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吳瑞美教授研究成果

吳瑞美教授(Ruey-Meei Wu)

  • Fung VS, Herawati L, Wan Y; Movement Disorder Society of Australia Clinical Research and Trials Group; QUEST-AP Study Group. (2009) Quality of life in early Parkinson's disease treated with levodopa/carbidopa/entacapone. Mov Disord. 24:25-31.

 

  • Lee MJ, Mata IF, Lin CH, Tzen KY, Lincoln SJ, Bounds R, Lockhart PJ, Hulihan MM, Farrer MJ, Wu RM*. (2009) Genotype-Phenotype correlates in Taiwanese patients with early-onset recessive parkinsonism. Mov Disord. 24:104-108.

 

  • Taylor JM, Wu RM, Lin CH, Delatycki MB, Lockhart PJ. (2009) Lack of evidence for association of a parkin promoter polymorphism with early-onset Parkinson's disease in a Chinese population. Parkinsonism Relat Disord. 15:149-152.

 

  • Ross OA, Spanaki C, Griffith A, Lin CH, Kachergus J, Haugarvoll K, Latsoudis H, Plaitakis A, Ferreira JJ, Sampaio C, Bonifati V, Wu RM, Zabetian CP, Farrer MJ. (2009) Haplotype analysis of Lrrk2 R1441H carriers with Parkinsonism. Parkinsonism Relat Disord. 15:466-467.

 

  • Taylor JM, Wu RM, Farrer MJ, Delatycki MB, Lockhart PJ. (2009) Analysis of PArkin Co-Regulated Gene in a Taiwanese-Ethnic Chinese cohort with early-onset Parkinson's disease. Parkinsonism Relat Disord. 15:417-421.

 

  • Fan PC, Kuo PH, Chang SH, Lee WT, Wu RM, Chiou LC. (2009) Plasma calcitonin gene-related peptide in diagnosing and predicting pediatric migraine. Cephalalgia. 29:883-890.

 

  • Tai CH, Yen RF, Lin CH, Yen KY, Yip PK, Wu RM, Lee MJ. (2009) Focal brain glucose hypermetabolism in myoclonus-dystonia syndrome caused by an epsilon-sarcoglycan gene mutation. Parkinsonism Relat Disord. 15:614-616.

 

  • Tan EK, Lin CH, Tai CH, Tan LC, Chen ML, Li R, Lim HQ, Pavanni R, Yuen Y, Prakash KM, Zhao Y, Wu RM*. (2009) Non-synonymous GIGYF2 variants in Parkinson's disease from two Asian populations. Hum Genet. 126:425-430.

 

  • Tan EK, Peng R, Wu YR, Wu RM, Wu-Chou YH, Tan LC, An XK, Chen CM, Fook-Chong S, Lu CS. (2009) LRRK2 G2385R modulates age at onset in Parkinson's disease: A multi-center pooled analysis. Am J Med Genet B Neuropsychiatr Genet. 150B:1022-1023.

 

  • Cobb SA, Wider C, Ross OA, Mata IF, Adler CH, Rajput A, Rajput AH, Wu RM, Hauser R, Josephs KA, Carr J, Gwinn K, Heckman MG, Aasly JO, Lynch T, Uitti RJ, Wszolek ZK, Kapatos G, Farrer MJ. (2009) GCH1 in early-onset Parkinson's disease. Mov Disord. 24:2070-2075.

 

  • Chan HF, Chen ML, Su JJ, Ko LC, Lin CH, Wu RM. (2010) A novel neuropsychiatric phenotype of KCNJ2 mutation in one Taiwanese family with Andersen-Tawil syndrome. J Hum Genet. 55:186-188.

 

  • Vilariño-Güell C, Wider C, Aasly JO, White LR, Rajput A, Rajput AH, Lynch T, Krygowska-Wajs A, Jasinska-Myga B, Opala G, Barcikowska M, Czyzewski K, Wu RM, Uitti RJ, Wszolek ZK, Farrer MJ, Ross OA. (2010) Association of pyridoxal kinase and Parkinson disease. Ann Neurol. 67:409-411.

