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邱銘章教授兼主任研究成果

邱銘章教授兼主任(Ming-Jang Chiu)

  • TF Chen, CC Lin, YF Chen, HM Liu, MS, YC Huang, MJ Chiu *. Diffusion tensor changes in patients with amnesic mild cognitive impairment and various dementias. Psychiat Res: Neuroimag. 2009; 173:15-21. SCI

 

  • WH Wang, MS Hua, CC Yang, Y Chu, TW Cheng, PK Yip, MC Chiu, TF Chen, SJ Huang, HT Chen, WC Hsu. The Clinical Applicability of the Arithmetic, Digit Span Subtests of the Taiwan WAIS-III, and their Composite in Reflecting the Working Memory Index: A Retrospective Study. Chinese Journal of Psychology2008; 50: 187-199.

 

  • Tsai, K.J., Yang, C.H., Lee, P.C., Wang, W.T., Chiu, MJ, Shen, C.K.J., Asymmetric Expression Patterns of Brain Transthyretin in Normal Mice and A Transgenic Mouse Model of Alzheimer's Disease, Neuroscience 2009; 159:638-646.

 

  • TF Chen, YF Chen, Ting-Wen Tsang, MS Hua, HM Liu, MJ Chiu*. Executive dysfunction and periventricular diffusion tensor changes in mild cogn itive impairment and early Alzheimer's disease. Human Brain Mapping 2009; 30:3826-3836. SCI

 

  • TW Cheng, TF Che, PK Yip, MS Hua, CC Yang, MJ Chiu*. Comparison of behavioral and psychological symptoms of institution residents and memory clinic outpatients with Alzheimer's disease. International Psychogeriatrics. 2009. 21:1134-1141. SCI

 

  • MJ Chiu, CW Lin, CC Chen, TF Chen, YF Chen, HM Liu, CP Chu, HH Liou, MS Hua. Impaired gist memory in patients with temporal lobe epilepsy and hippocampal sclerosis. Epilepsia 2010; 51:1036-1042. SCI

 

  • TF Chen, RFS Huang, SE Lin, MJ Chiu*. Folic Acid Potentiates the Effect of Memantine on Spatial Learning and Neuronal Protection in an Alzheimer's Disease Transgenic Model. J Alzheimers Dis 2010; 20:607-615. SCI

 

  • Kwok YT Chen CY, Chiu MJ, Tang LY, Leung KK. Assessment of behavioral and psychological symptoms of dementia by family caregivers. Arch Gerontol Geriat r. 2010 Mar 4. [Epub ahead of print] PMID: 20207029. SCI

 

  • Chen C CH, Chiu MJ, Chen SP, Cheng CM, Huan GH. Patterns of cognitive change in elderly patients during and 6 months after hospitalization: A prospective cohort study. Int J Nurs Stud 2010 Apr 17  [Epub ahead of print] PMID:20403601 SCI（2/62）

 

  • JC Shan, MH. Hsieh, CM Liu, MJ Chiu, FS Jaw, HG Hwu. More evidence to support the role of S2 in P50 studies. Schizophr Res. 2010 Jun 17. [Epub ahead of print] PMID:20591267. SCI

 

  • N CC Yang, MJ Lee, CC Chao, YT Chuang, WM Lin, MF Chang, PC Hsieh, HW Kan, YH Lin, CC Yang, MJ Chiu, HH Liou, ST Hsieh. Clinical presentations and skin denervation in amyloid neuropathy due to transthyretin Ala97Ser. Neurology, 2010; 75:532-538. SCI

 

  • WH Chang, PF Tang, YH Wang, KH Lin, MJ Chiu, SHA Chen. Role of the premotor cortex in leg selection and anticipatory postural adjustments associated with a rapid stepping task in patients with stroke. Gait & Posture, 2010 Aug 9 [Epub ahead of print] PMID:20702094. SCI

 

  • Chen,CCH; Chiu,MJ; Chen,SP; Cheng,CM; Huang,GH.Patterns Of Cognitive   Change In Elderly Patients During And 6 Months After Hospitalisation: A rospective      Cohort Study. International Journal Of Nursing Studies 2011 MAR;48 (3):338-346

