▍經歷
- 國立臺灣大學醫學院(附設醫院)醫學研究部 助理研究員
- 國立臺灣大學醫學院 臨床醫學研究所 博士後研究員
▍主要專長
▍研究方向
- 疫苗及佐劑研發
- 抗病毒藥物研發
- 腫瘤治療
- 靈芝免疫調節之研究
- 天然抗氧化物之研究
▍近五年論文發表
- Chuang YT, Lin YL, Lin JY. Licochalcone A regulates viral IRES activity to inhibit enterovirus replication. Antiviral Research, 2024, Jan; 221:105755. DOI: 10.1016/j.antiviral.2023.105755
- Lin YL, Cheng PY, Chin CL, Chuang KT, Lin JY, Chang N, Pan CK, Lin CS, Pan SC, Chiang BL. A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge. Journal of Biomedical Science, 2023, Dec; 30(1):96. DOI: 10.1186/s12929-023-00987-3
- Chen JL, Pan CK, Lin LC, Tsai CY, Kuo CY, Huang YS, Lin YL*. Therapeutic efficacy of cyclin-dependent kinase inhibition in combination with ionizing radiation for lung cancer. International Journal of Radiation Biology, 2023, Aug; 99(8):1257-1266. DOI: 10.1080/09553002.2023.2161658
- Chen JL, Yang SJ, Pan CK, Lin LC, Tsai CY, Wang CH, Huang YS, Lin YL*, Kuo SH, Shieh MJ. (*Corresponding author) Cisplatin and albumin-based gold-cisplatin nanoparticles enhance ablative radiotherapy-induced antitumor immunity in local and distant tumor microenvironment. International Journal of Radiation Oncology Biology Physics, 2023, Aug; 116(5):1135-1149. DOI: 10.1016/j.ijrobp.2023.02.014
- Huang JH, Lin YL, Wang LC, Chiang BL. M2-like macrophages polarized by Foxp3− Treg-of-B cells ameliorate imiquimod-induced psoriasis. Journal of Cellular and Molecular Medicine, 2023, Jun; 27(11):1477-1492. DOI: 10.1111/jcmm.17748
- Chen JL, Pan CK, Lin YL*, Tsai CY, Huang YS, Yang WC, Hsu FM, Kuo SH, Shieh MJ. (*Corresponding author) Preclinical evaluation of PEGylated liposomal doxorubicin as an effective radiosensitizer in chemoradiotherapy for lung cancer. Strahlentherapie und Onkologie, 2021, Dec; 197(12):1131-1142. DOI: 10.1007/s00066-021-01835-9
- Chen JL, Pan CK, Huang YS, Tsai CY, Wang CW, Lin YL*, Kuo SH, Shieh MJ. (*Corresponding author) Evaluation of antitumor immunity by a combination treatment of high‑dose irradiation, anti‑PDL1, and anti‑angiogenic therapy in murine lung tumors. Cancer Immunology, Immunotherapy, 2021 Feb;70(2):391-404. DOI: 10.1007/s00262-020-02690-w
- Lin YL, Shih Chiaho, Cheng PY, Chin CL, Liou AT, Lee PY, Chiang BL. A Polysaccharide Purified From Ganoderma lucidum Acts as a Potent Mucosal Adjuvant That Promotes Protective Immunity Against the Lethal Challenge With Enterovirus A71. Frontiers in immunology, 2020, Sep; 29:11:561758. DOI: 10.3389/fimmu.2020.561758
- Chen JL, Shen CW, Wang CC, Huang YS, Chen JP, Chiang CH, Lin YL, Kuo SH, Wang CW. Impact of smoking cessation on clinical outcomes in patients with head and neck squamous cell carcinoma receiving curative chemoradiotherapy: A prospective study. Head Neck, 2019, Sep; 41(9):3201-3210. DOI: 10.1002/hed.25814
- Chen JL, Chang CC, Huang YS, Kuo HY, Chen TY, Wang CW, Kuo SH, Lin YL*. Persistently elevated soluble MHC class I polypeptide-related sequence A and transforming growth factor-β1 levels are poor prognostic factors in head and neck squamous cell carcinoma after definitive chemoradiotherapy. PLoS One, 2018, Aug; 13(8):e0202224. DOI: 10.1371/journal.pone.0202224
- Jan RH, Chen CJ, Hong YR, Lin YL*, Chen LK*. A surface antigen of Orientia tsutsugamushi activates human monocyte-derived dendritic cells via nuclear factor-kB & p38 mitogen-activated protein kinase pathways. Indian Journal of Medical Research, 2018, Aug; 148(2): 215-224. DOI: 10.4103/ijmr.IJMR_1417_16
- Lin YL, Cheng PY, Chin CL, Huang LM, Lin SY, Chiang BL. Fibroblast-stimulating lipopeptide-1 as a potential mucosal adjuvant enhances mucosal and systemic immune responses to enterovirus 71 vaccine. Vaccine, 2018, Jul; 36(29):4331-4338. DOI: 10.1016/j.vaccine.2018.05.090
- Lin YL, Chow YH, Huang LM, Hsieh SM, Cheng PY, Hu KC, Chiang BL. A CpG-adjuvanted intranasal enterovirus 71 vaccine elicits mucosal and systemic immune responses and protects human SCARB2-transgenic mice against lethal challenge. Scientific Reports, 2018, Jul; 8(1):10713. DOI: 10.1038/s41598-018-28281-5
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