▍經歷
- Associate Researcher, Department of Medical Research, National Taiwan University Hospital
- Assistant Researcher, Department of Medical Research, National Taiwan University Hospital
- Postdoctoral Researcher, Department of Medical Research, National Taiwan University Hospital
- Postdoctoral Researcher, Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University
- Postdoctoral Researcher, Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University
▍主要專長
- Biochemistry
- Virological Immunology
- Vaccinology
- Cancer Immunology
▍研究方向
- Vaccine and Adjuvant Development
- Antiviral Drug Development
- Tumor Immunotherapy
- Immune Modulation and Natural Antioxidants
▍近五年論文發表
- Chuang KT, Pan SC, Chiang BL, Chen SH, Pan MH, Chen YL, Lin CS, Pan CK, Lin JY, and Lin YL* Pterostilbene exhibits broad-spectrum antiviral activity by targeting the enterovirus capsid, inactivating viral particles, blocking viral binding, and protecting mice from lethal EV-A71 challenge. Phytotherapy Research, 2025 Apr; 39:2672-2688. DOI: 10.1002/ptr.8496
- Chen YL, Chung BH, Mimaki M, Uchino S, Chien YH, Mak CC, Peng SS, Wang WC, Lin YL, Hwu WL, Lee SJ, Lee NC. NDUFB7 mutations cause brain neuronal defects, lactic acidosis, and mitochondrial dysfunction in humans and zebrafish. Cell Death Discovery, 2025 Mar; 11(1):82. DOI: 10.1038/s41420-025-02369-0
- Chin CL, Lin YL, Cheng PY, Lee P, Chiang BL. Effective mucosal adjuvantation of the intranasal Enterovirus A71 vaccine with zymosan. Immunology, 2025 Mar; 174(3):349-362. DOI: 10.1111/imm.13895
- Chung KP, Chen YH, Chen YJ, Chien JY, Kuo HC, Huang YT, Ruan SY, Lin YL, Chen YF, Keng LT, Kuo LC, Ku SC, Kuo CH, Yu CJ; TAiwan CollaboraTive Intensive Care Study group (TACTICS). Increased circulatory Krebs cycle metabolites in sepsis is associated with increased interleukin-6 release and worse survival. Shock, 2025 Jan 14. DOI: 10.1097/SHK.0000000000002550
- Chen JL, Pan CK, Huang YS, Tsai CY, Wang CW, Kuo SH, Shieh MJ, Lin YL* Combination of ataxia telangiectasia and Rad3-related inhibition with ablative radiotherapy remodels the tumor microenvironment and enhances immunotherapy response in lung cancer. Cancer Immunology Immunotherapy, 2024 Nov; 74(1):8. DOI: 10.1007/s00262-024-03864-6
- Chuang YT, Lin YL, Lin JY. Licochalcone A regulates viral IRES activity to inhibit enterovirus replication. Antiviral Research, 2024, Jan; 221:105755. DOI: 10.1016/j.antiviral.2023.105755
- Lin YL, Cheng PY, Chin CL, Chuang KT, Lin JY, Chang N, Pan CK, Lin CS, Pan SC, Chiang BL. A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge. Journal of Biomedical Science, 2023, Dec; 30(1):96. DOI: 10.1186/s12929-023-00987-3
- Chen JL, Pan CK, Lin LC, Tsai CY, Kuo CY, Huang YS, Lin YL*. Therapeutic efficacy of cyclin-dependent kinase inhibition in combination with ionizing radiation for lung cancer. International Journal of Radiation Biology, 2023, Aug; 99(8):1257-1266. DOI: 10.1080/09553002.2023.2161658
- Chen JL, Yang SJ, Pan CK, Lin LC, Tsai CY, Wang CH, Huang YS, Lin YL*, Kuo SH, Shieh MJ. (*Corresponding author) Cisplatin and albumin-based gold-cisplatin nanoparticles enhance ablative radiotherapy-induced antitumor immunity in local and distant tumor microenvironment. International Journal of Radiation Oncology Biology Physics, 2023, Aug; 116(5):1135-1149. DOI: 10.1016/j.ijrobp.2023.02.014
- Huang JH, Lin YL, Wang LC, Chiang BL. M2-like macrophages polarized by Foxp3− Treg-of-B cells ameliorate imiquimod-induced psoriasis. Journal of Cellular and Molecular Medicine, 2023, Jun; 27(11):1477-1492. DOI: 10.1111/jcmm.17748
- Chen JL, Pan CK, Lin YL*, Tsai CY, Huang YS, Yang WC, Hsu FM, Kuo SH, Shieh MJ. (*Corresponding author) Preclinical evaluation of PEGylated liposomal doxorubicin as an effective radiosensitizer in chemoradiotherapy for lung cancer. Strahlentherapie und Onkologie, 2021, Dec; 197(12):1131-1142. DOI: 10.1007/s00066-021-01835-9
- Chen JL, Pan CK, Huang YS, Tsai CY, Wang CW, Lin YL*, Kuo SH, Shieh MJ. (*Corresponding author) Evaluation of antitumor immunity by a combination treatment of high‑dose irradiation, anti‑PDL1, and anti‑angiogenic therapy in murine lung tumors. Cancer Immunology, Immunotherapy, 2021 Feb;70(2):391-404. DOI: 10.1007/s00262-020-02690-w
- Lin YL, Shih Chiaho, Cheng PY, Chin CL, Liou AT, Lee PY, Chiang BL. A Polysaccharide Purified From Ganoderma lucidum Acts as a Potent Mucosal Adjuvant That Promotes Protective Immunity Against the Lethal Challenge With Enterovirus A71. Frontiers in immunology, 2020, Sep; 29:11:561758. DOI: 10.3389/fimmu.2020.561758
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