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Shu-Hua Yang, M.D., Ph.D.

Associate Professor, Orthopedics, National Taiwan University College of Medicine

Chief of Spinal Surgery, Department of Orthopedics, National Taiwan University Hospital

Attending Surgeon, Department of Orthopedics, National Taiwan University Hospital

Executive Council Member, Taiwan Spine Society

Council Member, Asia Pacific Spine Society

 

Education

M.D.: Medical School, National Taiwan University

Ph.D.: Graduate Institute of Biomedical Engineering, National Taiwan University

 

Clinical Specialties

Spinal Surgery for

Degenerative Spinal Disorders, Spinal Deformity/Scoliosis/Kyphosis, Spinal Neoplasms, Spinal Infections, Spinal Trauma/Fractures

Spinal Osteotomities for Spinal Deformities

Minimally Invasive Spinal Surgery

 

Clinic Hours

Tuesday, Friday 09:00-13:00

 

Professional Experiences

Resident and Chief Resident, Orthopedics, National Taiwan University Hospital

Attending Surgeon, Orthopedic Surgery, Poh-Ai Hospital, Lotung, Yi-Lan, Taiwan

Adjunct Lecturer, Orthopedics, National Taiwan University College of Medicine

Clinical Fellow, Spinal Surgery, Orthopedic Surgery, Johns Hopkins Medical Center

Research Fellow, Biomedical Engineering, Johns Hopkins University

Adjunct Assistant Professor, Orthopedics, National Taiwan University

Chief, Orthopedics, National Taiwan University Hospital Yun-Lin Branch

Visiting Scholar, Spinal Surgery, Orthopaedics, Rush University Medical Center

 

Professional Memberships

Taiwan Orthopaedic Association, Professional Member Since 1997

Taiwan Spine Society. Professional Member Since 1999, Council Member 2000-2018, Executive Council Member 2016-2018

Asia Pacific Orthopedic Association, Professional Member Since 1999, Council Member since 2016

Orthopaedic Research Society, USA, Active Member Since 2008

Scoliosis Research Society, USA, Candidate Member Since 2013

Taiwanese Osteoporosis Association, Professional Member Since 1998, Council Member 2001-2003, Secretary General, 2005-2007

Formosan Medical Association, Taiwan. Professional Member Since 1995

AOSpine, Member since 2007, National Delegate 2010-2012

 

Honors and Awards

Best Paper Award, Annual Meeting, Taiwan Orthopaedic Association, 2002

Best Research Paper of the Year, Journal of Orthopedic Surgery, Taiwan, 2003

Best Paper Award, Annual Meeting, Taiwan Orthopaedic Association, 2004

Top Scored Spine Poster, Orthopaedic Research Society (USA), 2009

Best Paper Award, Annual Meeting, Taiwan Spine Society, 2010

Outstanding Teaching Award, NTU Hospital Yun-Lin Branch, 2010

Outstanding Advisor Award, School of Medicine, National Taiwan University, 2014

 

Research Topics

Regeneration of intervertebral discs

Characteristics of intervertebral disc cells

Tissue engineering and biomechanics of spine and Orthopedics

Image analysis for intervertebral disc degeneration

 