 

  • Tan EK, Peng R, Teo YY, Tan L, Angeles D, Ho P, Chen ML, Lin CH, Mao XY, Chang XL, Prakash KM, Liu JJ, Au WL, Le WD, Jankovic J, Burgunder JM, Zhao Y, Wu RM*. (2010) Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter studyHum Mutat. 31:561-568.

 

  • Wu PF, Kuo KT, Kuo LT, Lin YT, Lee WC, Lu YS, Yang CH, Wu RM, Tu YK, Tasi JC, Tseng HM, Tseng SH, Cheng AL, Lin CH. (2010) O(6)-Methylguanine-DNA methyltransferase expression and prognostic value in brain metastases of lung cancers. Lung Cancer. 68:484-490. 

 

  • Yu RL, Wu RM, Tai CH, Lin CH, Hua MS. (2010) Feeling-of-knowing in episodic memory in patients with Parkinson's disease with various motor symptomsMov Disord. 25:1034-1039.

 

  • Tan EK, Lu CS, Peng R, Teo YY, Wu-Chou YH, Chen RS, Weng YH, Chen CM, Fung HC, Tan LC, Zhang ZJ, An XK, Lee-Chen GJ, Lee MC, Fook-Chong S, Burgunder JM, Wu RM, Wu YR. (2009) Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese. Neurobiol Aging. 2009 Mar 27. [Epub ahead of print].

 

  • Tai CH, Wu RM, Lin CH, Pan MK, Chen YF, Liu HM, Lu HH, Tsai CW, Tseng SH. (2010) Deep brain stimulation therapy for Parkinson's disease using frameless stereotaxy: comparison with frame-based surgery. Eur J Neurol. In Press

 

  • Huang,SL; Hsieh,CL; Wu,RM; Tai,CH; Lin,CH; Lu,WS . Minimal Detectable Change of     the Timed ""Up & Go"" Test and the Dynamic Gait Index in People With Parkinson     Disease. Pysical Therapy 2011  JAN;91 (1) :114-121

 

  • Lin,CH; Chen,ML; Chen,GS; Tai,CH; Wu,RM. Novel variant Pro143Ala in HTRA2     contributes to Parkinson's disease by   inducing hyperphosphorylation of  HTRA2 protein in     mitochondria. Human Genetics 2011 Dec;130 (6) :817-827

 

  • Lin,CH; Wu,RM; Tai,CH; Chen,ML; Hu,FC . Lrrk2 S1647T and BDNF V66M interact     with environmental factors to  increase risk of Parkinson's disease. Parkinsonism & Related     Disorders,2011 Feb;17 (2) :84-88

 

  • Ross,OA; Soto-tolaza,AI; Heckman,MG; Aasly,JO; Abahuni,N; Annesi,G; Bacon,JA;      Bardien,S; Bozi,M; Brice,A; Brighina,L; VanBroeckhoven,C;Carr,J; Chartier-Harlin,MC;     Dardiotis,E; Dickson,DW; Diehl,NN; Elbaz,A; Ferrarese,C; Ferraris,A; Fiske,B;     Gibson,JM; Gibson,R; Hadjigeorgiou,GM; Hattori,N; Ioannidis,JPA; Jasinska-Myga,B;     Jeon,BS; Kim,YJ; Klein,C; Kruger,R; Kyratzi,E; Lesage,S; Lin,CH; Lynch,T;      Maraganore,DM; Mellick,GD; Mutez,E; Nilsson,C;Opala,G; Park,SS; Puschmann,A;     Quattrone,A; Sharma,M; Silburn,PA; Sohn,YH; Stefanis,L; Tadic,V; Theuns,J;     Tomiyama,H; Uitti,RJ; Valente,EM; vandeLoo,S; Vassilatis,DK; Vilarino-Guell,C;     White,LR; Wirdefeldt,K; Wszolek,ZK; Wu,RM; Farrer,MJ . Association of LRRK2 exonic     variants with susceptibility to Parkinson's   disease: a case-control study. Lancet Neurology     2011 Oct;10(10) :898-908

