, Chen CL, Wu CS *. Long-Term Statin Use and Dementia Risk in Taiwan. Journal of Geriatric Psychiatry and Neurology 2014, ;27(3):165-71 (IF=1.629)
  4. Pan YJ, Wu CS, Gau SS, Chan HY, Banerjee S. Antipsychotic discontinuation in people with dementia: a systematic review and meta-analysis of published randomized controlled studies. Dementia and Geriatric Cognitive Disorders 2014, 19;37(3-4):125-140 (IF=2.14)
  5. Liao DL, Huang CY, Hu S, Fang SC, Wu CS, Chen WT, Lee TS, Chen PC, Li CSR. Cognitive control in opioid dependence and methadone maintenance treatment. Plos One 2014 Apr 11;9(4):e94589 (IF=3.534)


  1. Wu CS, Wang SC, Gau SS, Tsai HJ, Cheng YC. Association of Stroke with the Receptor-Binding Profiles of Antipsychotics-A Case-Crossover study. Biological Psychiatry 2013, 73(5):414-421 (IF=8.283)
  2. Wu CS, Lin CC, Chang CM, Wu KY, Liang HY, Huang YW, Tsai HJ. Antipsychotic Treatment and the Occurrence of Venous Thromboembolism: A 10-Year Nationwide Registry Study. J Clinical Psychiatry 2013, 74(9): 918-924 (IF=5.812)
  3. Wu CS, Chang CM, Chen CY, Wu EC, Wu KY, Liang HY, Chao YL,Chung WI, Tsai HJ. Association between Antidepressants and Venous Thromboembolism in Taiwan. J Clinical Psychopharmacology 2013, 33(1):31-37 (IF=4.098)
  4. Wu CS, Shau WT, Chan HY, Lai MS. Persistence of antidepressant treatment for depressive disorder in Taiwan. General Hospital Psychiatry 2013, 35(3): 279-285 (IF=2.744)
  5. Wu CS, Desarkar P, Palucka A, Lunsky Y, Liu SK. Acute inpatient treatment, hospitalization course and direct costs in bipolar patients with intellectual disability. Research in Developmental Disabilities 2013, 34(11):4062-4072 (IF=2.483)
  6. Wu KY, Chang CM, Liang HY, Wu CS, Wu EC, Chen CH, Chau YL, Tsai HJ. Increased risk of developing dementia in patients with bipolar disorder: a nested matched case-control study. Bipolar Disorder 2013, 15(7):787-794
  7. Huang CY, Li CS, Fang SC, Wu CS, Liao DL: The reliability of the Chinese version of the Barratt Impulsiveness Scale version 11, in abstinent, opioid-dependent participants in Taiwan. Journal of the Chinese Medical Association 76(5):289-295, 2013 (IF=0.787)
  8. Tsai HJ, Wang SC, Tian JN, Chang TK,Ho IK, Hsiao CF, Chen CH, Tan KL, Lin L, Wu CS, Su LW, Huang CL, Yang YH, Liu ML, Lin KM, Liu YL. PXR polymorphisms interacted with CYP2B6 polymorphisms on methadone metabolites. J Clin Psychopharmacol 2013, 33(1):137-140 (IF=4.098).
  9. Chang CM, Wu ECH, Chen CY, Wu KY, Liang HY, Chau YL, Wu CS, Lin KM, Tsai HJ. Psychotropic Drugs and Risk of Motor Vehicle Accidents: a Population-based Case-Control Study. British Journal of Clinical Pharmacology 2013, 75(4):1125-33 (IF=2.958)
  10. Liu CL, Shau WY, Chang CH, Wu CS, Lai MS. Pneumonia Risk and Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers. Journal of Epidemiology 2013, 23(5):344-50 (IF= 1.858)
  11. Wang SC, Ho IK, Tsou HH, Liu SW, Hsiao CF, Chen CH, Tan HK, Lin L, Wu CS, Su LW, Huang CL, Yang YH, Liu ML, Lin KM, Liu SC, Wu HY, Kuo HW, Chen AC, Chang YS, Liu YL. Functional Genetic Polymorphisms in CYP2C19 Gene in Relation to Cardiac Side Effects and Treatment Dose in a Methadone Maintenance Cohort. OMICS: A Journal of Integrative Biology 2013, 17(10):519-26 (IF=2.730)