Scientic Publications in Recent 5 Years

  1. Ming-Hsiao Hu, Li-Wei Hung, Shu-Hua Yang*, Yuan-Hui Sun, Tiffany Ting-Fang Shih, Feng-Huei Lin. Lovastatin promotes redifferentiation of human nucleus pulposus cells during expansion in monolayer culture. Artificial Organs 2011 Apr, 35(4):411-416 (SCI) (Corresponding author)
  2. Kuan-Wen Wu, Ming-Hsiao Hu, Shier-Chieg Huang, Ken N Kuo, Shu-Hua Yang*. Giant ganglionic cyst of the hip as a rare cause of sciatica. Journal of Neurosurgery: Spine 2011 Apr, 14(4):484-487. (SCI) (Corresponding author)
  3. Yung-Hsin Cheng, Shu-Hua Yang, Kai-Chiang Yang, Moon-Pei Chen, Feng-Huei Lin. The effects of ferulic acid on nucleus pulposus cells under hydrogen peroxide-induced oxidative stress. Process Biochemistry 2011 Aug, 46(8):1670-1677 (SCI)
  4. Yung-Hsin Cheng, Shu-Hua Yang, Feng-Huei Lin. Thermosensitive chitosan- gelatin-glycerol phosphate hydrogel as a controlled release system of ferulic acid for nucleus pulposus regeneration. Biomaterials 2011 Oct, 32(29):6953-6961 (SCI)
  5. Chang-Chin Wu, Kai-Chiang Yang, Shu-Hua Yang, Min-Huei Lin, Tzong-Fu Kuo, Feng-Huei Lin. In vitro studies of composite bone filler based on poly(propylene fumarate) and biphasic α-tricalcium phosphate/hydroxyapatite ceramic powder. Artificial Organs 2012 April, 36(4):418-428. (SCI)
  6. Chang-Chin Wu, Shu-Hua Yang, Teng-Le Huang, Chia-Ching Liu, Dai-Hua Lu, Kai-Chiang Yang, Feng-Huei Lin. The interaction between co-cultured human nucleus pulposus cells and mesenchymal stem cells in a bioactive scaffold. Process Biochemistry 2012 June, 47(6):922-928 (SCI)
  7. Yu-Chun Chen, Wen-Yu Su, Shu-Hua Yang, Amit Gefen, Feng-Huei Lin. In situ forming hydrogels composed of oxidized high molecular weight hyaluronic acid and gelatin for nucleus pulposus regeneration. Acta Biomaterialia 2013 Feb, 9(2): 5181-5193 (SCI)
  8. Yung-Hsin Cheng, Shu-Hua Yang, Chia-Ching Liu, Amit Gefen, Feng-Huei Lin. Thermosensitive hydrogel made of ferulic acid-gelatin and chitosan glycerol phosphate. Carbohydrare Polymers 2013 Feb, 92(2):1512-1519. (SCI)
  9. Kai-Chiang Yang, Chang-Chin Wu, Shu-Hua Yang, Chien-Chang Chiu, Shoichiro Sumi, Hsuan-Shu Lee. Investigating the suspension culture on aggregation and function of mouse pancreatic β-cells. Journal of Biomedical Materials Research: Part A 2013 Aug, 101(8):2273-2282. (SCI)      
  10. Shu-Hua Yang, Ming-Hsiao Hu, Yuan-Hui Sun, Feng-Huei Lin. Differential phenotypic behaviors of human degenerative nucleus pulposus cells under normal and hypoxic conditions: influence of oxygen concentration during isolation, expansion, and cultivation. The Spine Journal 2013 Nov, 13(11):1590-1596. (SCI)
  11. Jawl-Shan Hwang, Keh-Sung Tsai, Yuh-Min Cheng, Wen-Jer Chen, Shih-Te Tu, Ko-Hsiu Lu, Sheng-Mou Hou, Shu-Hua Yang, Henrich Cheng, Hung Jen Lai, Sharon Lei, Jung-Fu Chen. Vitamin D status in non-supplemented postmenopausal Taiwanese women with osteoporosis and fragility fracture. BMC Musculoskeletal Disorders 2014 Jul, 15(1): 257. (SCI)
  12. Ming-Hsiao Hu, Kai-Chiang Yang, Yeong-Jang Chen, Yuan-Hui Sun, Shu-Hua Yang*. Lovastatin prevents discography-associated degeneration and maintains the functional morphology of intervertebral discs. The Spine Journal 2014 Oct, 14(10) 2459-2466. (SCI) (Corresponding author)
  13. Shu-Hua Yang*, Ming-Hsiao Hu, Kuo-Yuan Huang, Shan-Chih Chen, Ruey-Mo Lin, Po-Quang Chen. Surgical technique and clinical outcomes for primary intradural extremedullary spinal tumors. Formosan Journal of Musculoskeletal Disorders 2015 Feb, 6(1):16-22. (Corresponding author)
  14. Ana Chee, Peng Shi, Thomas Cha, Ting-Hsien Kao, Shu-Hua Yang, Jun Zhu, Ding Chen, Yejia Zhang, Howard S An. Cell therapy with human dermal fibroblasts enhances intervertebral disc repair and decrease inflammation in the rabbit model. Global Spine Journal (Accepted)
  15. Chang-Chin Wu, Li-Ho Hsu, Shoichiro Sumi, Kai-Chiang Yang, Shu-Hua Yang*. Injectable and biodegradable Composite bone filler composed of poly(propylene fumarate) and calcium phosphate ceramic for vertebral augmentation procedure: an in vivo procine study. Journal of Biomedical Materials Research: Part B – Applied Biomaterials (SCI) (Accepted)