 

  • Chen,TF; Chiu,MJ; Huang,CT; Tang,MC; Wang,SJ; Wang,CC; Huang,RFS. Changes In Dietary Folate Intake Differentially Affect Oxidised Lipid  And Mitochondrial DNA Damage In Various Brain Regions Of Rats In The Absence/Presence Of Intracerebroventricularly Injected Amyloid  Beta-Peptide Challenge. British Journal Of Nutrition 2011MAY;105 (9) :1294-1302

 

  • Chiu,MJ; Horng,HE; Chieh,JJ; Liao,SH; Chen,CH; Shih,BY; Yang,CC; Lee,CL; Chen,TF; Yang,SY; Hong,CY; Yang,HC. Multi-Channel SQUID-Based Ultra-High-Sensitivity In-Vitro Detections  For Bio-Markers Of Alzheimer'sDisease Via Immunomagnetic Reduction. IEEE Transactions On Applied Superconductivity. 2011 JUN;21 (3):477-480

 

  • Hsu,JL; Hsieh,MH; Tseng,YL; Chiu,MJ; Liu,CM; Jaw,FS; Hwu,HG. Time-Frequency Analysis Of Mismatch Negativity In Schizophrenia Patients In Taiwan, Biomedical Engineering: Applications, Basis And Communications,Volume 23, Issue 4, Pages 287-293, 2011 

 

  • Kwok,YT; Chen,CY; Chiu,MJ; Tang,LY; Leung,KK . Assessment Of Behavioral And Psychological Symptoms Of Dementia By   Family Caregivers. ArchivesOf Gerontology And Geriatrics 2011 Jan-Feb;52 (1) :60-65

 

  • Lee,MJ; Chen,TF; Cheng,TW; Chiu,MJ . rs5848 Variant of Progranulin Gene Is a Risk of Alzheimer's Disease in   the Taiwanese Population. Neurodegenerative Diseases 2011;8 (4) :216-220

 

  • Lin,MS; Chiu,MJ; Wu,YW; Huang,CC; Chao,CC; Chen,YH; Lin,HJ; Li,HY; Chen,YF; Lin,LC; Liu,YB; Chao,CL; Tseng,WYI; Chen,MF; Kao,HL . Neurocognitive Improvement After Carotid Artery Stenting in Patients  With Chronic Internal Carotid Artery Occlusion and Cerebral Ischemia.STROKE 2011 OCT;42 (10) :2850-2854

 

  • Sheu,YH; Hsieh,MH; Liu,HH; Chiu,MJ; Liu,CM; Jaw,FS; Hwu,HG. A Study of  Dipole Source Reconstruction of Auditory Duration and  Frequency Mismatch Negativity in Schizophrenia. Biological Psychiatry 2011 May;69 (9) :176-

 

  • Shih,YH; Yen,AMF; Yen,DJ; Hung,LP; Chen,HH; Liou,HH. A Novel Postoperative Seizure Classification for Long-term Mortality of  Patients With Intractable Epilepsy: Comparison With the Engel System. Neurosurgery 2011 Jul; 69 (1) 64-70

 

  • Wang,WH; Liou,HH; Chen,CC; Chiu,MJ; Chen,TF; Cheng,TW; Hua,MS. Neuropsychological performance and seizure-related risk factors in patients withtemporal lobe epilepsy: A retrospective cross-sectional study. Epilepsy &Behavior 2011 Dec;22 (4) :728-734

 

  • Wu,YY; Cheng,IHJ; Lee,CC; Chiu,MJ; Lee,MJ; Chen,TF; Hsu,JL.Clinical Phenotype of G206D Mutation in the Presenilin 1 Gene in   Pathologically Confirmed Familial Alzheimer's Disease. Journal Of Alzheimers Disease 2011;25 (1) :145-150

 

  • AT Ta, SE Huang, MJ Chiu, MS Hua, WYI Tseng, SHA Chen, A Qiu. Age-Related Vulnerabilities Along The Hippocampal Longitudinal Axis. Human Brain Mapping 2012 33:2415-27.