 

  • Tai,CH; Wu,RM; Liu,HM; Tsai,CW; Tseng,SH. Meige Syndrome Relieved by Bilateral      Pallidal Stimulation With Cycling Mode: Case Report. Neurosurgery 2011 Dec;69     (6) :E1333-E1337

 

  • Yen,CY; Lin,KH; Hu,MH; Wu,RM; Lu,TW; Lin,CH .Effects of Virtual Reality-Augmented      Balance Training on Sensory Organization and Attentional Demand for Postural Control in     People With Parkinson Disease: A Randomized Controlled Trial. Physical Therapy 2011      Jun;91 (6) :862-874

 

  • Yu RL, Wu RM, Chiu MJ, Tai CH, Lin CH, Hua MS. Advanced Theory of Mind in patients at early stage of Parkinson's disease.        PARKINSONISM & RELATED DISORDERS. 2012.Jan;18:21-24. (Corresponding author)

 

  • Yu RL, Wu RM, Tai CH, Lin CH, Cheng TW, Hua MS. Neuropsychological profile in patients with early stage of Parkinson's disease in Taiwan.  Parkinsonism Relat Disord. 2012 Dec;18(10):1067-72.

 

  • Chen KH, Lin CH*, Wu RM. Psychotic-affective symptoms and multiple system atrophy expand phenotypes of spinocerebellar ataxia type 2.     BMJ Case Rep. 2012 Mar 20;doi:pii: bcr1020115061.

 

  • Lai HJ, Lin CH*, Wu RM. Early-onset autosomal-recessive parkinsonian-pyramidal syndrome. Acta Neurol Taiwan. 2012 Sep;21(3):99-107.

 

  • Lin CH, Chen ML, Tai YC, Yu CY, Wu RM. Reaffirmation of GAK, but not HLA-DRA, as a Parkinson's disease susceptibility gene in a Taiwanese population. Am J Med Genet B Neuropsychiatr Genet. 2013 Dec;162(8):841-846.

 

  • Heckman MG, Soto-Ortolaza AI, Aasly JO, Abahuni N, Annesi G, Bacon JA, Bardien S, Bozi M, Brice A, Brighina L, Carr J, Chartier-Harlin MC, Dardiotis E, Dickson DW, Diehl NN, Elbaz A, Ferrarese C, Fiske B, Gibson JM, Gibson R, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Boczarska-Jedynak M, Jasinska-Myga B, Jeon BS, Kim YJ, Klein C, Kruger R, Kyratzi E, Lesage S, Lin CH, Lynch T, Maraganore DM, Mellick GD, Mutez E, Nilsson C, Opala G, Park SS, Petrucci S, Puschmann A, Quattrone A, Sharma M, Silburn PA, Sohn YH, Stefanis L, Tadic V, Theuns J, Tomiyama H, Uitti RJ, Valente EM, Van Broeckhoven C, van de Loo S, Vassilatis DK, Vilariño-Güell C, White LR, Wirdefeldt K, Wszolek ZK, Wu RM, Hentati F, Farrer MJ, Ross OA; Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium. Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium. Mov Disord. 2013 Oct;28(12):1740-1744.

 

  • Lin CH, Wu RM, Chang HY, Chiang YT, Lin HH. Preceding pain symptoms and Parkinson's disease: a nationwide population-based cohort study. Eur J Neurol. 2013 Oct;20(10):1398-1404.

 

  • Lin CH, Chen ML, Yu CY, Wu RM. RIT2 variant is not associated with Parkinson's disease in a Taiwanese population. Neurobiol Aging. 2013 Sep;34(9):2236.e1-3.

