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研究成果

李銘仁教授(Ming-Jen Lee)

  • Tai CH, Yen RF, Lin CH, Yen KY, Yip PK, Wu RM, Lee MJ. Focal brain glucose hypermetabolism in myoclonus-dystonia syndrome caused by an epsilon-sarcoglycan gene mutation. Parkinsonism Relat Disord. 2009

 

  • Yeh WL, Lu DY, Lee MJ, Fu WM. Leptin induces migration and invasion of glioma cells through mmp-13 production. Glia. 2009;57:454-464

 

  • Lee MJ, Ignacio F. Mata, Lin CH, Tzen KY, Sarah J. Lincoln, Rebecca Bounds, Paul J. Lockhart, Mary M. Hulihan, Matthew J. Farrer, Wu RM. Genotype-Phenotype correlates in    Taiwanese patients with early-onset  recessive Parkinsonism. Movement Disorder 2009 Jan  15;24(1):104-8

 

  • Yeh WL, Lu DY, Lee MJ, Fu WM. Leptin induces migration and invasion  of glioma cells     through MMP-13 production. Glia. 2009 Mar; 57(4):454-64.

 

  • Tai CH, Yen RF, Liu CH, Yen KY, Yip PK, Wu RM, Lee MJ. Focal brainglucose    hypermetabolism in myoclonus-dystonia syndrome caused by an  epsilon-sacroglycan gene     mutation. Parkinsonism Relat Disord. 2009  Sep;15(8):614-6

 

  • Lee MJ, Chang CP, Lee YH, Wu YC, Tseng HW, Tung YY, Chen YH, We MZ,  Kuo LT, Stephenson DA, Hung SI, Wu JY, Chang C, Chen YT, Chern Y.Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus. PLoS One 2009 Nov17;4(11):e7868.

 

  • Yang Naomi CC*, Lee MJ*, Chao CC*, Chuang YT, Lin WM, Chang MF, Hsieh PC, Kan     HW, Lin YH, Yang CC, Chiu MJ, Liou HH, Hsieh ST. Clinical presentations and skin     denervation in amyloid neuropathy due to transthyretin Ala97Ser. NEUROLOGY 2010 Aug 10;75(6):532-8  (*  Co-the first)

 

  • Chen YW, Lee MJ, Smith EE. Cerebral amyloid angiopathy in east and west. International     Journal of Stroke 2010 Oct;5:403-411

 

  • Weber J A, Baxter DH, Zhang Shile, Huang DY., Huang KH, Lee MJ, Galas DJ, Wang K. The MicroRNA Spectrum in 12 Body Fluids. Clinical Chemistry 2010 (in press)

 

  • Chien,WL; Lee,TR; Hung,SY; Kang,KH; Lee,MJ; Fu,WM. Impairment Of  Oxidative   Stress-Induced Heme Oxygenase-1 Expression By The Defect Of Parkinson-Related Gene      Of PINK1. Journal Of Neurochemistry 2011MAY;117(4) :643-653

 

  • Kuo,HC; Huang,CC; Chu,CC; Lee,MJ; Chuang,WL; Wu,CL; Wu,T; Ning,HC; Liu,CY.     Neurological Complications of Acute Intermittent Porphyria. European neurology 2011;66    (5) :247-252

 

  • Lee,MJ; Chen,TF; Cheng,TW; Chiu,MJ . rs5848 Variant of Progranulin Gene Is a Risk of      Alzheimer's Disease in   the Taiwanese Population. Neurodegenerative Diseases 2011;8      (4) :216-220

 

  • Lin,CSY; Lee,MJ; Park,SB; Kiernan,MC . Purple pigments: The pathophysiology of acute      porphyric neuropathy. Clinical Neurophysiology 2011 Dec;122 (12) :2336-2344

 

  • Wang,HF; Shih,YT; Chen,CY; Chao,HW; Lee,MJ; Hsueh,YP. Valosin-containing protein and neurofibromin interact to regulate dendritic spine density. Journal Of Clinical  Investigation 2011 Dec;121 (12) :4820-4837

 

  • Wu,YY; Cheng,IHJ; Lee,CC; Chiu,MJ; Lee,MJ; Chen,TF; Hsu,JL.Clinical Phenotype of      G206D Mutation in the Presenilin 1 Gene in   Pathologically Confirmed Familial      Alzheimer's Disease. Journal Of Alzheimers Disease 2011;25 (1) :145-150

 

  • Lee MJ, Cho JH, Galas DJ, Wang K.. The systems biology of neurofibromatosis type 1 - Critical roles for microRNA.. Exp Neurol. 2012 Jun;235(2):464-8.

 

  • Lee YC, Lee MJ, Yu HY, Chen C, Hsu CH, Lin KP, Liao KK, Chang MH, Liao YC, Soong BW. PRRT2 mutations in paroxysmal kinesigenic dyskinesia with infantile convulsions in a Taiwanese cohort. PLoS One. 2012;7(8):e38543.

 

  • Wu, MT Huang, PY Yen, CT Chen, CC Lee, MJ A Novel SCN9A Mutation Responsible for Primary Erythromelalgia and Is Resistant to the Treatment of Sodium Channel Blockers PLoS One 2013

 

  • Chien, WL Lee, TR Hung, SY Kang, KH Wu, RM Lee, MJ(corresponding author)* Fu, WM* Increase of oxidative stress by a novel PINK1 mutation, P209A Free Radic. Biol. Med. 2013

 

  • Chien, WL Kang, KH Lee, MJ Fu, WM Impairment of inflammatory cytokine-induced manganese superoxide dismutase expression by the PINK1 G309D mutation Acta Pharmacol.Sin 2013

 

  • Ming-Jen Lee,  Ming-Kai Pan Microstructural integrity of cerebral fiber tracts in hereditary spastic paraparesis with SPG11 mutation American Journal of Neuroradiology , vol. 34, no. 5 , page 990-996 , 2013

 

  • Ming-Jen Lee Molecular pathogenesis of neurofibromatosis type 1 Neurofibromatosis Type 1: Symptoms, Treatment and Prognosis , page 1-22 , 2013

 

  • KUO-LIONG CHIEN, Ming-Jen Lee Overweight modulates APOE and APOA5 alleles on the risk of severe hypertriglyceridemia Clinica Chimica Acta , vol. 416 , page 31-35 , 2013

 

  • Ming-Jen Lee The influences of reserpine and imipramine on the 5-HT2 receptor binding site and its coupled second messenger in rat cerebral cortex. The Chinese journal of physiology , vol.56, no. 4 , page 199-208 , 2013

 

  • Chih-Chao Yang,   Ming-Jen Lee A novel XK gene mutation in a Taiwanese family with McLeod syndrome Journal of the Neurological Sciences , vol. 340, no. 1-2 , page 221-224 , 2014

 

  • Ruey-Meei Wu,  Ming-Jen Lee BST1 rs11724635 interacts with environmental factors to increase the risk of Parkinson's disease in a Taiwanese population Parkinsonism and Related Disorders , vol. 20, no. 3 , page 280-283 , 2014

 

  • Ming-Jen Lee A case of familial amyloidotic polyneuropathy with a rare Phe33Leu mutation in the TTR gene Journal of the Formosan Medical Association , vol. 113, no. 8 , page 575-576 , 2014

 

  • Chien CH, Lee MJ, Liou HC, Liou HH and Fu WM. Microglia-Derived Cytokines/Chemokines Are Involved in the Enhancement of LPS-Induced Loss of Nigrostriatal Dopaminergic Neurons in DJ-1 Knockout Mice. PLoS One.

蔡力凱臨床教授(Li-Kai Tsai)

  • Tsai LK, Yang CC, Ting JH, Hwu WL, Tsai MS, Li H. High correlation of SMN in leukocytes and spinal cord. J. Pediatr. 2009;154:303-305. (SCI)

 

  • Tsai LK, Yeh SJ, Chen YC, Liu HM, Jeng JS. Screen for intracranial dural arteriovenous fistulae with carotid duplex sonography. J. Neurol. Neurosurg. Psychiatry 2009;80:1225-1229. (SCI)

 

  • Yeh SJ, Tsai LK*, Jeng JS. Clinical and Carotid Ultrasonographic Features of Intracranial Dural Arteriovenous Fistulae in Patients with and without Pulsatile Tinnitus. J. Neuroimaging 2009, May online (in press). (SCI)

 

  • Jeng JS, Tang SC, Deng IC, Tsai LK, Yeh SJ, Yip PK. Stroke center characteristics which influence the administration of thrombolytic therapy for acute ischemic stroke: A national survey of stroke centers in Taiwan. J. Neurol. Sci. 2009;281:24-27. (SCI)

 

  • Hon CT, Tsai LK*, Jeng JS. Patterns of Acute Cerebral Infarct in Patients with Active Malignancy Using Diffusing Weighted Image. Cerebrovasc. Dis. 2009;28:411-416. (SCI)

 

  • Tsai LK, Leng Y, Wang  ZF, Leeds P, Chuang DM. Mood stabilizers valproic acid and lithium enhance mesenchymal stem cell migration via distinct mechanisms. Neuropsychopharmacology. 2010; July online (in press). (SCI)

 

  • Tsai LK, Leng Y, Wang Z, Leeds P, Chuang DM. Mood stabilizers  valproic acid and lithium enhance mesenchymal stem cell migration via  distinct mechanisms. Neuropsychopharmacology. 2010;35:2225-2237.