 

  • Lin MS, Chiu, MJ, Li, HY, Kao, Hsien-Li. Response to Letter Regarding Article "Neurocognitive Improvement After Carotid Artery Stenting in Patients With Chronic Internal Carotid Artery Occlusion and Cerebral Ischemia" . Stroke 2012; 43: E11-E11.  

 

  • Cheng CM, Chiu MJ, Wang JH, Liu HC, Shyu YI, Huang GH, Chen C C-H. Cognitive stimulation during hospitalization improves global cognition of older Taiwanese undergoing elective total knee and hip replacement.. Journal of Advanced Nursing. 2012; 68: 1322-9.

 

  • RL Yu, RM Wu, MJ Chiu, CH Tai, CH Lin, MS Hu. Advanced Theory of Mind in patients at early stage of Parkinson's diseaseq . Parkinsonism and Relat Disord. 2012; 18:21-4.

 

  • Chen YH, Lin MS, Lee JK, Chao CL, Tang SC, Chao CC, Chiu MJ, Wu YW, Chen YF, Shih TF, Kao HL. Carotid stenting improves cognitive function in asymptomatic cerebral ischemia. Int J Cardiol. 2012; 157:104-7.

 

  • Lin YT, Liu CM, Chiu MJ, Liu CC, Chien YL, Hwang TJ, Jaw FS, Shan JC, Hsieh MH, Hwu HG. Differentiation of schizophrenia patients from healthy subjects by mismatch negativity and neuropsychological tests. . PLoS One. 2012;7(4):e34454.

 

  • Hsieh MH, Shan JC, Huang WL, Cheng WC, Chiu MJ, Jaw FS, Hwu HG, Liu CC. Auditory event-related potential of subjects with suspected pre-psychotic state and first-episode psychosis. Schizophr Res. 2012; 140: 243-9.

 

  • Chiu MJ*, Yang SY, Chen TF, Chieh JJ, Hung TZ, Yip PK, Yang HC, Cheng TW, Chen YF, Hua MS, Hong HE. New assay for old markers - plasma beta amyloid of mild cognitive impairment and Alzheimer's disease.  Curr Alzheimer Res 2012; 9: 1142-48.

 

  • Fan LY, Chen TF, Chiu MJ*. Current and Future Pharmacological Treatment of Alzheimer's Disease (阿茲海默症藥物治療的現在與未來). Formosa J Med 2012; 14:397-403.

 

  • Lin CH, Chen YF, Tzen KY, Chiu MJ*. Imaging and Biomarkers in Alzheimer's Disease (阿茲海默症神經影像及生物指標). Formosa J Med 2012; 14:372-381.

 

  • Liao WC, Tsai SY, Kuo CP, Wang L, Lo C, Ting H, Chiu MJ*. Discrepancy and association between perceived sleep state and objective sleep measures in older adults with sleep complaints. J Aging Res & Clin Practice 2013; 2(1): 142-147.

 

  • Yang SY, Chieh JJ, Yang CC, Liao SH, Chen HH, Horng HE, Yang HC, Hong CY, Chiu MJ, Chen TF, Huang KW, and Wu CC. Clinic Applications in Assaying Ultra-low-concentration Bio-markers Using HTS SQUID-based AC Magnetosusceptometer. IEEE Trans. Appl. Supercond. (Accepted 2012/10/09)

 

  • Shan JC, Liu CM, Chiu MJ, Liu CC, Chien YL, Hwang TJ, Lin YT, Hsieh MH, Jaw FS, Hwu HG. A Diagnostic Model Incorporating P50 Sensory Gating and Neuropsychological Tests for Schizophrenia. PLoS ONE 2013; 8(2):e 57197. Doi : 10.1371/journal.pone.0057197. SCI

 

  • Li YH, Chiu MJ, Yeh ZT, Liou HH, Cheng TW, Hua MS. Theory of Mind in Patients with Temporal Lobe Epilepsy. J Int Neuropsychol Soc 2013; 19: 594-600. SCI

 