 

  • Lin CH, Wu VC, Li WY, Sy HN, Wu SL, Chang CC, Chiu PF, Lion HH, Lin CY, Chang HW, Lin SY, Wu KD, Chen YM, Wu RM. Restless legs syndrome in end-stage renal disease: a multicenter study in Taiwan. Eur J Neurol. 2013 Jul;20(7):1025-1031.

 

  • Lee YC, Lin CH, Wu RM, Lin MS, Lin JW, Chang CH, Lai MS. Discontinuation of statin therapy associates with Parkinson disease: a population-based study. Neurology. 2013 Jul 30;81(5):410-416.

 

  • McNeill A, Wu RM, Tzen KY, Aguiar PC, Arbelo JM, Barone P, Bhatia K, Barsottini O, Bonifati V, Bostantjopoulou S, Bressan R, Cossu G, Cortelli P, Felicio A, Ferraz HB, Herrera J, Houlden H, Hoexter M, Isla C, Lees A, Lorenzo-Betancor O, Mencacci NE, Pastor P, Pappata S, Pellecchia MT, Silveria-Moriyama L, Varrone A, Foltynie T, Schapira AH. Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis. PLoS One. 2013 Jul 23;8(7):e69190.

 

  • Lin CH, Chen ML, Lai TT, Tai CH, Wu RM. Mutational analysis of FBXO7 gene in Parkinson's disease in a Taiwanese population. Neurobiol Aging. 2013 Jun;34(6):1713.e1-4.

 

  • Lin CH, Ou YK, Wu RM, Liu YC. Predictors of road crossing safety in pedestrians with Parkinson's disease. Accid Anal Prev. 2013 Mar;51:202-207.

 

  • Chien WL, Lee TR, Hung SY, Kang KH, Wu RM, Lee MJ, Fu WM. Increase of oxidative stress by a novel PINK1 mutation, P209A. Free Radic Biol Med. 2013 May;58:160-169.

 

  • Trinh J, Vilariño-Güell C, Donald A, Shah B, Yu I, Szu-Tu C, Aasly JO, Wu RM, Hentati F, Rajput AH, Rajput A, Farrer MJ. STX6 rs1411478 is not associated with increased risk of Parkinson's disease. Parkinsonism Relat Disord. 2013 May;19(5):563-565.

 

  • Yu RL, Wu RM. Social brain dysfunctions in patients with Parkinson's disease: a review of theory of mind studies. Transl Neurodegener. 2013 Mar 28;2(1):7.

 

  • Wu MC, Yen RF, Lin CH, Wu RM. Hemiballism in a patient with parietal lobe infarction. Neurology. 2013 Jan 15;80(3):e22.

 

  • Lin CH, Lin JW, Liu YC, Chang CH, Wu RM. (2014) Risk of Parkinson's disease following severe constipation: a nationwide population-based cohort study. Parkinsonism Relat Disord. 20:1371-1375.

 

  • Chen ML, Wu RM, Tai CH, Lin CH. (2014) Mutational analysis of angiogenin gene in Parkinson's disease. PLoS One. 9:e112661.

 

  • Pan MK, Tai CH, Liu WC, Pei JC, Lai WS, Kuo CC. (2014) Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits. J Clin Invest. 124:4629-4641.

 

  • Lee YC, Lin CH, Wu RM, Lin JW, Chang CH, Lai MS. (2014) Antihypertensive agents and risk of Parkinson's disease: a nationwide cohort study. PLoS One. 9:e98961.

 

  • Chang CH, Lin JW, Lin CH, Chen HC, Hwang JJ, Lai MS. (2014) Effectiveness and safety of extracranial carotid stent placement: A nationwide self-controlled case-series study. J Formos Med Assoc. pii: S0929-6646(14)00153-3.

 

  • Lin CH, Chen KH, Chen ML, Lin HI, Wu RM. (2014) Vitamin D receptor genetic variants and Parkinson's disease in a Taiwanese population. Neurobiol Aging. 35:1212.e11-13.