 

  • Hsieh FI, Lien LM, Chen ST, et al and Taiwan Stroke Registry  Investigators (Jeng JS, Yeh SJ, Tsai LK et al). Get with the  guidelines-stroke performance indicators: surveillance of stroke care  in the Taiwan Stroke Registry: Get With the Guidelines-Stroke in  Taiwan. Circulation 2010;122:1116-1123.

 

  • Tsai,LK; Wang,ZF; Munasinghe,J; Leng,Y; Leeds,P; Chuang,DM. Mesenchymal Stem Cells   Primed With Valproate and Lithium Robustly Migrate to Infarcted Regions and Facilitate   Recovery in a Stroke Model. STROKE 2011 OCT;42 (10) :2932-U406

 

  • Wang,ZF; Leng,Y; Tsai,LK; Leeds,P; Chuang,DM. Valproic acid attenuates blood-brain       barrier disruption in a rat model of transient focal cerebral ischemia:the roles of HDAC       and MMP-9   inhibition. Journal Of Cerebral Blood FlowAnd Metabolism 2011 Jan;31      (1) :52-57

 

  • Yeh,SJ; Huang,KY; Wang,TG; Chen,YC; Chen,CH; Tang,SC; Tsai,LK; Yip,PK; Jeng,JS.   Dysphagia screening decreases pneumonia in acute stroke patients admitted to the stroke       intensive care unit. Journal Of The Neurological Sciences 2011  Jul 15;306 (1-2) :38-41

 

  • Yeh,SJ; Tsai,LK; Liu,HM; Yip,PK; Jeng,JS .Ischemic Stroke in Patients With Intracranial      Dural Arteriovenous   Fistulas. Journal Of The Formosan Medical Association 2011      May ;110 (5) :299-305

 

  • Koh E, Tsai LK (equal contribution), Hon CT. Serum calcium concentration affects signal changes on diffusion weighted imaging in hypoxic encephalopathy. AJNR Am. J. Neuroradiol. 2012;332:297-300.

 

  • Tsai LK, Chen YC, Cheng WC, Ting CH, Dodge JC, Hwu WL, Cheng SH, Passini MA. IGF-1 delivery to CNS attenuates motor neuron cell death but does not improve motor function in type III SMA mice. Neurobiol. Dis. 2012;451:272-279.

 

  • Chien YH, Peng SF, Yang CC, Lee NC, Tsai LK, et al. Long-term efficacy of miglustat in paediatric patients with Niemann-Pick disease type C. J. Inherit. Metab. Dis. 2012, Apr 5 online.

 

  • Tsai LK. Therapy development in spinal muscular atrophy with SMN independent target. Neural Plasticity 2012, ID 456478.

 

  • Wang Z, Tsai LK, Munasinghe J, Fessler E, Chibane F, Leeds P, Chunag DM. Valproate enhances post-ischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke. Stroke 2012 July 17 online.

 

  • Chen YW, Tang SC, Tsai LK, Yeh SJ, Chiou HY, Yip PK, Jeng JS*. Pre-ICH warfarin use, not antiplatelets, increased case fatality in spontaneous ICH patients. Eur. J. Neurol. 2012 Aug 17 online.

 

  • Tee BL, Tsai LK*, Lai CC, Tang SC, Chen YA, Chen CL, Jeng JS. The role of occipital artery in diagnosis of intracranial dural arteriovenous fistula using duplex sonography. AJNR Am. J. Neuroradiol. 2012 Sep 13 online.

 

  • Hsieh YC, Jeng JS, Lin HJ, et al, and the Formosa Stroke Genetic Consortium (Tsai LK, et al.). Epistasis analysis for estrogen metabolic and signaling pathway genes on young ischemic stroke patients. PloS One 2012;7:e47773.

 

  • Chen YW, Tang SC, Tsai LK, Yeh SJ, Chiou HY, Yip PK, Jeng JS*. Pre-ICH warfarin use, not antiplatelets, increased case fatality in spontaneous ICH patients. Eur. J. Neurol. 2013; AUG; 20 (8):1128-1134.
  • Liu HC, Ting CH, Wen HL, Tsai LK, Hsieh-Li HM, Li H, Lin-Chao S. Sodium vanadate combined with L-ascorbic acid delays disease progression, enhances motor performance, and ameliorates muscle atrophy and weakness in mice with spinal muscular atrophy. BMC Med. 2013; FEB; 11:38.

 

  • Chen NC, Hsieh MJ, Tang SC, Chiang WC, Huang KY, Tsai LK, Ko PCI, Ma MHM, Jeng JS. Factors associated with use of emergency medical services in patients with acute stroke. Am. J. Emerg. Med. 2013; MAY; 31 (5):788-791.

 

  • Tai YC, Tsai LK (corresponding author). Vascular territories of MCA branches by computerized tomography. Acta Neurol. Taiwan. 2013; MAR; 22 (1):49-50.

 

  • Wu MC, Tsai LK (corresponding author), Wu CC, et al. Thrombolytic therapy is an only determinant factor for stroke evolution in large anterior choroidal artery infarcts. J Strok Cerebrovasc Dis. 2013 OCT 14. doi:pii: S1052-3057(13)00389-3.

 

  • Chen CH, Tang SC, Tsai LK, et al. Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis. PlosOne, 2013;8:e80527.
  • Hsieh MJ, Tang SC, Chiang WC, Huang KY, Chang AM, Ko PC, Tsai LK, Jeng JS, Ma MH. Utilization of emergency medical service increases chance of thrombolytic therapy in patients with acute ischemic stroke. J. Formos. Med. Assoc. 2013; DEC; S0929-6646(13)00393-8.

 

  • Wu MC, Tsai LK*, Wu CC, et al. Thrombolytic therapy is an only determinant factor for stroke evolution in large anterior choroidal artery infarcts. J Strok Cerebrovasc Dis. 2014;23(5):1089-1093.

 

  • Li YC, Tsai LK, Wang JH, Young TH. A neural stem/precursor cell monolayer for neural tissue engineering. Biomaterials. 2014;35(4):1192-204.

 

  • Huang AP, Tsai JC, Kuo LT, Lee CW, Lai HS, Tsai LK, et al. Clinical application ofperfusion computed tomography in neurosurgery. J Neurosurg. 2014;120(2):473-88

 

  • Hsieh MJ, Tang SC, Chiang WC, Huang KY, Chang AM, Ko PC, Tsai LK, Jeng JS, Ma MH. Utilization of emergency medical service increases chance of thrombolytic therapy in patients with acute ischemic stroke. J Formos Med Assoc. 2014 Nov;113(11):813-819.

 

  • Yeh SJ, Tsai LK*, Tang SC, Jeng JS. Pin-point pupils with drowsiness as a presentation of Hashimoto's encephalopathy mimicking pontine infarction. Acta Neurol Taiwan. 2014;23(1):19-23.

 

  • Tsai LK*, Chen CL, Ting CH, Lin-Chao S, Hwu WL, Dodge JC, Passini MA, Cheng SH. Systemic administration of a recombinant AAV1 vector encoding IGF-1 improves disease manifestations in SMA mice. Mol Ther. 2014;22(8):1450-1459.
  • Lin SY, Tang SC, Tsai LK, Yeh SJ, Hsiao YJ, Chen YW, Chen KH, Yip BS, Shen LJ, Wu FL, Jeng JS. Orolingual angioedema after alteplase therapy of acute ischaemic stroke: incidence and risk of prior angiotensin-converting enzyme inhibitor use. Eur J Neurol. 2014;21(10) :1285-1291.

 

  • Tang SC, Yeh SJ, Tsai LK, Hu CJ, Lien LM, Peng GS, Yang WS, Chiou HY, Jeng JS. Association between plasma levels of hyaluronic acid and functional outcome in acute stroke patients. J Neuroinflammation. 2014;11:101.

 

  • Yeh SJ, Tang SC, Tsai LK, Jeng JS. Pathogenetical Subtypes of Recurrent Intracerebral Hemorrhage: Designations by SMASH-U Classification System. Stroke. 2014 Sep; 45(9):2636-2642.

 

  • Chen CH, Tang SC, Tsai LK, Hsieh MJ, Yeh SJ, Huang KY, Jeng JS. Stroke code improves intravenous thrombolysis administration in acute ischemic stroke. PLoS One. 2014;9(8):e104862.