  • CP Shen, CC Chen, SL Hsieh, WH Chen, JM Chen, CM Chen, F Lai, MJ Chiu*. High-performance seizure detection system using a wavelet-approximate entropy-fSVM cascade with clinical validation. Clin EEG Neurosci. 2013 Oct; 44(4):247-56. [Epub ahead of print]. SCI

 

  • Huang CC, Chen YH, Lin MS, Lin CH, Li HY, Chiu MJ, Chao CC, Wu YW, Chen YF, Lee JK, Wang MJ, Chen MF, Kao HLJ Am Coll Cardiol. Association of the Recovery of Objective Abnormal Cerebral Perfusion with Neurocognitive Improvement after Carotid Revascularization. J Am Coll Cardiol 2013; 61:2503-2509. SCI

 

  • CP Shen, ST Liu, WZ Zhou, FS Lin, A YY Lam, HY Sung, W Chen, JW Lin, MJ Chiu*, MK Pan, JH Kao, JM Wu, Fp Lai. A Physiology-Based Seizure Detection System for Multichannel EEG. PLoS ONE 2013; 8(6): e65862. SCI

 

  • WC Liao, L Wang, CP Kuo, L Chy, MJ Chiu, H Ting. Effect of a warm footbath before bedtime on body temperature and sleep in older adults with good and poor sleep: An experimental crossover trial. Int J Nurs Stud 2013; pii: S0020-7489(13)00113-2. SCI

 

  • MJ Chiu*, YF Chen, TF Chen, SY Yang, FP G. Yang, TW Tseng, JJ Chieh, JC R. Chen, KY Tzen, MS Hua, HE Horng*. Plasma Tau as a Window to the Brain – Negative Associations with Brain Volume and Memory Function in Mild Cognitive Impairment and Early Alzheimer's Disease. Hum Brain Mapp. 2013 Oct 15. doi: 10.1002/hbm.22390. [Epub ahead of print] SCI

 

  • Chiu MJ, Yang SY, Horng HE, Yang CC, Chen TF, Chieh JJ, Chen HH, Chen TC, Ho CS, Chang SF, Liu HC, Hong CY, Yang HC. Combined Plasma Biomarkers for Diagnosing Mild Cognition Impairment and Alzheimer's Disease. ACS Chem Neurosci. 2013 Dec 18;4(12):1530-6. SCI

 

  • Chen TF, Tang MC, Chou CH, Chiu MJ, Huang RF. Dose-dependent folic acid and memantine treatments promote synergistic or additive protection against Aβ (25-35) peptide-induced apoptosis in SH-SY5Y cells mediated by mitochondria stress-associated death signals. Food Chem Toxicol. 2013; 62:538-47.

 

  • Chiu MJ*. Systemic infection may cause cognitive decline and neurodegeneration. Critic Care Med 2014; 42:1282-1283. Invited editorial. SCI

 

  • YC Lin, YC Shih, WY I Tseng, YH Chu, MT Wu, TF Chen, PF Tang*, MJ Chiu*. Cingulum correlates of cognitive functions in patients with mild cognitive impairment and early Alzheimer's disease - A diffusion spectrum imaging study. Brain Topography 2014 Jan 11. [Epub ahead of print]. SCI

 

  • LY Fan, MJ Chiu*. Combotherapy and current concepts as well as future strategies for the treatment of Alzheimer's disease. Neuropsychiatric Disease and Treatment 2014 Mar 11;10:439-51. doi: 10.2147/NDT.S45143

 

  • CH Lin, TF Chen, MJ Chiu, RM Wu. Lack of C9orf72 repeat expansion in Taiwanese patients with mixed neurodegenerative disorders. Frontiers in Neurology, 2014 Apr 28;5:59. doi: 10.3389/fneur.2014.00059.

 

  • Li HC, Chen YS, Chiu MJ, Fu MC, Huang GH, Chen CCH. (2014). Delirium, Subsyndromal Delirium, and Cognitive Changes in Individuals Undergoing Elective Coronary Artery Bypass Graft Surgery. Journal of Cardiovascular Nursing, 2014 Jun 24. [Epub ahead of print].

