郭鐘金教授(Chung-Chin Kuo Chairperson)

• Yang, Y.-C., Hsieh, J.-Y., and Kuo C.-C.* (2009) The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na+ channel. Journal of General Physiology 134:95-113

 

• Yang, Y.-C., Lee, C.-H., and Kuo C.-C.* (2010) Ionic flow enhances low-affinity binding: a revised mechanistic view into Mg2+ block of NMDA receptors. Journal of Physiology 588:633-650

 

• Yang, Y.-C., Huang, C.-S., and Kuo C.-C.* (2010) Lidocaine, Carbamazepine, and Imipramine Have Partially Overlapping Binding Sites and Additive Inhibitory Effect on Neuronal Na+ Channels. Anesthesiology 113:160-174

 

• Tai,CH; Yang,YC; Pan,MK; Huang,CS; Kuo,CC. Modulation of subthalamic T-type Ca2+ channels remedies locomotor   deficits in a rat model of Parkinson disease. Journal of  clinical Investigation 2011 Aug;121 (8) :3289-3305

 

• Yang,YC; Lin,S; Chang,PC; Lin,HC; Kuo,CC.Functional Extension of Amino Acid Triads    from the Fourth Transmembrane Segment (S4) into Its External Linker in Shaker K+     Channels. Journal Of Biological Chemistry 2011 Oct 28;286    (43) :37503-37514

 

• Tai CH, Pan MK, Lin JJ, Huang CS, Yang YC, Kuo CC. Subthalamic discharges as a causal determinant of parkinsonian motor deficits.     Ann Neurol. 2012Sep;72(3):464-76.

 

• Huang, C.-W., Kuo, C.-C. (2013) The bundle crossing region is responsible for the inwardly rectifying internal spermine block of the Kir2.1 channel. Pflugers Arch - Eur J Physiology DOI10.1007/s00424-013-1322-0

 

• Huang, C.-W.,  Kuo, C.-C. (2014) The bundle crossing region is responsible for the inwardly rectifying internal spermine block of the Kir2.1 channel. Pflugers Arch - Eur J Physiology 466 (2):275-293

 

• Yang, Y.-C., Tai, C.-H., Pan, M.-K., Kuo, C.-C. (2014) The T-type calcium channel as a new therapeutic target for Parkinson's disease. Pflugers Arch - Eur J Physiology 466:747-755

 

• Huang, C.-W.,  Kuo, C.-C. (2014) Gating of the Kir2.1 channel at the bundle crossing region by spermine and other intracellular cations. Journal of Cellular Physiology 229(11):1703-21

 

• Pan, M.-K., Tai, C.-H., Lin, W.-C., Pei, J.-C., Lai, W.-S., Kuo, C.-C. (2014) Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits. Journal of Clinical Investigation 124(10):4629-4641  

 

• Huang CW and Kuo CC. A synergistic blocking effect of Mg(2)(+) and spermine on the inward rectifier K(+) (Kir2.1) channel pore. Sci Rep. 2016;6:21493. 

 

• Huang CW, Lai HJ, Huang PY, Lee MJ and Kuo CC. The Biophysical Basis Underlying Gating Changes in the p.V1316A Mutant Nav1.7 Channel and the Molecular Pathogenesis of Inherited Erythromelalgia. PLoS Biol. 2016;14:e1002561.

 

• Tu YC, Yang YC and Kuo CC. Modulation of NMDA channel gating by Ca2+ and Cd2+ binding to the external pore mouth. Sci Rep. 2016;6:37029.

 

• Pan MK, Kuo SH, Tai CH, Liou JY, Pei JC, Chang CY, Wang YM, Liu WC, Wang TR, Lai WS and Kuo CC. Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control. J Clin Invest. 2016;126:4516-4526.