 

  • Li YC, Tsai LK, Young TH. Intraventricular infusion of a low fraction of serum enhances neurogenesis and improves recovery in a rodent stroke model. Neuroscience Letter. 2016 Jan 12;611:14-20. doi: 10.1016/j.neulet.2015.11.020. Epub 2015 Nov 17.PMID: 26598023

 

  • Tsai LK, Chen CL, Tsai YC, Ting CH, Chien YH, Lee NC, Hwu WL. Hypothermia improves disease manifestations in SMA mice via SMN augmentation. Human Molecular Genetics. 2016 Feb 15;25(4):631-41.

 

  • Li YC, Wang JH, Tsai LK, Chen YA, Chang TC, Lou PJ, Young TH. 3,6-Bis(1-methyl-4-vinylpyridinium)-carbazole diiodide as a marker for tracking living neural stem/precursor cells. J. Mater. Chem. B 2015 Feb;3:2067-2074.

 

  • Tseng HP, Lin FJ, Chen PT, et al and Taiwan Stroke Registry Investigators (Tsai LK et al). Derivation and validation of a discharge disposition predicting model after acute stroke. J Stroke Cerebrovasc Dis. 2015 Jun;24(6):1179-86.

 

  • Tsai LK, Liu HH. Current treatment for generalized convulsive status epilepticus in adults. Acta Neurol Taiwan. 2015 Dec;24(4):108-115.

 

  • Lin SY, Tang SC, Tsai LK, Yeh SJ, Shen LJ, Wu FL, Jeng JS: Incidence and risk factors for acute kidney injury following mannitol infusion in patients with acute stroke: a retrospective cohort study. MEDICINE 2015 NOV;94:e2032.

 

  • Tsai HH, Tsai LK (co-corresponding author), Chen YF, Tang SC, Yen RF, Jeng JS. Correlation of cerebral microbleeds distribution to amyloid burden in patients with primary intracerebral hemorrhage. Scientific Report. 2017 Mar 17;7:44715.

 

  • Wang IK, Liu CH, Yen TH, et al; Taiwan Stroke Registry Investigators (Tsai LK, et al). Cholesterol levels are associated with 30-day mortality from ischemic stroke in dialysis patients. J Stroke Cerebrovasc Dis. 2017 Jun;26(6):1349-1356.Lee NC, Hwu WL, Muramatsu SI, Falk DJ, Byrne BJ, Cheng CH, Shih NC, Chang

 

  • KL, Tsai LK, Chien YH. A neuron-specific gene therapy relieves motor deficits in Pompe disease. Mol Neurobiol. 2017 Sep 11. doi: 10.1007/s12035-017-0763-4.

 

  • Charidimou A, Farid K, Tsai HH, Tsai LK, Yen RF, Baron JC. Amyloid-PET burden and regional distribution in cerebral amyloid angiopathy: a systematic review and meta-analysis of biomarker performance. J Neurol Neurosurg Psychiatry. 2017 Oct. pii: jnnp-2017-316851.48.

 

  • Tsai LK, Lin HJ, Chua SK, Liao PC, Yang YP, Chou PC, Lee CW, Lin MJ, Chen HM, Yeh JT, Li YH. Real-world experience with idarucizumab to reverse anticoagulant effect in dabigatran-treated patients: report of 11 cases from Taiwan. J Stroke Cerebrovasc Dis. 2017 Nov 6. pii: S1052-3057(17)30528-1.

 

  • Hsieh MJ, Chien KL, Sun JT, Tang SC, Tsai LK, Chiang WC, Chien YC, Jeng JS, Huei-Ming Ma M; Taipei EMS Stroke Collaborative Group. The effect and associated factors of dispatcher recognition of stroke: A retrospective observational study. J Formos Med Assoc. 2017 Nov 17. pii: S0929-6646(17)30650-2.

 

  • Yeh SJ, Tang SC, Tsai LK, Lee CW, Chen YF, Liu HM, Yang SH, Kuo MF, Jeng JS. Color Doppler ultrasonography as an alternative tool for postoperative evaluation of collaterals after indirect revascularization surgery in Moyamoya disease. PLoS One. 2017 Dec 8;12(12):e0188948. 

 

  • Wang IK, Liu CH, Yen TH, Jeng JS, Sung SF, Huang PH, Li JY, Sun Y, Wei CY, Lien LM, Tsai IJ, Sung FC, Hsu CY; Taiwan Stroke Registry Investigators (Jeng JS, Tang SC, Tsai LK, Yeh SJ, Chen CH, Tsai HH, et al). Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke. Atherosclerosis. 2017 Dec 11. pii: S0021-9150(17)31414-4. doi: 10.1016/j.atherosclerosis.2017.11.029. [Epub ahead of print]

 

趙啟超臨床教授(Chi-Chao Chao)

  •  Chao CC, Tseng MT, Lin YJ, Yang WS, Hsieh SC, Lin YH, Chiu MJ, Chang YC, Hsieh ST. Pathophysiology of neuropathic pain in type 2 diabetes: skin denervation and contact heat-evoked potentials. Diabetes Care. 2010;33:2654-9.

 

  • Yang NCC*, Lee MJ*, Chao CC*, Chuang YT, Lin WM, Chang MF, Hsieh PC, Kan HW, Lin YH, Yang CC, Chiu MJ, MD, Liou HH, Hsieh ST. Clinical presentations and skin denervation in amyloid neuropathy due to transthyretin Ala97Ser. Neurology. 2010;75:532-8. *: equal contribution

 

  • Lin MS, Chen YH, Chao CC, Lin CH, Li HY, Chao CL, Chen MF, Kao HL. Catheter-based neurosalvage for acute embolic complication during carotid intervention. J Vasc Surg. 2010;52:308-13.

 

  • Tan CH, Chen Y, Chen CC, Chao CC, Liou HH, Hsieh ST. Painful neuropathy due to skin denervation after metronidazole-induced neurotoxicity. J Neurol Neurosurg Psychiatry. 2011;82:462-5.

 

  • Tseng MT, Tseng WY, Chao CC, Lin HE, Hsieh ST. Distinct and shared cerebral activations in processing innocuous versus noxious contact heat revealed by functional magnetic resonance imaging.       Hum Brain Mapp. 2010;31:743-757.

 

  • Lin MS, Chiu MJ, Wu YW, Huang CC, Chao CC, Chen YH, Lin HJ, Li HY, Chen YF, Lin LC, Liu YB, Chao CL, Tseng WY, Chen MF, Kao HL. Neurocognitive improvement after carotid artery stenting in patients with chronic internal carotid artery occlusion and cerebral ischemia. Stroke. 2011;42:2850-4.

 

  • Luo KR, Chao CC, Chen YT, Huang CM, Yang NC, Kan HW, Wang SH, Yang WS, Hsieh ST. Quantitation of sudomotor innervation in skin biopsies of patients with diabetic neuropathy. J Neuropathol Exp Neurol. 2011;70:930-8.

 

  • Chao CC, Wu VC, Tan CH, Wang YM, Tseng MT, Wu PC, Lin YH, Lin WM, Wu KD, Hsieh ST. Skin denervation and its clinical significance in late-stage chronic kidney disease. Arch Neurol. 2011;68:200-6.

 

  • Tan CH, Chen Y, Chen CC, Chao CC, Liou HH, Hsieh ST. Painful neuropathy due to skin denervation after metronidazole-induced neurotoxicity. J Neurol Neurosurg Psychiatry. 2011;82:462-5.

 

  • Luo KR*, Chao CC*, Hsieh PC, Lue JH, Hsieh ST.  Effect of Glycemic Control on Sudomotor Denervation in Type 2 Diabetes. Diabetes Care. 2012;35:612-6 *: equal contribution

 

  • Chen YH, Lin MS, Lee JK, Chao CL, Tang SC, Chao CC, Chiu MJ, Wu YW, Chen YF, Shih TF, Kao HL. Carotid stenting improves cognitive function in asymptomatic cerebral ischemia. Int J Cardiol. 2012；157:104-7

 

  • Chao CC, Karabanov AN, Paine R, Carolina de Campos A, Kukke SN, Wu T, Wang H, Hallett M. Induction of Motor Associative Plasticity in the Posterior Parietal Cortex-Primary Motor Network. Cerebral Cortex (In Press)

 

  • Huang CC, Chen YH, Lin MS, Lin CH, Li HY, Chiu MJ, Chao CC, Wu YW, Chen YF, Lee JK, Wang MJ, Chen MF, Kao HL. Association of the recovery of objective abnormal cerebral perfusion with neurocognitive improvement after carotid revascularization. J Am Coll Cardiol. 2013 Jun 25;61:2503-9.
  • Karabanov AN, Chao CC, Paine R, Hallett M. Mapping different intra-hemispheric parietal-motor networks using twin coil TMS. Brain Stimul. 2013;6:384-9

 

  • Tseng MT, Chiang MC, Chao CC, Tseng WY, Hsieh ST.  fMRI evidence of degeneration-induced neuropathic pain in diabetes: Enhanced limbic and striatal activations. Hum Brain Mapp. 2013;34:2733-46

 

  • Kukke SN, Paine RW, Chao CC, de Campos AC, Hallett M. Efficient and reliable characterization of the corticospinal system using transcranial magnetic stimulation. J Clin Neurophysiol. 2014;31:246-52

 

  • Chao CC, Huang CM, Chiang HH, Luo KR, Kan HW, Yang NC-C, Chiang H, Lin WM, Lai SM, Lee MJ, Shun CT, Hsieh ST. Sudomotor innervation in transthyretin amyloid neuropathy: pathology and functional correlates. Ann Neurol 2015; 78:272-283.