 

  • Tzen KY, Yang SY, Chen TF, Cheng TW, Horng HE, Wen HP, Huang YY, Shiue CY, Chiu MJ*. Plasma Aβ but Not Tau is Related to Brain PiB Retention in Early Alzheimer's Disease. ACS Chem Neurosci. 2014 Aug 13. [Epub ahead of print]

 

  • Sun Y, Lee HJ, Yang SC, Chen TF, Lin KN, Lin CC, Wang PN, Tang LY, Chiu MJ*.A nationwide survey of mild cognitive impairment and dementia, including very mild dementia, in Taiwan. PLoS One. 2014 Jun 18;9(6):e100303. doi: 10.1371/journal.pone.0100303.

 

  • Chen YH, Leong WS, Lin MS, Huang CC, Hung CS, Li HY, Chan KK, Yeh CF, Chiu MJ and Kao HL. Predictors for Successful Endovascular Intervention in Chronic Carotid Artery Total Occlusion. JACC Cardiovasc Interv. 2016;9:1825-32.

 

  • Yang SY, Chiu MJ, Lin CH, Horng HE, Yang CC, Chieh JJ, Chen HH and Liu BH. Development of an ultra-high sensitive immunoassay with plasma biomarker for differentiating Parkinson disease dementia from Parkinson disease using antibody functionalized magnetic nanoparticles. J Nanobiotechnology. 2016;14:41.

 

  • Lee NC, Yang SY, Chieh JJ, Huang PT, Chang LM, Chiu YN, Huang AC, Chien YH, Hwu WL and Chiu MJ. Blood Beta-Amyloid and Tau in Down Syndrome: A Comparison with Alzheimer's Disease. Front Aging Neurosci. 2016;8:316.

 

  • Chin-Hsien Lin, Shieh-Yueh Yang, Herng-Er Horng, Che-Chuan Yang, Jen-Jie Chieh, Hsin-Hsien Chen, Bing-Hsien Liu, Ming-Jang Chiu. Plasma α-synuclein predicts cognitive decline in Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry 2017 Oct;88(10):818-824

 

  • Shieh-Yueh Yang*, Ming-Jang Chiu, Ta-Fu Chen, Chin-Hsien Lin, Jiann-Shing Jeng, Sung-Chun Tang, Yen-Fu Lee, Che-Chuan Yang, Bing-Hsien Liu, Hsin-Hsien Chen, and Chau-Chung Wu. Analytical performance of reagent for assaying tau protein in human plasma and feasibility study screening neurodegenerative diseases. Scientific Reports 2017 Aug 24;7(1):9304. doi: 

 

  • Han ML, Chen JH, Tsai MK, Liou JM, Chiou JM, Chiu MJ, Chen YC.     Association between Helicobacter pylori infection and cognitive impairment in the elderly. J Formos Med Assoc. 2017 Nov 23. pii: S0929-6646(17)30624-1.

 

  • Hsieh CY, Huang HC, Wu DP, Li CY, Chiu MJ, Sung SF. Effect of Rehabilitation Intensity on Mortality Risk After Stroke. Arch Phys Med Rehabil. 2017 Nov 3. pii: S0003-9993(17)31334-5.

 

  • Wang CY, Wang PN, Chiu MJ, Finstad CL, Lin F, Lynn S, Tai YH, De Fang X, Zhao K, Hung CH, Tseng Y, Peng WJ, Wang J, Yu CC, Kuo BS, Frohna PA. UB-311, a novel UBITh amyloid  peptide vaccine for mild?Alzheimer's?disease. Alzheimers Dement (N Y). 2017 Apr 14;3(2):262-272. 

 

  • Lue LF, Sabbagh MN, Chiu MJ, Jing N, Snyder NL, Schmitz C, Guerra A, Belden CM, Chen TF, Yang CC, Yang SY, Walker DG, Chen K, Reiman EM. Plasma Levels of A-beta 42 and Tau Identified Probable Alzheimer's Dementia: Findings in Two Cohorts. Front Aging Neurosci. 2017 Jul 24;9:226.