 

  • Lin CH, Chen TF, Chiu MJ, Lin HI, Wu RM. (2014) Lack of c9orf72 repeat expansion in taiwanese patients with mixed neurodegenerative disorders. Front Neurol. 5:59.

 

  • Lin CH, Chen ML, Wu VC, Li WY, Sy HN, Wu SL, Chang CC, Chiu PF, Liou HH, Lin CY, Chang HW, Lin SY, Wu KD, Chen YM, Wu RM. (2014) Association of candidate genetic variants with restless legs syndrome in end stage renal disease: a multicenter case-control study in Taiwan. Eur J Neurol. 21:492-498.

 

  • Chen ML, Lin CH, Lee MJ, Wu RM. (2014) BST1 rs11724635 interacts with environmental factors to increase the risk of Parkinson's disease in a Taiwanese population. Parkinsonism Relat Disord. 20:280-283.

 

  • Vilariño-Güell C, Rajput A, Milnerwood AJ, Shah B, Szu-Tu C, Trinh J, Yu I, Encarnacion M, Munsie LN, Tapia L, Gustavsson EK, Chou P, Tatarnikov I, Evans DM, Pishotta FT, Volta M, Beccano-Kelly D, Thompson C, Lin MK, Sherman HE, Han HJ, Guenther BL, Wasserman WW, Bernard V, Ross CJ, Appel-Cresswell S, Stoessl AJ, Robinson CA, Dickson DW, Ross OA, Wszolek ZK, Aasly JO, Wu RM, Hentati F, Gibson RA, McPherson PS, Girard M, Rajput M, Rajput AH, Farrer MJ. (2014) Hum Mol Genet. 23:1794-1801.

 

  • Yang YC, Tai CH, Pan MK, Kuo CC. (2014) The T-type calcium channel as a new therapeutic target for Parkinson's disease. Pflugers Arch. 466:747-755.

 

  • Yu CY, Wu RM. (2014) Application of the University Of Pennsylvania Smell Identification Test (traditional Chinese version) for detecting olfactory deficits in early Parkinson's disease in a Taiwanese cohort. J Parkinsons Dis. 4:175-180.

 

  • Geurtsen GJ, Hoogland J, Goldman JG, Schmand BA, Tröster AI, Burn DJ, Litvan I; MDS Study Group on the Validation of PD-MCI Criteria. (2014) Parkinson's disease mild cognitive impairment: application and validation of the criteria. J Parkinsons Dis. 4:131-137.

 

  • Wu RM, Lin CH, Lin HI. (2014) The p.L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease. Neurology. 82:283.

 

  • Heckman MG, Elbaz A, Soto-Ortolaza AI, Serie DJ, Aasly JO, Annesi G, Auburger G, Bacon JA, Boczarska-Jedynak M, Bozi M, Brighina L, Chartier-Harlin MC, Dardiotis E, Destée A, Ferrarese C, Ferraris A, Fiske B, Gispert S, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Jeon BS, Kim YJ, Klein C, Kruger R, Kyratzi E, Lin CH, Lohmann K, Loriot MA, Lynch T, Mellick GD, Mutez E, Opala G, Park SS, Petrucci S, Quattrone A, Sharma M, Silburn PA, Sohn YH, Stefanis L, Tadic V, Tomiyama H, Uitti RJ, Valente EM, Vassilatis DK, Vilariño-Güell C, White LR, Wirdefeldt K, Wszolek ZK, Wu RM, Xiromerisiou G, Maraganore DM, Farrer MJ, Ross OA; Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium. (2014) Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants. Neurobiol Aging. 35:266.e5-14.

 

  • Chin-Hsien Lin, Hiu-Ngar Sy, Hong-Wei Chang, Hung-Hsiang Liou, Chien-Yu Lin, Vin-Cent Wu, Shey-Lin Wu, Chia-Chu Chang, Ping-Fang Chiu, Wen-Yi Li, Sen-Yong Lin, Kwan-Dun Wu, Yung-Ming Chen, Ruey-Meei Wu. Restless legs syndrome is associated with cardio/cerebrovascular events and mortality in end-stage renal disease. European Journal of Neurology 2015 Jan;22(1):142-9.