 

  • Chiang MC, Tseng MT, Pan CL, Chao CC, Hsieh ST. Progress in the treatment of small fiber peripheral neuropathy. Expert Rev Neurother 2015; 9:1-9.

 

  • Hsieh PC, Tseng MT, Chao CC, Lin YH, Tseng WY, Liu KH, Chiang MC, Hsieh ST. Imaging signatures of altered brain responses in small-fiber neuropathy: reduced functional connectivity of the limbic system after peripheral nerve degeneration. Pain 2015; 156:904-916.

 

  • Tseng MT, Kong Y, Chiang MC, Chao CC, Tseng WY, Hsieh ST. Brain imaging signatures of the relationship between epidermal nerve fibers and heat pain perception. NeuroImage 2015; 122:288-297.

 

  • Lai HJ, Chiang YW, Yang CC, Hsieh ST, Chao CC, Lee MJ, Kuo CC. The Temporal Profiles of Changes in Nerve Excitability Indices in Familial Amyloid Polyneuropathy. PLoS One. 2015;10(11):e0141935

 

  • Lin MT, Lee LJ, Chao CC, Hsieh ST. Quality of life in polyneuropathy: association with biomarkers of small fiber impairment. Health Qual Life Outcomes. 2015;13(1):169. (Corresponding)

 

  • Jiang HC, Hsu JM, Yen CP, Chao CC, Chen RH, Pan CL. Neural activity and CaMKII protect mitochondria from fragmentation in aging Caenorhabditis elegans neurons. Proc Natl Acad Sci. 2015;112(28):8768-73.

 

  • Tsai HH, Chen YF, Hsieh ST, Chao CC. Neurolymphomatosis as the primary presentation of non-Hodgkin's Lymphoma. J Neurol Neurosurg Psychiatry 2015;86(8):929-30. (Corresponding)

 

  • Karabanov AN, Paine R, Chao CC, Schulze K, Scott B, Hallett M, Mishkin M. Participation of the classical speech areas in auditory long-term memory. PLoS One. 2015;10(3):e0119472.

 

  • Chao CC, Karabanov AN, Paine R, Carolina de Campos A, Kukke SN, Wu T, Wang H, Hallett M. Induction of Motor Associative Plasticity in the Posterior Parietal Cortex-Primary Motor Network. Cerebral Cortex 2015;25(2):365-73

 

林靜嫻臨床教授(Chin-Hsien Lin)

  • Lee MJ, Mata IF, Lin CH, Tzen KY, Lincoln SJ, Bounds R, Lockhart  PJ, Hulihan MM, Farrer MJ, Wu RM. Genotype-Phenotype correlates in  Taiwanese patients with early-onset recessive parkinsonism. Mov  Disord. 2009; 15;24(1):104-8. (SCI)

 

  • Tai CH, Yen RF, Lin CH, Yen KY, Yip PK, Wu RM, Lee MJ. Focal brain  glucose hypermetabolism in myoclonus-dystonia syndrome caused by an epsilon-sarcoglycan gene mutation. Parkinsonism Relat Disord.  2009;15(8):614-6 (SCI)

 

  • Ross OA, Spanaki C, Griffith A, Lin CH, Kachergus J, Haugarvoll K,  Latsoudis H, Plaitakis A, Ferreira JJ, Sampaio C, Bonifati V, Wu RM,  Zabetian CP, Farrer MJ. Haplotype analysis of Lrrk2 R1441H carriers  with parkinsonism. Parkinsonism and Related Disorders.  2009;15(6):466-7. (SCI)

 

  • Taylor JM, Wu RM, Lin CH, Delatycki MB, Lockhart PJ. Lack of  evidence for association of a parkin promoter polymorphism with  early-onset Parkinson's disease in a Chinese population. Parkinsonism  and Related Disorders. 2009;15(2):149-52. (SCI)

 

  • Eng-King Tan, Chin-Hslen Lin, Chun-Hwei Tai, Louis C. Tan,  Meng-Ling Chen, R. Li, Hui-Qin Lim, Ratnagopal Pavanni, Yih Yuen, K.  M. Prakash, Yi Zhao, Ruey-Meei Wu. Non-synonymous GIGYF2 variants in  Parkinson's disease from two Asian populations. Hum Genet. 2009 May  16. [Epub ahead of print] (SCI)

 

  • Hoi-Fong Chan, Meng-Ling Chen, Jen-Jen Su, Li-Chin Ko, Chin-Hsien  Lin*(corresponding author), Ruey-Meei Wu. A novel neuropsychiatric  phenotype of KCNJ2 mutation in one Taiwanese family with  Andersen-Tawil syndrome. J Hum Genetics 2010 Mar;55(3):186-8. (SCI)

 

  • Tai CH, Wu RM, Lin CH, Pan MK, Chen YF, Liu HM, Lu HH, Tsai CW,  Tseng SH. Deep brain stimulation therapy for parkinson's disease using  frameless stereotaxy: comparison with frame-based surgery. Eur J  Neurol. 2010 Apr 23. [Epub ahead of print] PMID: 20443976 [PubMed - as  supplied by publisher] (SCI)

 

  • Tan EK, Peng R, Teo YY, Tan LC, Angeles D, Ho P, Chen ML, Lin CH,  Mao XY, Chang XL, Prakash KM, Liu JJ, Au WL, Le WD, Jankovic J,  Burgunder JM, Zhao Y, Wu RM. Multiple LRRK2 variants modulate risk of  Parkinson disease: a Chinese multicenter study. Hum Mutat. 2010  May;31(5):561-8. (SCI)

 

  • Yu RL, Wu RM, Tai CH, Lin CH, Hua MS. Feeling-of-knowing in  episodic memory in patients with Parkinson's disease with various  motor symptoms. Mov Disord. 2010;25(8):1034-9. (SCI)

 

  • Chin-Hsien Lin, Pei-I Tsai, Ruey-Meei Wu, Cheng-Ting Chien. LRRK2  G2019S Mutation Induces Dendrite Degeneration through Mislocalization  and Phosphorylation of Tau by Recruiting Autoactivated GSK3. J  Neurosci 2010;30(39):13138-49. (SCI)

 

  • Yu-Ren Chen, Ya-Ping Huang, Shan-Ju, Lin, Tsao-Hsiang Kuan,  Chin-Hsien Lin* (corresponding author). Effectiveness of Quetiapine  for Post-Stroke Pathological Laughing: Case Report and Review of the  Literature. Clinical Neuropharmacology 2010 Nov-Dec;33(6):319-22.

 

  • Huang,SL; Hsieh,CL; Wu,RM; Tai,CH; Lin,CH; Lu,WS . Minimal Detectable Change of       the Timed ""Up & Go"" Test and the Dynamic Gait Index in People With Parkinson      Disease. Pysical Therapy 2011  JAN;91 (1) :114-121

13. Lin,CH; Chen,ML; Chen,GS; Tai,CH; Wu,RM. Novel variant Pro143Ala in HTRA2  contributes to Parkinson's disease by inducing  hyperphosphorylation of HTRA2 protein in mitochondria. Human Genetics 2011 Dec;130 (6) :817-827

14. Lin,CH; Wu,RM; Tai,CH; Chen,ML; Hu,FC . Lrrk2 S1647T and BDNF V66M interact  with environmental factors to  increase risk of Parkinson's disease. Parkinsonism & Related      Disorders,2011 Feb;17 (2) :84-88

  • Ross,OA; Soto-tolaza,AI; Heckman,MG; Aasly,JO; Abahuni,N; Annesi,G; Bacon,JA;       Bardien,S; Bozi,M; Brice,A; Brighina,L; VanBroeckhoven,C;Carr,J; Chartier-Harlin,MC;       Dardiotis,E; Dickson,DW; Diehl,NN; Elbaz,A; Ferrarese,C; Ferraris,A; Fiske,B;       Gibson,JM; Gibson,R; Hadjigeorgiou,GM; Hattori,N;Ioannidis,JPA; Jasinska-Myga,B;       Jeon,BS; Kim,YJ; Klein,C; Kruger,R; Kyratzi,E;Lesage,S; Lin,CH; Lynch,T;       Maraganore,DM; Mellick,GD; Mutez,E; Nilsson,C;Opala,G; Park,SS; Puschmann,A;       Quattrone,A; Sharma,M; Silburn,PA; Sohn,YH;Stefanis,L; Tadic,V; Theuns,J;       Tomiyama,H; Uitti,RJ; Valente,EM; vandeLoo,S;Vassilatis,DK; Vilarino-Guell,C;       White,LR; Wirdefeldt,K; Wszolek,ZK; Wu,RM; Farrer,MJ . Association of LRRK2 exonic variants with susceptibility to Parkinson's   disease: a case-control study. Lancet Neurology 2011 Oct;10 (10) :898-908

 

  • Yen,CY; Lin,KH; Hu,MH; Wu,RM; Lu,TW; Lin,CH .Effects of Virtual eality-Augmented       Balance Training on Sensory Organization and Attentional Demand for Postural Control in  People With Parkinson Disease: A Randomized Controlled Trial. Physical Therapy 2011   Jun;91 (6) :862-874

 

  • Kai-Hsiang Chen, Chin-Hsien Lin*(corresponding author), Ruey-Meei Wu.  Psychotic-Affective Symptoms and Multiple System Atrophy Expand Phenotypes of  Spinocerebellar Ataxia Type 2. BMJ Case Reports 2012, Mar 20; in press. 