  1. Wu CS, Shau WY, Chan HY, Lee YC, Lai YJ, Lai MS. Utilization of Antidepressants in Taiwan: A Nationwide Population-Based Survey from 2000 to 2009. Pharmacoepidemiology and drug safety 2012, 21 (9): 980-988 (IF=2.528)
  2. Wu CS, Lin YJ, Feng J. Trends in treatment of newly treated schizophrenia-spectrum disorder patients in Taiwan from 1999 to 2006. Pharmacoepidemiology and drug safety 2012, 21 (9):989-996 (IF=2.528)
  3. Liu CL, Shau WY, Wu CS, Lai MS. Angiotensin Converting Enzyme Inhibitor /Angiotensin II Receptor Blockers and Pneumonia risk Among Stroke Patients. Journal of Hypertension 2012, 30(11):2223-9 (IF=4.021)
  4. Tian JN, Ho IK, Tsou HH, Fang CH, Hsiao CF, Chen CH, Tan HK, Lin L, Wu CS, Su LW, Huang CL, Yang YH, Liu ML, Chen YT, Liu SC, Hsu YT, Kuo HW, Liu CT, Yang YT, Chen AC, Shih YH, Liu YL. UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients. Pharmacogenomics 2012, 13(8):879-88 (IF=3.876)
  5. Chen SJ, Chao YL, Chen CY, Chang CM, Wu EC, Wu CS, Yeh HH, Chen CH, Tsai HJ. Prevalence of autoimmune diseases in in-patients with schizophrenia: nationwide population-based study.           British Journal of Psychiatry 2012, 200:374-380 (IF=6.619)
  6. Chang CM, Wu KY, Liang HY, Wu EC, Chen CY, Wu CS, Chen SJ, Chang TK, Tsai HJ. Adherence Patterns with First- Versus Second-Generation Antipsychotics for Newly Diagnosed Schizophrenia in Taiwan. Psychiatric Services 2012, 63:504–507 (IF=2.388)


  1. Wu CS, Wang SC, Cheng YC, Gau SS. Association of cerebrovascular events with antidepressant use: A case-crossover study. American Journal of Psychiatry 2011, 168:511–521 (IF=12.759)
  2. Wu CS, Ting TT, Wang SC, Chang IS, Lin KM: Effect of Benzodiazepine Discontinuation on Dementia Risk, American Journal of Geriatric Psychiatry 2011, 19:151-159 (IF=3.566)
  3. Wu CS, Lin YJ, Liu SK. Benzodiazepine use among patients with schizophrenia in Taiwan: a nationwide population-based survey. Psychiatric Services 2011, 62:908–914 (IF=2.388)
  4. Wang SC, Ho IK, Tsou HH, Tian JN, Hsiao CF, Chen CH, Tan H.KL, Lin L, Wu CS, Su LW, Huang CL, Yang YH, Liu ML, Lin KM, Chen CY, Liu SC, Wu HY, Chan HW, Tsai MH, Lin PS, Liu YL. CYP2B6 polymorphisms influence the plasma concentration and clearance of the methadone s-enantiome. Journal of Clinical Psychopharmacology 2011, 31: 463-469 (IF=4.857)
  5. Lin KM, Chiu YF, Tsai IJ, Chen CH, Shen WW, Liu SC, Lu SC, Liu CY, Hsiao MC, Tang HS, Liu SI, Chang LH, Wu CS, Tsou HH, Tsai MH, Chen CY, Wang SM, Kuo HW, Hsu YT, Liu YL: ABCB1 Gene Polymorphisms are Associated with the Severity of Major Depressive Disorder and its Response to Escitalopram treatment, Pharmacogenetics and Genomics 2011, 21(4):163-170 (IF=3.865)

2010 and before

  1. Lin KM, Tsou HH, Tsai IJ, Hsiao MC, Hsiao CF, Liu CY, Shen WW, Tang HS, Fang CK, Wu CS, Lu SC, Kuo HW, Liu SC, Chan HW, Hsu YT, Tian JN, Liu YL: CYP1A2 genetic polymorphisms are associated with treatment response to the antidepressant paroxetine, Pharmacogenomics 2010, 11: 1535-1543 (IF=3.876)
  2. Tsai MH, Lin KM, Hsiao MC, Shen WW., Lu ML, Tang HS, Fang CK, Wu CS, Lu SC, Liu SC, Chen YC: Cytochrome P-450 Enzyme Genetic Polymorphisms Influence Antidepressant Escitalopram Metabolism and Treatment Response, Pharmacogenomics 2010, 11: 537–546 (IF=3.876)
  3. Wu CS, Wang SC, Chang IS, Lin KM: The Association between Dementia and Long-term Use of Benzodiazepine in the Elderly: A nested case-control study using claims data, American Journal of Geriatric Psychiatry 2009, 17: 614-620 (IF=3.566)
  4. Wu CS, Liao SC, Lin KM, Tseng M. MC, Wu E. CH, Liu SK: Multi-dimensional Assessments of Impulsivity I Subjects with History of Suicidal Attempts, Comprehensive Psychiatry 2009, 50: 315–321 (IF=2.377)
  5. Lu TC, Chu TC, Wu CS, Tsai KC, Chen WJ: Neuroleptic malignant syndrome after the use of venlafaxine in a patient with generalized anxiety disorder J Formos Med Assoc 2006, 105(1):90-3 (IF= 1.125)
  6. Wu CS, Wu CZ, Liu SK: An open trial of Risperidone shifting from oral form to long-acting injection from in patients with schizophrenia, Taiwanese Journal of Psychiatry 2005, 19: 314​