 

  • Chin-Hsien Lin, Hang-I Lin, Meng-Ling Chen, Ruey-Meei Wu. COQ2 p.V393A variant, rs148156462, is not associated with Parkinson's disease in a Taiwanese population. Neurobiology of Aging 2015 Jan;36(1):546.e17-8.

 

  • Chin-Hsien Lin, Eng-King Tan, Chih-Chao Yang, Zhao Yi, Ruey-Meei Wu. COQ2 gene variants associate with cerebellar subtype of multiple system atrophy in Chinese. Movement Disorders 2015 Mar;30(3):436-7. 

 

  • Lin CH, Wu RM. Biomarkers of cognitive decline in Parkinson's disease. Parkinsonism & Related Disorder 2015 May;21(5):431-43.

 

  • Chin-Hsien Lin, Hsun Li, Yi-Nan Lee, Ying-Ju Cheng, Ruey-Meei Wu, Cheng-Ting Chien. Lrrk regulates the dynamic profile of dendritic Golgi outposts through the golgin Lava lamp. Journal of Cell Biology 2015 Aug 3;210(3):471-83. 

 

  • Chin-Hsien Lin, Jou-Wei Lin, Ying-Chun Liu, Chia-Hsuin Chang, Ruey-Meei Wu. Risk of Parkinson's disease following anxiety disorders: A nationwide population-based cohort study. European Journal of Neurology 2015 Sep;22(9):1280-7. 

 

  • Weng-Ming Liu, Ruey-Meei Wu, Jou-Wei Lin, Chia-Hsuin Chang, Chin-Hsien Lin* Time trends in the prevalence and incidence of Parkinson's disease in Taiwan: A nationwide, population-based study. Journal of the Formosan Medical Association 2015 Jun 26. pii: S0929-6646(15)00184-9.

 

  • Kai-Hsiang Chen, Ruey-Meei Wu, Hang-I Lin,Chun-Hwei Tai, Chin-Hsien Lin* Mutational analysis of SYNJ1 gene (PARK20) in Parkinson's disease in a Taiwanese population. Neurobiology of Aging 2015 Oct;36(10):2905.e7-8. 

 

  • Liu WM, Lin RJ, Yu RL, Tai CH, Lin CH, Wu RM. The impact of nonmotor symptoms on quality of life in patients with Parkinson's disease in Taiwan. Neuropsychiatr Dis Treat. 2015 Nov 11;11:2865-73.

 

  • Yang WC, Hsu WL, Wu RM and Lin KH. Immediate Effects of Clock-Turn Strategy on the Pattern and Performance of Narrow Turning in Persons With Parkinson Disease. J Neurol Phys Ther. 2016;40:249-56.

 

  • Yu RL, Tan CH, Lu YC and Wu RM. Aldehyde dehydrogenase 2 is associated with cognitive functions in patients with Parkinson's disease. Sci Rep. 2016;6:30424.

 

  • Yang WC, Hsu WL, Wu RM, Lu TW and Lin KH. Motion analysis of axial rotation and gait stability during turning in people with Parkinson's disease. Gait Posture. 2016;44:83-8.

 

  • Hsien-Han Lin, Ruey-Meei Wu, Han-I Lin, Meng-Ling Chen, Chun-Hwei Tai, Chin-Hsien Lin*. Lack of RAB39B mutations in early-onset and familial Parkinson's disease in a Taiwanese cohort. Neurobiology of Aging 2017 Feb;50:169.e3-169.

 

  • Tian-Sin Fan, Chin-Hsien Lin*, Hang-I Lin, Meng-Ling Chen, Ruey-Meei Wu. Lack of TMEM230 mutations in patients with familial and sporadic Parkinson's disease in a Taiwanese population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2017 Oct;174(7):751-756