 

  • Rwei-Ling Yu, Ruey-Meei Wu, Chun-Hwei Tai, Chin-Hsien Lin, Ting-Wen Cheng,  Mau-Sun Hua* Neuropsychological profile in patients with early stage of Parkinson's disease in Taiwan. Parkinsonism Relat Disord. 2012, Jun 30; in press.

 

  • Meng-Chen Wu, Ruoh-Fang Yen, Chin-Hsien Lin*(corresponding author),  Ruey-Meei Wu. Hemiballism in a Patient with Parietal Lobe Infarction. Neurology,  2012, in press.

 

  • Yu RL, Wu RM, Chiu MJ, Tai CH, Lin CH, Hua MS. Advanced Theory of Mind in patients at early stage of Parkinson's disease.Parkinsonism Relat Disord.2012;18(1):21-4.

 

  • Chen KH, Lin CH*, Wu RM. Psychotic-affective symptoms and multiple system atrophy expand phenotypes of spinocerebellar ataxia type 2.BMJ Case Rep. 2012 Mar 20;doi:pii: bcr1020115061.

 

  • Yu RL, Wu RM, Tai CH, Lin CH, Cheng TW, Hua MS. Neuropsychological profile in patients with early stage of Parkinson's disease in Taiwan. Parkinsonism Relat Disord.2012;18(10):1067-72.

 

  • Lai HJ, Lin CH*, Wu RM. Early-onset autosomal-recessive parkinsonian-pyramidal syndrome. Acta Neurol Taiwan. 2012 Sep;21(3):99-107.

 

  • 65.Lin CH, Chen ML, Tai YC, Yu CY, Wu RM. Reaffirmation of GAK, but not HLA-DRA, as a Parkinson's disease susceptibility gene in a Taiwanese population. Am J Med Genet B Neuropsychiatr Genet. 2013 Sep 3. doi: 10.1002/ajmg.b.32188. [Epub ahead of print]

 

  • Lee YC※, Lin CH※(co-first author), Wu RM, Lin MS, Lin JW, Chang CH, Lai MS.Discontinuation of statin therapy associates with Parkinson disease: a population-based study. Neurology. 2013 Jul 30;81(5):410-6. 

 

  • Lin CH, Wu RM, Chang HY, Chiang YT, Lin HH. Preceding pain symptoms and Parkinson's disease: a nationwide population-based cohort study. Eur J Neurol. 2013 Oct;20(10):1398-404. 

 

  • Lin CH, Chen ML, Yu CY, Wu RM.RIT2 variant is not associated with Parkinson's disease in a Taiwanese population. Neurobiol Aging. 2013 Sep;34(9):2236.e1-3. 

 

  • Lin CH, Wu VC, Li WY, Sy HN, Wu SL, Chang CC, Chiu PF, Lion HH, Lin CY, Chang HW, Lin SY, Wu KD, Chen YM, Wu RM. Restless legs syndrome in end-stage renal disease: a multicenter study in Taiwan. Eur J Neurol. 2013 Jul;20(7):1025-31. 

 

  • Lin CH, Chen ML, Lai TT, Tai CH, Wu RM. Mutational analysis of FBXO7 gene in Parkinson's disease in a Taiwanese population. Neurobiol Aging. 2013 Jun;34(6):1713.e1-4. 

 

  • Wu MC, Yen RF, Lin CH (corresponding author), Wu RM. Hemiballism in a patient with parietal lobe infarction. Neurology. 2013 Jan 15;80(3):e22. 

 

  • Lin CH, Ou YK, Wu RM, Liu YC. Predictors of road crossing safety in pedestrians with Parkinson's disease. Accid Anal Prev. 2013 Mar;51:202-7. 

 

  • Chen ML, Lin CH, Lee MJ, Wu RM. BST1 rs11724635 interacts with environmental factors to increase the risk of Parkinson's disease in a Taiwanese population. Parkinsonism Relat Disord. 2013 Nov 20. pii: S1353-8020(13)00402-1. doi: 10.1016/j.parkreldis.2013.11.009. [Epub ahead of print]

 

  • Heckman MG, Soto-Ortolaza AI, Aasly JO, Abahuni N, Annesi G, Bacon JA, Bardien S, Bozi M, Brice A, Brighina L, Carr J, Chartier-Harlin MC, Dardiotis E, Dickson DW, Diehl NN, Elbaz A, Ferrarese C, Fiske B, Gibson JM, Gibson R, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Boczarska-Jedynak M, Jasinska-Myga B, Jeon BS, Kim YJ, Klein C, Kruger R, Kyratzi E, Lesage S, Lin CH, Lynch T, Maraganore DM, Mellick GD, Mutez E, Nilsson C, Opala G, Park SS, Petrucci S, Puschmann A, Quattrone A, Sharma M, Silburn PA, Sohn YH, Stefanis L, Tadic V, Theuns J, Tomiyama H, Uitti RJ, Valente EM, Van Broeckhoven C, van de Loo S, Vassilatis DK, Vilariño-Güell C, White LR, Wirdefeldt K, Wszolek ZK, Wu RM, Hentati F, Farrer MJ, Ross OA; Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium. Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium. Mov Disord. 2013 Oct;28(12):1740-4. doi: 10.1002/mds.25600. Epub 2013 Aug 2.

 

  • Lee YC※, Lin CH※(co-first author), Lin MS, Lin JW, Chang CH, Lai MS. Effects of selective serotonin reuptake inhibitors versus tricyclic antidepressants on cerebrovascular events: a nationwide population-based cohort study. J Clin Psychopharmacol. 2013 Dec;33(6):782-9. 

 

  • Chen KH, Lin CH(corresponding author). Brain abscess as an initial presentation in a patient of hereditary haemorrhagic telangiectasia caused by a novel ENG mutation. BMJ Case Rep. 2013 Feb 25;2013. pii: bcr2013008802. doi: 10.1136/bcr-2013-008802.

 

  • Liu WM, Lin CH(corresponding author). A reversible stroke-like splenial lesion in viral encephalopathy. Acta Neurol Taiwan. 2013 Sep;22(3):117-21.

 

  • Michael G. Heckman, Alexis Elbaz, Alexandra I. Soto-Ortolaza, Daniel J. Serie, Jan O. Aasly, Grazia Annesi, Georg Auburger, Justin A. Bacon, Magdalena Boczarska-Jedynak, Maria Bozi, Laura Brighina, Marie-Christine Chartier-Harlin, Efthimios Dardiotis, Alain Destée, Carlo Ferrarese, Alessandro Ferraris, Brian Fiske, Suzana Gispert, Georgios M. Hadjigeorgiou, Nobutaka Hattori, John P. A. Ioannidis, Barbara Jasinska-Myga, Beom S. Jeon, Yun Joong Kim, Christine Klein, Rejko Kruger, Elli Kyratzi, Chin-Hsien Lin, Katja Lohmann, Marie-Anne Loriot PharmD, Timothy Lynch, George D. Mellick, Eugénie Mutez, Grzegorz Opala, Sung Sup Park, Simona Petrucci, Aldo Quattrone, Manu Sharma, Peter A. Silburn, Young Ho Sohn, Leonidas Stefanis, Vera Tadic, Hiroyuki Tomiyama, Ryan J. Uitti, Enza Maria Valente, Demetrios K. Vassilatis, Carles Vilariño-Güell, Linda R. White, Karin Wirdefeldt, Zbigniew K. Wszolek, Ruey-Meei Wu, Georgia Xiromerisiou, Demetrius M. Maraganore, Matthew J. Farrer, Owen A. Ross* on behalf of the Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium. The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants. Neurobiology of Aging 2014 Jan;35(1):266.e5-266.

