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莊雅婷副研究員

▍聯繫資訊
  • 辦公室：第三共研
  • 電話：院內分機265720
  • Email：ytchuang1976@ntuh.gov.tw
  • 實驗室網站：（建置中）
 林郁里副研究員
▍學歷
  • 2002-2008   Ph.D. in Immunology, College of Medicine, National Taiwan University
  • 1998-2000   MSc in Microbiology and Immunology, College of Life Science, National Yang-Ming University
  • 1994-1998   BSc in Zoology, College of Science, National Taiwan University
 
▍經歷
  • 2019-present  Associate Researcher, Department of Medical Research, National Taiwan University Hospital, Taiwan
  • 2013-2019    Assistant Researcher, Department of Medical Research, National Taiwan University Hospital, Taiwan
  • 2011-2013    Postdoctoral Research Fellow, Department of Immunology, Boston Children’s Hospital, Harvard Medical School, USA
  • 2008-2011    Postdoctoral Research Fellow, Institute of Molecular Biology, Academia Sinica, Taiwan

 

▍主要專長
  • Immunology
  • Flow Cytometry

 

▍研究方向
iNKT cells are a unique subset of T cells expressing an invariant TCRa chain. They bridge the gap between the innate and adaptive immune responses, and have been described in various immune responses and diseases, including tumor surveillance, defense against microbial infection, as well as pathogenesis of autoimmune diseases, graft-versus-host disease, obesity and asthma. Our studies are mainly focus on the development and effector functional differentiation of this rare but important cell population. We found the transcription factor Ets1 is essential for the early development of iNKT cells, whereas another transcription factor Gata3 is involved in the functional subset differentiation of iNKT cells. We also found a novel suppressive iNKT cell subset that developed during influenza infection early in life in mice and that suppressed the subsequent development of allergic asthma. We will further characterize this novel iNKTreg subset in human, and investigate its functionality in the regulation of GVHD after allogeneic HSCT.

 

▍近五年論文發表
  • Liao YY, Chuang YT, Lin HY, Lin NY, Hsu TW, Hsieh SC, Chen ST, Hung JS, Yang HJ, Liang JT, Huang MC, Huang J. GALNT2 promotes invasiveness of colorectal cancer cells partly through AXL. Mol Oncol. 2022 Nov 21. 13347. DOI: 10.1002/1878-0261.13347.
  • Chuang YT, Chuang WC, Liu CC, Liu CW, Huang YW, Yang HY, Ho IC, Tai TS. Ets1 Promotes the Differentiation of Post Selected iNKT Cells through Regulation of the Expression of Vα14Jα18 T Cell Receptor and PLZF. Int J Mol Sci. 2021 Nov 11;22(22):12199.
  • Tai TS, Tsao HW, Chuang WC, Liu CC, Huang YW, Oettgen P, Chuang YT, and Ho IC. Ets1 regulates the differentiation and function of iNKT cells through both Pointed domain dependent and independent mechanisms. Cellular and Molecular Immunology. 2020 Nov;17(11):1198-1200. DOI: 10.1038/s41423-020-0382-2. (Co-corresponding author) (IF=8.484, R/C= 15/159, Immunology)
  • Fang LW, Kao YH, Chuang YT, Huang HL, Tai TS. Ets-1 enhances tumor migration through regulation of CCR7 expression. BMB Rep. 2019 Sep;52(9):548-553. DOI: 10.5483/BMBRep.2019.52.9.232. (IF=3.167, R/C= 149/297, Biochemistry& Molecular Biology)
  • Chuang YT, Leung K, Chang YJ, DeKruyff RH, Savag PB, Cruse R, Benoit C, Elewaut D, Baumgarth N, Umetsu DT. A Natural Killer T cell subset that protects against airway hyperreactivity. J Allergy Clin Immunol., 2019 Feb;143(2):565-576. DOI: 10.1016/j.jaci.2018.03.022. (IF=14.11, R/C= 1/27, Allergy)
  • Chou TF, Chuang YT, Hsieh WC, Chang PY, Liu HY, Mo ST, Hsu TS, Miaw SC, Chen RH, Kimchi A, Lai MZ*.  Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression. Nat Commun. 2016 Jun, 7:11904. DOI: 10.1038/ncomms11904. (IF=12.124, R/C= 3/64, Multidisciplinary Sciences)