▍研究方向iNKT cells are a unique subset of T cells expressing an invariant TCRa chain. They bridge the gap between the innate and adaptive immune responses, and have been described in various immune responses and diseases, including tumor surveillance, defense against microbial infection, as well as pathogenesis of autoimmune diseases, graft-versus-host disease, obesity and asthma. Our studies are mainly focus on the development and effector functional differentiation of this rare but important cell population. We found the transcription factor Ets1 is essential for the early development of iNKT cells, whereas another transcription factor Gata3 is involved in the functional subset differentiation of iNKT cells. We also found a novel suppressive iNKT cell subset that developed during influenza infection early in life in mice and that suppressed the subsequent development of allergic asthma. We will further characterize this novel iNKTreg subset in human, and investigate its functionality in the regulation of GVHD after allogeneic HSCT.