 

  • Chin-Hsien Lin, Kai-Hsiang Chen, Meng-Ling Chen, Han-I Lin, Ruey-Meei Wu. Vitamin D receptor genetic variants and Parkinson's disease in a Taiwanese population. Neurobiology of Aging 2014 May;35(5):1212.e11-3

 

  • Chin-Hsien Lin, Meng-Ling Chen, Vin-Cent Wu, Wen-Yi Li, Hiu-Ngar Sy, Shey-Lin Wu; Chia-Chu Chang, Ping-Fang Chiu, Hung-Hsiang Liou, Chien-Yu Lin, Hong-Wei Chang, Sen-Yong Lin, Kwan-Dun Wu, Yung-Ming Chen, Ruey-Meei Wu. Association of candidate genetic variants with restless legs syndrome in end stage renal disease: a multicenter case-control study in Taiwan. European Journal of Neurology 2014 Mar;21(3):492-8.

 

  • Chin-Hsien Lin, Han-I Lin, Ruey-Meei Wu. The p.L302P mutation of lysosomal enzyme gene SMPD1 is rare in Taiwanese Parkinson's disease. Neurology. 2014 Jan 21;82(3):283.

 

  • Chin-Hsien Lin, Ta-Fu Chen, Ming-Jang Chiu, Ruey-Meei Wu. Lack of C9orf72 repeat expansion in Taiwanese patients with mixed neurodegeneratiave disorders. Frontiers in Neurology 2014 Apr 28;5:59.

 

  • Yu-Wen Cheng, Chin-Hsien Lin*, Ruey-Meei Wu. HIV-associated Parkinsonism Reversed with Antiretroviral Therapy. Neurology Asia 2014, accepted.

 

  • Meng-Chen Wu, Chin-Hsien Lin*. Cauda Equina-Conus Medullaris Syndrome as an Isolated Presenting Symptom of Intravascular Large B-cell Lymphoma: Case Report and Review of the Literature. Neurology Asia 2014, accepted.

 

  • Yen-Chieh Lee, Chin-Hsien Lin (co-first author), Ruey-Meei Wu, Jou-Wei Lin, Chia-Hsuin Chang, Mei-Shu Lai. Antihypertensive Agents and Risk of Parkinson's disease: A nationwide cohort study. PLOS One 2014 Jun 9;9(6):e98961

 

  • Chang CH, Lin JW, Lin CH, Chen HC, Hwang JJ, Lai MS. Effectiveness and safety of extracranial carotid stent placement: A nationwide self-controlled case-series study. J Formos Med Assoc 2014 Jun 10. pii: S0929-6646(14)00153-3.

 

  • Chin-Hsien Lin, Hiu-Ngar Sy, Hong-Wei Chang, Hung-Hsiang Liou, Chien-Yu Lin, Vin-Cent Wu, Shey-Lin Wu, Chia-Chu Chang, Ping-Fang Chiu, Wen-Yi Li, Sen-Yong Lin, Kwan-Dun Wu, Yung-Ming Chen, Ruey-Meei Wu. Restless legs syndrome is associated with cardio/cerebrovascular events and mortality in end-stage renal disease. European Journal of Neurology 2014 Aug 21. doi: 10.1111/ene.12545.

 

  • Chin-Hsien Lin, Hang-I Lin, Meng-Ling Chen, Ruey-Meei Wu. COQ2 p.V393A variant, rs148156462, is not associated with Parkinson's disease in a Taiwanese population. Neurobiology of Aging 2014 Aug 13. pii: S0197-4580(14)00519-3. doi:

 

  • Chin-Hsien Lin, Jou-Wei Lin, Ying-Chun Liu, Chia-Hsuin Chang, Ruey-Meei Wu. Risk of Parkinson's disease after severe constipation: a nationwide population-based cohort study. Parkinsonism & Related Disorders 2014 Sep 28. pii: S1353-8020(14)00363-0. doi: 10.1016/j.parkreldis.2014.09.026

 

  • Chen ML, Wu RM, Tai CH, Lin CH*(corresponding author).Mutational analysis of angiogenin gene in Parkinson's disease. PLoS One 2014 Nov 11;9(11):e112661.

 

  • Chin-Hsien Lin, Hiu-Ngar Sy, Hong-Wei Chang, Hung-Hsiang Liou, Chien-Yu Lin, Vin-Cent Wu, Shey-Lin Wu, Chia-Chu Chang, Ping-Fang Chiu, Wen-Yi Li, Sen-Yong Lin, Kwan-Dun Wu, Yung-Ming Chen, Ruey-Meei Wu. Restless legs syndrome is associated with cardio/cerebrovascular events and mortality in end-stage renal disease. European Journal of Neurology 2015 Jan;22(1):142-9.

 

  • Chin-Hsien Lin, Hang-I Lin, Meng-Ling Chen, Ruey-Meei Wu. COQ2 p.V393A variant, rs148156462, is not associated with Parkinson's disease in a Taiwanese population. Neurobiology of Aging 2015 Jan;36(1):546.e17-8.

 

  • Chin-Hsien Lin, Eng-King Tan, Chih-Chao Yang, Zhao Yi, Ruey-Meei Wu. COQ2 gene variants associate with cerebellar subtype of multiple system atrophy in Chinese. Movement Disorders 2015 Mar;30(3):436-7. 

 

  • Lin CH, Wu RM. Biomarkers of cognitive decline in Parkinson's disease. Parkinsonism & Related Disorder 2015 May;21(5):431-43.

 

  • Chin-Hsien Lin, Hsun Li, Yi-Nan Lee, Ying-Ju Cheng, Ruey-Meei Wu, Cheng-Ting Chien. Lrrk regulates the dynamic profile of dendritic Golgi outposts through the golgin Lava lamp. Journal of Cell Biology 2015 Aug 3;210(3):471-83. 

 

  • Chin-Hsien Lin, Jou-Wei Lin, Ying-Chun Liu, Chia-Hsuin Chang, Ruey-Meei Wu. Risk of Parkinson's disease following anxiety disorders: A nationwide population-based cohort study. European Journal of Neurology 2015 Sep;22(9):1280-7. 

 

  • Weng-Ming Liu, Ruey-Meei Wu, Jou-Wei Lin, Chia-Hsuin Chang, Chin-Hsien Lin* Time trends in the prevalence and incidence of Parkinson's disease in Taiwan: A nationwide, population-based study. Journal of the Formosan Medical Association 2015 Jun 26. pii: S0929-6646(15)00184-9. 

 

  • Chang CH, Lin CH, Caffrey JL, Lee YC, Liu YC, Lin JW, Lai MS. Risk of Intracranial Hemorrhage from Statin Use in Asians: A Nationwide Cohort Study. Circulation. 2015 Jun 9;131(23):2070-8. 

 

  • Kai-Hsiang Chen, Ruey-Meei Wu, Hang-I Lin,Chun-Hwei Tai, Chin-Hsien Lin* Mutational analysis of SYNJ1 gene (PARK20) in Parkinson's disease in a Taiwanese population. Neurobiology of Aging 2015 Oct;36(10):2905.e7-8. 

 

 

  • Liu WM, Lin RJ, Yu RL, Tai CH, Lin CH, Wu RM. The impact of nonmotor symptoms on quality of life in patients with Parkinson's disease in Taiwan. Neuropsychiatr Dis Treat. 2015 Nov 11;11:2865-73.

 

 

  • Gustavsson EK, Trinh J, Guella I, Szu-Tu C, Khinda J, Lin CH, Wu RM, Stoessl J, Appel-Cresswell S, McKeown M, Rajput A, Rajput AH, Petersen MS, Jeon BS, Aasly JO and Farrer MJ. DCTN1 p.K56R in progressive supranuclear palsy. Parkinsonism Relat Disord. 2016;28:56-61.

 

  • Liu WM, Wu RM, Lin JW, Liu YC, Chang CH and Lin CH. Time trends in the prevalence and incidence of Parkinson's disease in Taiwan: A nationwide, population-based study. J Formos Med Assoc. 2016;115:531-8.

 

 

  • Hsien-Han Lin, Ruey-Meei Wu, Han-I Lin, Meng-Ling Chen, Chun-Hwei Tai, Chin-Hsien Lin*. Lack of RAB39B mutations in early-onset and familial Parkinson's disease in a Taiwanese cohort. Neurobiology of Aging 2017 Feb;50:169.e3-169.

 

  • Sung-Ju Hsueh, Ni-Chung Lee, Shu-Hua Yang, Han-I Lin, Chin-Hsien Lin*. A limb-girdle myopathy phenotype of RUNX2 mutation in a patient with cleidocranial dysplasia: a case study and literature review. BMC Neurology 2017 Jan 6;17(1):2. doi: 10.1186/s12883-016-0781-2.

 

  • Song L, He Y, Ou J, Zhao Y, Li R, Cheng J, Lin CH, Ho MS. Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson's Disease. Cell Rep. 2017 Jan 31;18(5):1132-1143.