Invited Speeches in Recent 5 Years

  1. Laminoplasty for multilevel cervical myelopathy. AOSpine Advances Seminar in Cervical Spine, Taipei, Taiwan, 2011.
  2. Short fusion for degenerative scoliosis. AOSpine Principles Course in Elderly Spinal Problem Management, Hong Kong, 2011.
  3. Surgical options of osteoporotic spinal collapse. AOSpine Principles Course in Elderly Spinal Problem Management, Hong Kong, 2011.
  4. Salvage for failed cases. AOSpine Principles Course in Elderly Spinal Problem Management, Hong Kong, 2011.
  5. Complications of vertebroplasty and managements. Annual Meeting of Taiwan Society of Minimally Invasive Spine Surgery, Taichung, Taiwan, 2012.
  6. Relationships between parameters for MR signal homogeneity in nucleus pulposus and stages of early intervertebral disc degeneration. 21st Taiwan-Japan Orthopaedic Symposium, Tainan, Taiwan, 2013.
  7. Anatomical evaluation of cervical spine: osteology, vascular anatomy in relation to surgical treatment. AOSpine Principles Seminar, Ho Chi Minh City, Vietnam, 2013.
  8. How to manage upper cervical spinal injury. AOSpine Principles Seminar, Ho Chi Minh City, Vietnam, 2013.
  9. Anatomical evaluation of thoracolumbar spine in relation to surgical treatment. AOSpine Principles Seminar, Ho Chi Minh City, Vietnam, 2013.
  10. Surgical options for adult degenerative scoliosis – from decompression alone, various lengths of spinal fusion, to spinal osteotomies. Philippine Spine Society, Manila, Philippines, 2014.
  11. Assessment of sagittal alignment and spinopelvic relationship. AOSpine Principles Course, Yangon, Myanmar, 2014.
  12. Degenerative scoliosis with sagittal malalignment. AOSpine Principles Course, Yangon, Myanmar, 2014.
  13. Upper cervical spine injury: assessment, classification and managements. AOSpine Principles Course, Yangon, Myanmar, 2014.
  14. Complications of spinal surgery. Seminars on State-of-Art in Spinal Surgery. Taiwan Spine Society, Taipei, 2015.
  15. Analysis of short-term subsequent proce​dures after percutaneous vertebroplasty and salvage surgery for disabling cement-related complications. 23rd Taiwan-Japan Orthopaedic Symposium, Hualien, Taiwan, 2015.
  16. Application of posterior vertebral column resection to reconstruction of vertebral body defect in lumbar spine. PVCR Summit Forum, Kunming, China, 2015.
  17. Application of spinal osteotomies to adult spinal deformity. Spine Summit Asia Pacific, Hong Kong, 2015. Taiwan Spine Society, Tainan, Taiwan, 2015.
  18. Researches on tissue repair/regeneration for nucleus pulposus of intervertebral disc. Annual Meeting of Taiwan Orthopedic Association, Taipei, Taiwan, 2015.
  19. Kurokawa spinous process-splitting laminoplasty for cervical spinal stenosis. Taiwan Spine Society, Tainan, Taiwan, 2015.
  20. Application of spinal osteotomies to adult spinal deformity. Taiwan Spine Society, Tainan, Taiwan, 2015.
  21. Surgical technique and clinical outcomes for primary intradural extramedullary spinal tumors. Taiwan Spine Society, Tainan, Taiwan, 2015.
  22. Tumor of the spine. Current state-of-the-art and the Orthopedic role in intraspinal tumors. Taiwan Spine Society, Taipei, 2016.
  23. Surgical strategy of spinal osteotomies for adult spinal deformity. 24th Japan-Taiwan Orthopaedic Symposium, Fukushima, Japan, 2016.


Research Projects in Recent 5 Years

  1. "The influence of hypoxic culture environment on regenerative potential of human nucleus pulposus cells", Principal Investigator, Aug. 2010 – July 2013, National Science Council, Taiwan. NSC 99-2628-B-002-041-MY3
  2. "The effect of modified hyaluronan hydrogel and Sirolimus drug-elution on the prevention of epidural fibrosis - In vitro cell culture and rat laminectomy model", Principal Investigator, Aug. 2013 – July 2015, Ministry of Science and Technology, Taiwan. NSC 102-2314-B-002-043-MY2
  3. Identification, characteristics, purification and optimization of culture condition for cell subpopulations in human nucleus pulposus, Principal Investigator, Aug. 2015 – July 2016, Ministry of Science and Technology, Taiwan. MOST 104-2314-B-002-049
  4. In vivo study for comparison between lipophilic and hydrophilic statins on regeneration potential of nucleus pulposus cells. Co-Investigator, Aug. 2015 – July 2016, Ministry of Science and Technology, Taiwan. MOST 104-2314-B-002-009
  5. Comparison of Transforming Growth Factor-b1 and Lovastatin on Differentiating Mesenchymal Stem Cells Toward Nucleus Pulposus-Like Phenotype. Principal Investigator, Jan – Dec 2016, National Taiwan University Hospital, NTHU 105-S3112.