 

  • Chin-Hsien Lin, Shieh-Yueh Yang, Herng-Er Horng, Che-Chuan Yang, Jen-Jie Chieh, Hsin-Hsien Chen, Bing-Hsien Liu, Ming-Jang Chiu. Plasma α-synuclein predicts cognitive decline in Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry 2017 Oct;88(10):818-824.

 

  • Ming-Tsung Tseng, Chin-Hsien Lin*. Pain in early-stage Parkinson's disease: implications from clinical features to pathophysiology mechanisms. Journal of the Formosan Medical Association 2017 Aug;116(8):571-581.

 

  • Chin-Hsien Lin, K. Ray Chaudhuri, Jun-Yu Fan, Chia-I Ko, Alexandra Rizos, Chia-Wen Chang, Han-I Lin, and Yih-Ru Wu. Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson's disease. Scientific Reports 2017 Jul 24;7(1):6306. doi: 10.1038/s41598-017-06782-z.

 

  • Tian-Sin Fan, Chin-Hsien Lin*, Hang-I Lin, Meng-Ling Chen, Ruey-Meei Wu. Lack of TMEM230 mutations in patients with familial and sporadic Parkinson's disease in a Taiwanese population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2017 Oct;174(7):751-756

 

  • Shieh-Yueh Yang*, Ming-Jang Chiu, Ta-Fu Chen, Chin-Hsien Lin, Jiann-Shing.

 

  • Jeng, Sung-Chun Tang, Yen-Fu Lee, Che-Chuan Yang, Bing-Hsien Liu, Hsin-Hsien Chen, and Chau-Chung Wu. Analytical performance of reagent for assaying tau protein in human plasma and feasibility study screening neurodegenerative diseases. Scientific Reports 2017 Aug 24;7(1):9304. doi: 10.1038/s41598-017-09009-3.

 

  • Hui-Chi Lin, Chin-Hsien Lin, Pei-Lung Chen, Shih-Jung Cheng; Pei-Hao Chen. Intrafamilial phenotypic heterogeneity in a Taiwanese family with MAPT p.R5H mutation: a case report and literature review. BMC Neurology 2017 Sep 18;17(1):186. doi: 10.1186/s12883-017-0966-3.

 

  • Ying-Fa Chen; Yung-Yee Chang; Min-Yu Lan; Pei-Lung Chen, Chin-Hsien Lin*. Identification of VPS35 p.D620N mutation-related Parkinson's disease in a Taiwanese family with successful bilateral subthalamic nucleus deep brain stimulation: a case report and literature review. BMC Neurology 2017 Oct 6;17(1):191. doi: 10.1186/s12883-017-0972-5.Chin-Hsien Lin, Yu-Che Cheng, Han-I Lin, Ming-Ching Ho, Yu-Hung Hsu, Cheng-Hao Wen, Hui-Wen Ko, Huai-En Lu, Ching-Ying Huang*, Patrick C.H. Hsieh*. Generation of induced pluripotent stem cells from a patient with Parkinson's disease carrying LRRK2 p.I2012T mutation. Stem Cell Research 2017 Oct 31;25:123-127.

 

湯頌君臨床教授(Sung-Chun Tang. Tang SC)

  • Jeng JS, Tang SC, Deng IC, Tsai LK, Yeh SJ, Yip PK. Stroke center characteristics which influence the administration of thrombolytic therapy for acute ischemic stroke: a national survey of stroke centers in Taiwan. J Neurol Sci. 2009 Jun 15;281(1-2):24-7. Epub 2009 Apr 10.

 

  • Tang SC, Jeng JS, Lee MJ, Yip PK. Notch signaling and CADASIL. Acta Neurol Taiwan. 2009 Jun;18(2):81-90. Review. 

 

  • Tang SC, Jeng JS. Management of stroke in pregnancy and the puerperium. Expert Rev Neurother. 2010 Feb;10(2):205-15. Review

 

  • Cheng MF, Wu YW, Tang SC. Cerebral perfusion changes in hemiplegic migraine: illustrated by Tc-99m ECD brain perfusion scan. Clin Nucl Med. 2010 Jun;35(6):456-8 (correspondence).

 

  • Arumugam,TV; Cheng,YL; Choi,Y; Choi,YH; Yang,S; Yun,YK; Park,JS; Yang,DK;      Thundyil,J; Gelderblom,M; Karamyan,VT; Tang,SC; Chan,SL; Magnus,T; Sobey,CG;       Jo,DG.  Evidence That Gamma-Secretase-Mediated Notch Signaling Induces Neuronal       Cell Death Via The Nuclear Factor-Kappa B-Bcl-2-Interacting Mediator Of  Cell Death      Pathway In Ischemic Stroke.Molecular Pharmacology 2011 JUL;80 (1) 23-31.

 

  •  Tang,SC; Lee,CF; Lee,CW; Jeng,JS. Systemic lupus erythematosus flare up manifestation      as cerebral and spinal subarachnoid hemorrhage. Lupus 2011Oct;20 (11) :1211-1213

 

  • Tang,SC; Hu,CJ; Chiou,HY; Jeng,JS . Elevated Plasma Levels of Soluble Form of RAGE       and High Mobility Group   Box 1 in Patients with Acute Stroke.STROKE 2011 MAR;42      (3) :E203-E204

 

  • Woodruff,Tm; Thundyil,J; Tang,SC; Sobey,CG; Taylor,SM; Arumugam,TV.      Pathophysiology, treatment, and animal and cellular models of human ischemic stroke.  Molecular Neurodegeneration 2011  JAN25;6

 

  • Yeh,SJ; Huang,KY; Wang,TG; Chen,YC; Chen,CH; Tang,SC; Tsai,LK; Yip,PK; Jeng,JS. Dysphagia screening decreases pneumonia in acute stroke patients admitted to the stroke        intensive care unit. Journal Of The Neurological Sciences 2011  Jul 15;306 (1-2) :38-41

 

  • Hsieh YC, Seshadri S, Chung WT, Hsieh FI, Hsu YH, Lin HJ, Tseng HP, Lien LM, Bai CH, Hu CJ, Jeng JS, Tang SC, Chen CI, Yu CC, Chiou HY; the Formosa Stroke Genetic Consortium (FSGC). Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan.  Journal of Biomedical Science. 2012 Jan 3;19(1):1. (SCI)

 

  • Chen KS, Chou CC, Tang SC, Jeng JS. (correspondence). Distinguishing Critical Stenosis from Occlusion of the Internal Carotid Artery by Carotid Duplex in a Patient with Acute Ischemic Stroke. Journal of Medical Ultrasound. 2012 Mar 20 (1): 58-60.

 

  • Hsieh YC, Jeng JS, Lin HJ, Hu CJ, Yu CC, Lien LM, Peng GS, Chen CI, Tang SC, Chi NF, Tseng HP, Chern CM, Hsieh FI, Bai CH, Chen YR, Chiou HY; Formosa Stroke Genetic Consortium (FSGC)..  Epistasis analysis for estrogen metabolic and signaling pathway genes on young ischemic stroke patients. PLoS One. 2012;7(10):e47773

 

  • Tee BL, Tsai LK, Lai CC, Tang SC, Chen YA, Chen CL, Jeng JS.  The Role of the Occipital Artery in the Diagnosis of Intracranial Dural Arteriovenous Fistula Using Duplex Sonography. American Journal of Neuroradiology. 2012 Sep 13

 

  • Chen YW, Tang SC, Tsai LK, Yeh SJ, Chiou HY, Yip PK, Jeng JS. Pre-ICH warfarin use, not antiplatelets, increased case fatality in spontaneous ICH patients. European Journal of Neurology. 2012 Aug 17

 

  • Gwon AR, Park JS, Arumugam TV, Kwon YK, Chan SL, Kim SH, Baik SH, Yang S, Yun YK, Choi Y, Kim S, Tang SC, Hyun DH, Cheng A, Dann CE 3rd, Bernier M, Lee J, Markesbery WR, Mattson MP, Jo DG.  Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease. Aging Cell. 2012 Aug;11(4):559-68

 

  • Widiapradja A, Vegh V, Lok KZ, Manzanero S, Thundyil J, Gelderblom M, Cheng YL, Pavlovski D, Tang SC, Jo DG, Magnus T, Chan SL, Sobey CG, Reutens D, Basta M, Mattson MP, Arumugam TV.  Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways. Journal of Neurochemistry. 2012 Apr 12.

 

  • Broughton BR, Brait VH, Guida E, Lee S, Arumugam TV, Gardiner-Mann CV, Miller AA, Tang SC, Drummond GR, Sobey CG. Stroke Increases G Protein-Coupled Estrogen Receptor Expression in the Brain of Male but Not Female Mice.Neurosignals. 2012 Aug 1

 

  • Park JS, Manzanero S, Chang JW, Choi Y, Baik SH, Cheng YL, Li YI, Gwon AR, Woo HN, Jang J, Choi IY, Lee JY, Jung YK, Tang SC, Sobey CG, Arumugam TV, Jo DG. Calsenilin contributes to neuronal cell death in ischemic stroke. Brain Pathology. 2012 Dec 4.

 

  • Chen YH, Lin MS, Lee JK, Chao CL, Tang SC, Chao CC, Chiu MJ, Wu YW, Chen YF, Shih TF, Kao HL. Carotid stenting improves cognitive function in asymptomatic cerebral ischemia. International Journal of Cardiology. 2012 May 17;157(1):104-7.

 

  • Hsieh MJ*, Tang SC*, Chiang WC, Huang KY, Chang AM, Ko PC, Tsai LK, Jeng JS, Ma MH. Utilization of emergency medical service increases chance of thrombolytic therapy in patients with acute ischemic stroke. J Formos Med Assoc. 2013 Dec 2. (*equal first author)

 

  • Chen CH*, Tang SC *, Tsai LK, Yeh SJ, Chen KH, Li CH, Hsiao YJ, Chen YW, Yip BS, Jeng JS. Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis. PLoS One. 2013 Nov22;8(11):e80527. (*equal first author)

 

  • Tang SC, Yeh SJ, Li YI, Wang YC, Baik SH, Santro T, Widiapradja A, ManzaneroS, Sobey CG, Jo DG, Arumugam TV, Jeng JS. Evidence for a detrimental role of TLR8 in ischemic stroke. Exp Neurol. 2013 Dec;250

 

  • Wu MC, Tsai LK, Wu CC, Yeh SJ, Tang SC, Chen YJ, Chen CL, Jeng JS.Thrombolytic Therapy Is an Only Determinant Factor for Stroke Evolution in Large Anterior Choroidal Artery Infarcts. J Stroke Cerebrovasc Dis. 2013 Oct 14

 

  • Tang SC, Lin RJ, Shieh JS, Wu AY, Lai DM, Huang SJ, Jeng JS. Effect ofmannitol on cerebrovascular pressure reactivity in patients with intracranialhypertension. J Formos Med Assoc. 2013 Sep 30. 

 

  • Tai YC, Tang SC, Jeng JS. Teaching NeuroImages: spontaneous thalamic hemorrhage causing convergence excess. Neurology. 2013 Jul 23;81(4):e23-4.(correspondence)

 

  • Chen NC, Hsieh MJ, Tang SC, Chiang WC, Huang KY, Tsai LK, Ko PC, Ma MH, Jeng JS. Factors associated with use of emergency medical services in patients with acute stroke. Am J Emerg Med. 2013 May;31(5):788-91. 

 

  • Chen CH, Tang SC, Su YN, Yang CC, Jeng JS. Cardioembolic stroke related tolimb-girdle muscular dystrophy 1B. BMC Res Notes. 2013 Jan 29;6:32. (non-SCI)

 

  • Tang SC Wang YC, Li YI, Lin HC, Manzanero S, Hsieh YH, Phipps S, Hu CJ, Chiou HY, Huang YS, Yang WS, Mattson MP, Arumugam TV, Jeng JS. Functional role of soluble receptor for advanced glycation end products in stroke. Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):585-94. 

 

  • Fann DY, Lee SY, Manzanero S, Tang SC, Gelderblom M, Chunduri P, Bernreuther C, Glatzel M, Cheng YL, Thundyil J, Widiapradja A, Lok KZ, Foo SL, Wang YC, Li YI, Drummond GR, Basta M, Magnus T, Jo DG, Mattson MP, Sobey CG, Arumugam TV. Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke. Cell Death Dis. 2013 Sep 5;4:e790.

 

  • Broughton BR, Brait VH, Guida E, Lee S, Arumugam TV, Gardiner-Mann CV, Miller AA, Tang SC, Drummond GR, Sobey CG. Stroke increases g protein-coupled estrogen receptor expression in the brain of male but not female mice. Neurosignals.2013;21(3-4):229-39.

 

  • Yeh SJ, Tsai LK, Tang SC, Jeng JS (2014). Pin-Point Pupils with Drowsiness as a Presentation of Hashimoto's Encephalopathy Mimicking Pontine Infarction. Acta Neurol Taiwan. Mar;23(1):19-23.

 

  • Lin SY*, Tang SC*, Tsai LK, Yeh SJ, Hsiao YJ, Chen YW, Chen KH, Yip BS, Shen LJ, Wu FL, Jeng JS (2014). Orolingual angioedema after alteplase therapy of acute ischaemic stroke: incidence and risk of prior angiotensin-converting enzyme inhibitor use. Eur J Neurol. Jun 9. (equal first author) 

 

  •  Tang SC, Yeh SJ, Tsai LK, Hu CJ, Lien LM, Peng GS, Yang WS, Chiou HY, Jeng JS (2014). Association between plasma levels of hyaluronic acid and functional outcome in acute stroke patients. J Neuroinflammation. Jun 10;11(1):101.

 

  • Lin SY, Tang SC, Shen LJ, Jeng JS (2014). Prothrombin Complex Concentrate (Beriplex P/N)-related Renal and Cerebral Infarctions in a Patient with Warfarin-associated Intracerebral Hemorrhage. J Stroke Cerebrovasc Dis. 2014 Oct 1. (correspondence).

 

  • Wang KC*, Tang SC*, Lee JE, Lai DM, Huang SJ, Hsieh ST, Jeng JS, Tu YK (2014). Prognostic value of intrathecal heme oxygenase-1 concentration in patients with Fisher Grade III aneurysmal subarachnoid hemorrhage. J Neurosurg. 2014 Dec;121(6):1388-93. (equal first author).

 

  • Hsu PJ, Lee CW, Tang SC, Jeng JS (2014). Pearls & Oy-sters: Delayed traumatic intracerebral hemorrhage caused by cerebral venous sinus thrombosis. Neurology. 2014 Sep 30;83(14):e135-7 (correspondence).

 

 

  • Chen CH, Tang SC, Tsai LK, Hsieh MJ, Yeh SJ, Huang KY, Jeng JS (2014). Stroke code improves intravenous thrombolysis administration in acute ischemic stroke. PLoS One 2014 Aug 11;9(8):e104862.

 

  • Yeh SJ, Tang SC, Tsai LK, Jeng JS (2014). Pathogenetical subtypes of recurrent intracerebral hemorrhage: designations by SMASH-U classification system. Stroke. 2014 Sep;45(9):2636-42. doi: 10.1161/STROKEAHA.114.005598. Epub 2014 Jul 22

 

  • Hsieh MJ, Tang SC, Chiang WC, Huang KY, Chang AM, Ko PC, Tsai LK, Jeng JS, Ma MH Utilization of emergency medical service increases chance of thrombolytic therapy in patients with acute ischemic stroke. J Formos Med Assoc. 2014 Nov;113(11):813-9. (equal first author).

 

  • Fang YT, Wu VC, Tang SC, Yeh HM. Extracorporeal membrane oxygenation and sustained low-efficiency diafiltration successfully resuscitated propofol infusion syndrome during refractory status epilepticus. J Formos Med Assoc. 2015 Nov;114(11):1145-6. 

 

  • Chiu HC, Lin YH, Lo MT, Tang SC, Wang TD, Lu HC, Ho YL, Ma HP, Peng CK. Complexity of cardiac signals for predicting changes in alpha-waves after stress in patients undergoing cardiac catheterization. Scientific Report. 2015 Aug 19;5:13315.

 

  • Baik SH, Fane M, Park JH, Cheng YL, Yang-Wei Fann D, Yun UJ, Choi Y, Park JS, Chai BH, Park JS, Back SH, Jeong JI, Jang YJ, Bahn G, Lee JY, Li YI, Sobey CG, Uchida T, Park JH, Kim HT, Tang SC, Arumugam TV, Jo DG. Pin1 promotes neuronal death in stroke by stabilizing Notch intracellular domain. Annals of Neurology. 2015 Mar;77(3):504-16.

 

  • Tang SC, Huang PW, Hung CS, Shan SM, Lin YH, Shieh JS, Lai DM, Wu AY, Jeng JS. Identification of Atrial Fibrillation by Quantitative Analyses of Fingertip Photoplethysmogram. Sci Rep. 2017 Apr 3;7:45644.

 

  • Tang SC, Yin JH, Liu CH, Sun MH, Lee JT, Sun Y, Hsu CS, Sun MC, Lin CH, Chen CH, Lien LM, Muo CH, Jeng JS, Hsu CY; Taiwan Stroke Registry Investigators. Low Pulse Pressure After Acute Ischemic Stroke is Associated With Unfavorable Outcomes: The Taiwan Stroke Registry. J Am Heart Assoc. 2017 Jun 22;6(6). pii: e005113

 

 

  • Chen TC, Tang SC, Jeng JS. Rapid Progression of Vertebral Artery Occlusion After Radiotherapy for Nasopharyngeal Carcinoma. Acta Neurol Taiwan. 2017 Jun 15;26(2):76-77. (Correspondence).